Physiologically based pharmacokinetic models for trichloroethylene and its oxidative metabolites

Environmental Health Perspectives

Volumn 108, Issue SUPPL. 2, 2000, Pages 265-273

  Fisher, Jeffrey W ^a  

^a AIR FORCE RESEARCH LABORATORY   (United States)

Author keywords

Chloral hydrate; Dichloroacetic acid; Human; Metabolism; PBPK models; Pharmacokinetics; Rodents; Trichloroacetic acid; Trichloroethanol; Trichloroethylene

Indexed keywords

CYTOCHROME P450; TRICHLOROACETIC ACID; TRICHLOROETHYLENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; BLOOD LEVEL; BODY WEIGHT; COMPARTMENT MODEL; CONTROLLED STUDY; FEMALE; HEART OUTPUT; HUMAN; LIVER CARCINOGENESIS; LUNG VENTILATION; MALE; MEDICAL DECISION MAKING; METABOLISM; METABOLITE; MOUSE; MOUSE STRAIN; NONHUMAN; PARTITION COEFFICIENT; PHYSIOLOGY; PRIORITY JOURNAL; TOXICOKINETICS;

ANIMALIA; MARTES PENNANTI; RODENTIA;

EID: 0033934377     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.00108s2265     Document Type: Article

References (38)

