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Volumn 60, Issue 12, 2000, Pages 3262-3270

Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CYTOSINE DERIVATIVE; DNA; DNA METHYLTRANSFERASE; MESSENGER RNA; METHYLNITROSOUREA;

EID: 0034046394     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (81)

References (41)
  • 1
    • 0025195404 scopus 로고
    • 6-alkylguanine-DNA alkyltransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents
    • 6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res., 50: 6119-6129, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 6119-6129
    • Pegg, A.E.1
  • 2
    • 0026750738 scopus 로고
    • Self-destruction and tolerance in resistance of mammalian cells to alkylation damage
    • Karran, P., and Bignami, M. Self-destruction and tolerance in resistance of mammalian cells to alkylation damage. Nucleic Acids Res., 20: 2933-2940, 1992.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 2933-2940
    • Karran, P.1    Bignami, M.2
  • 3
    • 0021020105 scopus 로고
    • 6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase in human organs
    • Lond.
    • 6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase in human organs. Carcinogenesis (Lond.), 4: 1565-1568, 1983.
    • (1983) Carcinogenesis , vol.4 , pp. 1565-1568
    • Myrnes, B.1    Giercksky, K.E.2    Krokan, H.3
  • 4
    • 0021894988 scopus 로고
    • 6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis
    • 6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis. Mutat. Res., 145: 1-16, 1985.
    • (1985) Mutat. Res. , vol.145 , pp. 1-16
    • Yarosh, D.B.1
  • 8
    • 0029068041 scopus 로고
    • 6-methylguanine-DNA methyltransferase promoter: Correlaton with gene suppression
    • Lond.
    • 6-methylguanine-DNA methyltransferase promoter: correlaton with gene suppression. Carcinogenesis (Lond.), 16: 1385-1390, 1995.
    • (1995) Carcinogenesis , vol.16 , pp. 1385-1390
    • Qian, X.1    Von Wronski, M.A.2    Brent, T.P.3
  • 9
    • 0032960181 scopus 로고    scopus 로고
    • Cancer epigenetics comes of age
    • Jones, P. A., and Laird, P. W. Cancer epigenetics comes of age. Nat. Genet., 21: 163-167, 1999.
    • (1999) Nat. Genet. , vol.21 , pp. 163-167
    • Jones, P.A.1    Laird, P.W.2
  • 10
  • 12
    • 0030823671 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase gene
    • 6-methylguanine-DNA methyltransferase gene. Cancer Res., 57: 3672-3677, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 3672-3677
    • Qian, X.C.1    Brent, T.P.2
  • 13
  • 14
    • 0032894125 scopus 로고    scopus 로고
    • Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients
    • Esteller, M., Sanchez-Cespedes, M., Rosell, R., Sidransky, D., Baylin, S. B., and Herman, J. G. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res., 59: 67-70, 1999.
    • (1999) Cancer Res. , vol.59 , pp. 67-70
    • Esteller, M.1    Sanchez-Cespedes, M.2    Rosell, R.3    Sidransky, D.4    Baylin, S.B.5    Herman, J.G.6
  • 15
    • 0030457071 scopus 로고    scopus 로고
    • Genomic instability and tolerance to alkylating agents
    • Karran, P., and Hampson, R. Genomic instability and tolerance to alkylating agents. Cancer Surv. 28: 69-85, 1996.
    • (1996) Cancer Surv. , vol.28 , pp. 69-85
    • Karran, P.1    Hampson, R.2
  • 17
    • 0028941627 scopus 로고
    • Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs
    • Li, G-M., and Modrich, P. Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. Proc. Natl. Acad. Sci. USA, 92: 1950-1954, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1950-1954
    • Li, G.-M.1    Modrich, P.2
  • 18
    • 0030667839 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells
    • 6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells. J. Biol. Chem., 272: 28596-28606, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28596-28606
    • Hampson, R.1    Humbert, O.2    Macpherson, P.3    Aquilina, G.4    Karran, P.5
  • 19
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • Kane, M. F., Loda, M., Gaida, G. M., Lipman, J., Mishra, R., Goldman, H., Jessup, J. M., and Kolodner, R. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res., 57: 808-811, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3    Lipman, J.4    Mishra, R.5    Goldman, H.6    Jessup, J.M.7    Kolodner, R.8
  • 20
    • 0032487831 scopus 로고    scopus 로고
    • MLHI promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas
    • Esteller, M., Levine, R., Baylin, S. B., Ellenson, L. H., and Herman, J. G. MLHI promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. Oncogene, 16: 2413-2417, 1998.
    • (1998) Oncogene , vol.16 , pp. 2413-2417
    • Esteller, M.1    Levine, R.2    Baylin, S.B.3    Ellenson, L.H.4    Herman, J.G.5
  • 21
    • 0033535612 scopus 로고    scopus 로고
    • A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer
    • Strathdee, G., MacKean, M. J., Illand, M., and Brown, R. A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer. Oncogene, 18: 2335-2341, 1999.
    • (1999) Oncogene , vol.18 , pp. 2335-2341
    • Strathdee, G.1    MacKean, M.J.2    Illand, M.3    Brown, R.4
  • 22
    • 0029007870 scopus 로고
    • DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines
    • Branch, P., Hampson, R., and Karran, P. DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines. Cancer Res., 55: 2304-2309, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 2304-2309
    • Branch, P.1    Hampson, R.2    Karran, P.3
  • 23
    • 0029565614 scopus 로고
    • A simple, rapid method for isolation of high quality genomic DNA from animal tissues
    • Wu, Q., Chen, M., Buchwald, M., and Phillips, R. A. A simple, rapid method for isolation of high quality genomic DNA from animal tissues. Nucleic Acids Res., 23: 5087-5088, 1995.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 5087-5088
    • Wu, Q.1    Chen, M.2    Buchwald, M.3    Phillips, R.A.4
  • 24
    • 0028961759 scopus 로고
    • A bisulfite method of 5-methylcytosine mapping that minimizes template degradation
    • Raizis, A. M., Schmitt, F., and Jost, J-P. A bisulfite method of 5-methylcytosine mapping that minimizes template degradation. Anal. Biochem., 226: 161-166, 1995.
    • (1995) Anal. Biochem. , vol.226 , pp. 161-166
    • Raizis, A.M.1    Schmitt, F.2    Jost, J.-P.3
  • 25
    • 0031473538 scopus 로고    scopus 로고
    • Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction
    • Wei, Q., Guan, Y., Cheng, L., Radinsky, R., Bar-Eli, M., Tsan, R., Li, L., and Legerski, R. J. Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction. Pathobiology, 65: 293-300, 1997.
    • (1997) Pathobiology , vol.65 , pp. 293-300
    • Wei, