Interaction with simian Hck tyrosine kinase reveals convergent evolution of the Nef protein from simian and human immunodeficiency viruses despite differential molecular surface usage

Virology

Volumn 295, Issue 2, 2002, Pages 320-327

  Picard, C ^a   Greenway, A ^b   Holloway, G ^b   Olive, D ^a   Collette, Y ^a  

^a INSERM   (France)

^b MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HEMATOPOIETIC CELL KINASE; NEF PROTEIN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CONTROLLED STUDY; ENZYME ANALYSIS; HUMAN IMMUNODEFICIENCY VIRUS; LENTIVIRINAE; MOLECULAR CLONING; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIMIAN IMMUNODEFICIENCY VIRUS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIMATES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0036063651     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2002.1381     Document Type: Article

References (48)

1. The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling
2. RT loop flexibility enhances the specificity of src family SH3 domains for HIV-1 Nef
3. Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation
4. A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
5. SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1
6. Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques
7. HIV-2 and SIV nef proteins target different Src family SH3 domains than does HIV-1 Nef because of a triple amino acid substitution
8. Specific Th1 cytokine down-regulation associated with primary clinically derived human immunodeficiency virus type 1 nef gene-induced expression
9. Physical and functional interaction of nef with lck-HIV-1 nef-induced T-cell signaling defects
10. Interaction of HIV-1 nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
11. Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys
12. The human immunodeficiency virus type 1 NEF protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism
13. The HIV Nef protein alters Ca(2+) signaling in myelomonocytic cells through SH3-mediated protein-protein interactions
14. A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
15. The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
16. Human immunodefi-ciency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines
17. Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen protein kinase, inhibiting kinase activity
18. Simian immunodeficiency virus and human immunodeficiency virus type 1 Nef proteins show distinct patterns and mechanisms of Src kinase activation
19. Protein modelling for all
20. Induction of fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj14
21. Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2
22. Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling
23. Role of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaques
24. Src kinase-mediated signaling in leukocytes
25. Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques
26. A single amino acid in the sh3 domain of hck determines its high affinity and specificity in binding to HIV-1 nef protein
27. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
28. Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus
29. Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA
30. Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking
31. Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway
32. The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
33. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement
34. Nef-An adaptor adaptor?
35. The down-regulation of CD4 and MHC-I by primate lentiviruses: A paradigm for the modulation of cell surface receptors
36. Interactions of HIV-1 NEF with cellular signal transducing proteins
37. Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef3 viruses but not for down-regulation of CD4
38. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
39. HIV-1 Nef increases T cell activation in a stimulus-dependent manner
40. Crystal structure of the Src family tyrosine kinase Hck
41. The nef gene products of both simian and human immunodeficiency viruses enhance virus infectivity and are functionally interchangeable
42. HIV and SIV Nef modulate signal transduction and protein sorting in T cells
43. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes
44. Simian and human immunodeficiency virus nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression
45. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages
46. The Nef protein of HIV-1 associates with rafts and primes T cells for activation
47. HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis
48. Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway