Dichloroacetate and trichloroacetate promote clonal expansion of anchorage-independent hepatocytes in vivo and in vitro

Toxicology and Applied Pharmacology

Volumn 150, Issue 2, 1998, Pages 287-294

  Stauber, A J ^a   Bull, R J ^a,b   Thrall, B D ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

Anchorage independence; c Fos; c Jun; Dichloroacetate (DCA); Hepatocarcinogenesis; Tichloroacetate (TCA); Tumor promoter

Indexed keywords

DICHLOROACETIC ACID; TRICHLOROACETIC ACID;

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DRUG COMPARISON; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CULTURE; MOUSE; NONHUMAN; ONCOGENE C JUN; PHENOTYPE; TECHNIQUE;

ANIMALIA;

EID: 0032103380     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8417     Document Type: Article

References (39)

1. Anderson M. E., Mills J. J., Jirtle R. L., Greenlee W. F. Negative selection in hepatic tumor promotion in relation to cancer risk assessment. Toxicology. 102:1995;223-237.
2. Barrett J. C. Mechanisms of multistep carcinogenesis and carcinogen risk assessment. Environ. Health Perspect. 100:1993;9-20.
3. Bull R. J., Sanchez I. M., Nelson M. A., Larson J. L., Lansing A. J. Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate. Toxicology. 63:1990;341-359.
4. Carter J. H., Carter H. W., DeAngelo A. B. Biochemical, pathologic and morphometric alterations induced in male B6C3F1 mouse liver by short-term exposure to dichloroacetic acid. Toxicol. Lett. 81:1995;55-71.
5. Chang L. W., Daniel F. B., DeAngelo A. B. Analysis of DNA strand breaks induced in rodent liverin vivo, Environ. Mol. Mutagen. 20:1992;277-288.
6. Chiao C., Zhang Y., Kaufman D. G., Kaufmann W. K. Derivation of phenobarbital-responsive immortal rat hepatocytes. Am. J. Pathol. 146:1995;1248-1259.
7. Colburn N. H., Bruegge W. F. V., Bates J. R., Gray R. H., Rossen J. D., Kelsey W. H., Shimada T. Correlation of anchorage-independent growth with tumorigenicity of chemically transformed mouse epidermal cells. Cancer Res. 38:1978;624-634.
8. Colburn N. H., Former B. F., Nelson K. A., Yuspa S. H. Tumour promoter induces anchorage independence irreversibly. Nature. 281:1979;589-591.
9. Daniel F. B., DeAngelo A. B., Stober J. A., Olson G. R., Page N. P. Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse. Fundam. Appl. Toxicol. 19:1992;159-168.
10. DeAngelo A., Daniel F. B., Most B. M., Olson G. R. The carcinogenicity of dichloroacetic acid in the male Fischer 344 rat. Toxicology. 114:1996;207-221.
11. DeAngelo A. B., Daniel F. B., Stober J. A., Olson G. R. The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse. Fundam. Appl. Toxicol. 16:1991;337-347.
12. DeMarini D. M., Perry E., Shelton M. L. Dichloroacetic acid and related compounds: Induction of prophageE. coliSalmonella. Mutagenesis. 9:1994;429-437.
13. Dong Z., Cmarik J. L., Wendel E. J., Colburn N. H. Differential transformation efficiency but not AP-1 induction under anchorage-dependent and -independent conditions. Carcinogenesis. 15:1994;1001-1004.
14. Fox A. W., Yang X., Murli H., Lawlor T. E., Cifone M. A., Frederick R. E. Absence of mutagenic effects of sodium dichloroacetate. Fundam. Appl. Toxicol. 32:1996;87-95.
15. Fuscoe J. S., Afshari A. J., George M. H., DeAngelo A. B., Tice R. R., Salman T., Allen J. W. In vivo genotoxicity of dichloroacetic acid: Evaluation with the mouse peripheral blood micronucleus assay and the single cell gel assay. Environ. Mol. Mutagen. 27:1996;1-9.
16. Haseman J. K., Huff J. E., Boorman G. A. Use of historical control data in carcinogenic studies in rodents. Toxicol. Pathol. 12:1984;126-135.
17. Herren-Freund S. L., Pereira M. A., Khoury M. D., Olson G. The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. Toxicol. Appl. Pharmacol. 90:1987;183-189.