1. Sato A, Nakajima T, Fujiwara Y, Murayama N. A pharmacokinetic model to study the excretion of trichloroethylene and its metabolites after an inhalation exposure. Br J Ind Health 34:56-63 (1977).
2. Fernandez JG, Droz PO, Humbert BE, Caperous JR. Trichloroethylene exposure: simulation of uptake, excretion, and metabolism using a mathematical model. Br J Ind Med 34:43-55 (1977).
3. Andersen ME, Gargas ML, Clewill HJ III, Severyn KM. Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,2-dichloroethylene in vivo using gas uptake methods. Toxicol Appl Pharmacol 89:149-157 (1987).
4. Dallas CE, Gallo JM, Hamanathan R, Muralidhara S, Bruckner J. Physiological pharmacokinetic modeling of inhaled trichlorethylene in rats. Toxicol Appl Pharmacol 110:303-314 (1991).
5. Bogen KT. Pharmacokinetics for regulatory analysis: the case of trichloroethylene. Regul Toxicol Pharmacol 6:447-466 (1988).
6. U.S. EPA. Health Assessment Document for Trichloroethylene. EPA 600/8-82-/006F. PB-249696. Washington, DC:U.S. Environmental Protection Agency, 1985.
7. Koizumi A. Potential of physiologically based pharmacokinetics to amalgamate kinetic data of trichloroethylene and tetrachloroethylene obtained in rats and man. Br J Ind Med 46:239-249 (1989).
8. Fisher JW, Whittaker TA, Taylor DH, Clewell HJ III, Andersen ME. Physiologically based pharmacokinetic modeling of the pregnant rat: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid. Toxicol Appl Pharmacol 99:396-414 (1989).
9. Fisher JW, Whittaker TA, Taylor OH, Clewell HJ III, Andersen ME. Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid. Toxicol Appl Pharmacol 102:497-515 (1990).
10. Herren-Freund, SL, Pereira, MA, Khoury, MD, Olson, G. The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver Toxicol Appl Pharmacol 90:183-189 (1987).
11. Fisher JW, Gargas ML, Allen BC, Andersen ME. Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolites, trichloroacetic acid, in the rat and mouse. Toxicol Appl Pharmacol 109:183-195 (1991).
12. Fisher JW, Allen BC. Evaluating the risk of liver cancer in humans exposed to trichloroethylene using physiological models. Risk Anal 13:87-95 (1993).
13. Allen BC, Fisher JW. Pharmacokinetic modeling of trichloroethylene and trichloroacetic acid in humans. Risk Anal 13:71-86 (1993).
14. Abbas R, Fisher JW. A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, trichloroethanol glucuronide in B6C3F1 mice. Toxicol Appl Pharmacol 147:15-30 (1997).
15. Greenberg, MS, Burton, Jr. GA, and Fisher JW. Physiologically based pharmacokinetic modeling of inhaled trichloroethylene and its oxidative metabolites in B6C3F1 mice. Toxicol Appl Pharmacol 154:264-278 (1999).
16. Fisher JW, Mahle DA, Abbas R. A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol. Toxicol Appl Pharmacol 152:339-359 (1998).
17. Cronin WC IV, Oswald EJ, Shelley ML, Fisher JW, Flemming CD. A trichloroethylene risk assessment using a Monte Carlo analysis of parameter uncertainty in conjunction with physiologically-based pharmacokinetic modeling. Risk Anal 15:555-565 (1995).
18. Clewell HJ, Gentry PR, Gearhart JM, Allen BC, Andersen ME. Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: examples with vinyl chloride and trichloroethylene. Chemosphere 31:2561-2578 (1995).
19. Bogen KT, Gold LS. Trichloroethylene cancer risk: simplified calculation of PBPK-based MCLs for cytotoxic endpoints. Regul Toxicol Pharmacol 25:26-42 (1997).
20. Simon T. Combining physiologically based pharmacokinetic modeling with Monte Carlo simulation to derive an acute inhalation guidance value for trichloroethylene. Regul Toxicol Pharmacol 26:257-270 (1997).
21. Ramsey JC, Andersen ME. A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol Appl Pharmacol 73:159-175 (1984).
22. U.S. EPA. Addendum to the Health Assessment Document for Trichloroethylene: Updated Carcinogencity Assessment for Trichloroethylene. Draft. EPA/600/8-82/006FA. Washington, DC:U.S. Environmental Protection Agency, 1987.
23. Davidson IWF, Beliles RP. Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics Drug Metab Rev 23(5&6):493-599 (1991).
24. Larson JL, Bull RJ. Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice. Toxicol App Pharmacol 115:268-277 (1992).
25. Gearhart JM, Mahle DA, Greene RJ, Seckel CS, Flemming CD, Fisher JW, Clewell HA III. Variability of physiologically based pharmacokinetic (PB-PK) model parameters and their effects on PB-PK model predictions in a risk assessment for perchloroethylene (PCE). Toxicol Lett 68:131-144 (1993).
26. Jepson GW, Hoover DK, Black RK, McCafferty JO, Mahle DA, Gearhart JM. A partition coefficient method for non-volatile and intermediate volatility chemicals in biological tissues. Fundam Appl Toxicol 22:519-524 (1994).
27. Abbas R, Seckel CS, MacMahon KL, Fisher JW. Determination of kinetic rate constants for chloral hydrate, trichloroethanol, trichloroacetic acid, and dichloroacetic acid - a physiologically based modeling approach. Toxicologist 36:32 (1997).
28. Abbas R, Seckel CS, MacMahon KL, Kidney JK, Fisher JW. Pharmacokinetic analysis of chloral hydrate and its metabolism in B6C3F1 mice. Drug Metab Dispos 24:1340-1346 (1996).
29. Fisher JW. Erratum (1997) to Abbas et al. Drug Metab Dispos 25(12):1449 (1996).
30. Johanson G. Modeling of respiratory exchange of polar solvents. Ann Occup Hyg 35:323-339 (1991).
31. Marshall EK, Owens AH Jr. Absorption excretion, and metabolic fate of chloral hydrate and trichloroethanol. Bull Johns Hopkins Hosp 95:1-18 (1954).
32. Paykoc ZV, Powell JF. The excretion of sodium trichloroacetate. J Pharmacol Exp Ther 85:289-293 (1945).
33. Raymer JH, Kizakevich ML, McCartney ML, Pellizzari ED. Facilities for human exposure studies. Environ Sci Technol 27:1733-1735 (1993).
34. Pleil JD, Lindstrom AB. Collection of a single alveolar breath for volatile compounds analysis. Am J Ind Med 28:109-121 (1995).
35. Ketcha MM, Warren DA, Bishop CT, Brashear WT. Factors influencing the conversion of trichloroacetic acid to dichloroacetic acid in biological matrices. J Anal Toxicol 20:236-241 (1996).
36. Erratum (1995) to Templin et al. Toxicol Appl Pharmacol 133:177 (1993).
37. Beland FA, Schmitt TC, Fullerton NF, Young JF. Metabolism of chloral hydrate in mice and rats after single and multiple doses. J Toxicol Environ Health 54:209-226 (1998).
38. Muralidhara S, Bruckner JV. Simple method for rapid measurement of trichloroethylene and its major metabolites in biological samples. J Chromatog B 732:145-153 (1999).