Targeted replacement of rodent CCR2 with the human orthologue CCR2B: A mouse model for in vivo analysis of human target-selective small molecule MCP-1 receptor antagonists

Drug Development Research

Volumn 55, Issue 4, 2002, Pages 197-209

  Prosser, Haydn M ^a   Cooper, David G ^a   Forbes, Ian T ^a   Geppert, Martin ^a   Gribble, Andrew D ^a   Grau, Evelyn V ^a   Groot, Pieter H ^a   Harper, Alex J ^a   Moores, Kitty E ^a   Pickering, Susan J ^a   Piercy, Valerie ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Chemokine; Chemotaxis; Homologous recombination; Thioglycollate

Indexed keywords

CHEMOKINE RECEPOTR CCR2B BLOCKING AGENT; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2B; MONOCYTE CHEMOTACTIC PROTEIN 1; RECEPTOR BLOCKING AGENT; SB 399721; THIOGLYCOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE TECHNOLOGY; GENETIC ENGINEERING; HOMOZYGOSITY; HUMAN; HUMAN CELL; KNOCKIN MOUSE; MACROPHAGE; MALE; MONOCYTE; MOUSE; MOUSE MUTANT; MOUSE STRAIN; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RODENT;

EID: 0036068141     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10044     Document Type: Article

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