Protein kinase C-ζ overexpression induces erythroid phenotype in the monocytic leukaemia cell line U937

British Journal of Haematology

Volumn 118, Issue 2, 2002, Pages 646-653

  Mansat De Mas, Véronique ^a,b,d   De Thonel, Aurélie ^a   Gaulin, Vanessa ^a   Demur, Cécile ^a,b   Laurent, Guy ^a,c   Quillet Mary, Anne ^a  

^a INSERM   (France)

^b Laboratoire d'Hematologie   (France)

^c CHU PURPAN   (France)

^d INSTITUT CLAUDIUS REGAUD   (France)

Author keywords

ERK 1; Erythroid phenotype; GATA 1; PKC ; U937 cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; GLYCOPHORIN A; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE C ZETA; TRANSCRIPTION FACTOR GATA 1;

ARTICLE; CELL STRAIN U937; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ERYTHROCYTE; GENE CONTROL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LEUKEMIA CELL LINE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

CELL DIFFERENTIATION; DNA-BINDING PROTEINS; ERYTHROID PROGENITOR CELLS; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; FLOW CYTOMETRY; GATA1 TRANSCRIPTION FACTOR; HUMANS; LEUKEMIA; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; PHOSPHORYLATION; PROTEIN KINASE C; TRANSCRIPTION FACTORS; U937 CELLS;

EID: 0036036872     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03625.x     Document Type: Article

References (41)

1. Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21 (ras) and protein kinaseC zeta in primary endothelial cells
2. Lineage-restricted expression of protein kinase C isoforms in hematopoiesis
3. Regulation of caspase activation and cis-diamminedichloroplatinium (II) -induced cell death by protein kinase C
4. Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents
5. Evidence for a role of MEK and MAPK during signal transduction by protein kinase C ζ
6. Accumulation of catalytically active PKC-ζ into the nucleus of the HL-60 myeloid cell line plays a key role in the induction of granulocytic differentiation mediated by all-trans retinoic acid
7. Phosphatidylinositol-3-kinase activation and atypical protein kinase C zeta phosphorylation characterize the DMSO signalling in erythroleukemia cells
8. Phosphorylation of the erythroid transcription factor GATA-1
9. Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes
10. The product of Par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
11. Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta
12. Role of PU.1 in hematopoiesis
13. GATA-1 and FOG-dependent activation of megakaryocytic alpha IIB gene expression
14. Inhibition of atypical PKC blocks ultraviolet-induced AP-1 activation by specifically inhibiting ERKs activation
15. Involvement of LDL receptor in the proliferation of vascular smooth muscle cells
16. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation
17. PhosphoBase, a database of phosphorylation sites: Release 2.0
18. Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes
19. Selective modulation of specific protein kinase C (PKC) isoforms in primary human megakaryocytic vs. erythroid cells
20. Nuclear mitogen-activated protein kinase activation by protein kinase C zeta during reoxygenation after ischemic hypoxia
21. ζ Protein kinase C: A new target for antiproliferative interactions
22. The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters
23. PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid
24. Protein kinase C-α isoform is involved in erythropoietin-induced erythroid differentiation of CD34+ progenitor cells from bone marrow
25. Increase in nuclear phosphatidylinositol 3-kinase activity and phosphatidylinositol (3,4,5) triphosphate synthesis preced PKC-ζ translocation to the nucleus of NGF-treated PC12 cells
26. PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors
27. GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription
28. Differential expression of protein kinase C isoform transcripts in human hematopoietic progenitors undergoing differentiation
29. Phosphorylation of GATA-1 increases its DNA-binding affinity and is correlated with induction of human K562 erythroleukaemia cells
30. WT1 and GATA-1 expression in myelodysplastic syndrome and acute leukemia
31. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development
32. The Ets-related transcription factor PU.1 immortalizes erythroblasts
33. Protein kinases as mediators of phosphoinositide 3-kinase signalling
34. Overexpression of protein kinase C-ζ stimulates leukemic differentiation
35. GATA transcription factors: Key regulators of hematopoiesis
36. Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase
37. Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways
38. Overexpressing of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-κB dependent pathway
39. Forced GATA-1 expression in the murine myeloid cell line M1: Induction of c-mpl expression and megakaryocytic/erythroid differentiation
40. PMA-induced megakaryocytic differentiation of HEL cells is accompanied by striking modifications of protein kinase C catalytic activity and isoform composition at the nuclear level
41. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding