New pharmacological strategies for pain relief

Expert Review of Neurotherapeutics

Volumn 2, Issue 5, 2002, Pages 691-702

  Gillen, Clemens ^a   Maul, Corinna ^a  

^a GRÜNENTHAL GMBH   (Germany)

Author keywords

Analgesics; Antisense; Cannabinoids; Capsaicin; Gabapentin; Gene therapy; NMDA; NSAID; Opioid; Pain

Indexed keywords

ADL 100101; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CANNABINOID; CAPSAICIN DERIVATIVE; CAPSAVANIL; CIZOLIRTINE; CLONIDINE; CNS 5161; DEXTROMETHORPHAN; ELIPRODIL; FADOLMIDINE; GABAPENTIN; IFENPRODIL; KAPPA OPIATE RECEPTOR AGONIST; KETAMINE; MU OPIATE RECEPTOR AGONIST; N (4 AMINO 2 METHYL 6 QUINOLINYL) 2 (4 ETHYLPHENOXYMETHYL)BENZAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NABILONE; NAPROXEN; NITRONAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; OPIATE ANTAGONIST; PREGABALIN; PROPIRAM; RESINIFERATOXIN; RETIGABINE; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANALGESIA; CARDIOVASCULAR DISEASE; CHRONIC PAIN; CLINICAL TRIAL; DIGESTIVE SYSTEM ULCER; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG MECHANISM; DRUG SAFETY; DRUG TARGETING; HUMAN; MEDICAL RESEARCH; MOLECULAR BIOLOGY; REVIEW;

EID: 0036042670     PISSN: 14737175     EISSN: None     Source Type: Journal    
DOI: 10.1586/14737175.2.5.691     Document Type: Review

References (67)

1. A tetrodotoxin-resistant sodium channel expressed by C-fibre associated sensory neurons
2. A P2X purinoceptor expressed by a subset of sensory neurons
3. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs
4. Identification and characterization of two G-protein coupled receptors for neuropeptide FF
5. Receptor for the pain modulatory neuropeptides FF and AF is an orphan G-protein coupled receptor
6. Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors
7. The capsaicin-recepton a heat-activated ion channel in the pain-pathway
8. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids
9. Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV 1.8
10. Antisense oligonucleotide treatment to the brain cannabinoid receptor inhibits antinociception
11. Neuronal plasticity: Increasing the gain in pain
12. Na by PKC and and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro
13. Activation of silent mechanoceptive cat C and A sensory neurons and their substance P expression following peripheral inflammation
14. Neuronal plasticity and signal transduction in nociceptive neurons: Implications for the initiation and maintenance of pathological pain
15. Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord
16. Pain mechanisms: A new theory
17. Descending control of pain
18. ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization
19. Isolation and structure of the endogenous agonist of the opioid receptor-like ORL 1 receptor
20. Orphanin FQ. A neuropeptide that activates an opioid like G-protein coupled receptor
21. The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics
22. 4-Aminoquinolines: Novel nociceptin antagonists with analgesic activity
23. Peripheral analgesic actions of opioids
24. Peripheral opioid analgesia: Mechanisms and clinical implications
25. Effect of kappa agonists on visceral nociception induced by uterine cervical distension in rats
26. Propiram shire
27. μ-selektive opioide ohne morphinanstruktur
28. The function of noradrenergic neurons in mediating antinociception induced by electrical stimulation of the locus coeruleus in two different sources of Sprague-Dawley rats
29. Neuroanatomy of the pain system and of the pathways that modulate pain
30. Epidural adrenaline and clonidine: Segmental analgesia and effects on different pain modalities
31. The mechanical antihyperalgesic effect of intrathecally administered MPV-2426, a novel alpha2-adrenoceptor agonist, in a rat model of postoperative pain
32. Adenosine receptors: Targets for future drugs
33. Roles of purines in nociception and pain
34. Cellular and molecular mechanisms underlying learning and memory impairments produced by cannabinoids
35. Gabapentin in pain management
36. Evidence for the use of gabapentin in the treatment of diabetic peripheral neuropathy
37. Gabapentin in postherpetic neuralgia: A randomised, double-blind, placebo-controlled study
38. Differential effect of gabapentin on neumal and muscle calcium currents
39. Pregabalin
40. Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine
41. The novel anticonvulsant retigabine activates M-current in Chinese hamster ovary-cells transfected with human KCNQ2/3 subunits
42. Retigabine, a novel anticonvulsant, enhances activation of KCNQ2/Q 3 potassium channels
43. Activation of expressed KCNQ potassium currents and native neuronal Mtype potassium currents by the anticonvulsant drug retigabine
44. KCNQ potassium channels: Physiology, pathophysiology and pharmacology
45. Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes
46. Cloning and functional expression of a human orthologue of rat vanilloid receptor-1
47. Mechanisms and therapeutic potential of vanilloids (capsaicin-like molecules)
48. Capsaicin and pain mechanisms
49. Capsazepine shows species selective antihyperalgesic effects in models of chronic inflammatory and neuropathic pain
50. Molecular mechanisms of nociception
51. Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor
52. Transmission of chronic nociception by spinal neurons expressing the substance P receptor
53. Design of antisense oligonucleotides stabilized by locked nudeic acids
54. CGRP binding Spiegelmers: A new therapeutic approach for migraine
55. Nociceptin/Orphanin FQ binding Spiegelmers (L-RNA): A new pharmacological tool for studying nociceptin effects
56. A paracrine paradigm for in vivo gene therapy in the central nervous system: Treatment of chronic pain
57. Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus
58. Therapeutic efficacy in experimental polyarthritis of viral-driven enkephalin overproduction in sensory neurons
59. Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion
60. Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients
61. Towards pain treatment based on the classification of pain-generating mechanisms?
62. Mechanism-based pain diagnosis
63. Tramadol/acetaminophen combination tablets for the reatment of osteoarthritis flare pain: A multicenter, out-patient, randomized, double-blind, placebo-controlled, parallel-group, add-on study