18. James N. H., Roberts R. A. The peroxisome proliferator class of non-genotoxic hepatocarcinogens synergize with epidermal growth factor to promote clonal expansion of initiated rat hepatocytes. Carcinogenesis. 15:1994;2687-2694.
19. Kato-Weinstein, J. Lingohr, M. K. Thrall, B. D. Bull, R. J. 1998, Effects of dichloroacetate on carbohydrate metabolism in B6C3F1 mice.
20. Nakano H., Hatayama I., Satoh K., Suzuki S., Sato K., Tsuchida S. c-Jun expression in single cells and preneoplastic foci induced by diethylnitrosamine in B6C3F1 mice: Comparison with the expression of the pi-class glutathioneS. Carcinogenesis. 15:1994;1853-1857.
21. Nelson M. A., Bull R. J. Induction of strand breaks in DNA by trichloroethylene and metabolites in rat and mouse liver in vivo. Toxicol. Appl. Pharmacol. 94:1988;45-54.
22. Nestmann E. R., Chu I., Kowbel D. J., Matala T. I. Short lived mutagen inSalmonella. Can. J. Genet. Cytol. 22:1980;35-40.
23. Nettesheim P., Fitzgerald D. J., Kitamura H., Walker C. L., Gilmer T. M., Barrett J. C., Gray T. E. In vitro. Environ. Health Perspect. 75:1987;71-79.
24. Parrish J. M., Austin E. W., Stevens D. K., Kinder D. H., Bull R. J. Haloacetate-induced oxidative damage to DNA in the liver of B6C3F1 mice. Toxicology. 110:1996;103-111.
25. Pereira M. A. Carcinogenic activity of dichloroacetic acid and trichloroacetic acid in the liver of female B6C3F1 mice. Fundam. Appl. Toxicol. 31:1996;192-199.
26. Pereira M. A., Li K., Kramer P. M. Promotion by mixtures of dichloroacetic acid and trichloroacetic acid ofNN. Cancer Lett. 115:1997;15-23.
27. Pereira M. A., Phelps J. B. Promotion by dichloroacetic acid and trichloroacetic acid ofNN. Cancer Lett. 102:1996;133-141.
28. Rapson W. H., Nazar M. A., Butsky V. V. Mutagenicity produced by aqueous chlorination of organic compounds. Bull. Environ. Contam. Toxicol. 24:1980;590-597.
29. Richmond R. E., Carter J. H., Carter H. W., Daniel F. B., DeAngelo A. B. Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F344) rats. Cancer Lett. 92:1995;67-76.
30. Richmond R. E., DeAngelo A. B., Potter C. L., Daniel F. B. The role of hyperplastic nodules in dichloroacetic acid-induced hepatocarcinogenesis in B6C3F1 male mice. Carcinogenesis. 12:1991;1383-1387.
31. Schulte-Hermann R., Bursch W., Kraupp-Grasl B., Oberhammer F., Wagner A., Jirtle R. Cell proliferation and apoptosis in normal liver and preneoplastic foci. Environ. Health Perspect. 101:1993;87-90.
32. Singer P. C., Chang S. D. Correlations between trihalomethanes and total organic halides formed during water treatment. J. AWWA. 81:1989;61-65.
33. Snyder R. D., Pullman J., Carter J. H., Carter H. W., DeAngelo A. B. In vivo administration of dichloroacetic acid suppresses spontaneous apoptosis in murine hepatocytes. Cancer Res. 55:1995;3702-3705.
34. Stauber A. J., Bull R. J. Differences in phenotype and cell replicative behavior of hepatic tumors induced by dichloroacetate (DCA) and trichloroacetate (TCA). Toxicol. Appl. Pharmacol. 144:1997;235-246.
35. Styles J. A., Wyatt I., Coutts C. Trichloroacetic acid: Studies on uptake and effects on hepatic DNA and liver growth in mouse. Carcinogenesis. 12:1991;1715-1719.
36. Uden P. C., Miller J. W. Chlorinated acids and chloral in drinking water. J. AWWA. 12:1983;1715-1719.
37. Waskell L. A study of the mutagenicity of anesthetics and their metabolites. Mutat. Res. 57:1978;141-153.
38. Waxman D. J., Morrissey J. J., Naik S., Jauregui H. O. Phenobarbital induction of cytochromesP. Biochem J. 271:1990;113-119.
39. Xia Z., Dickens M., Raingeaud J., Davis R. J., Greenberg M. E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (Washington, D.C.). 270:1995;1326-1331.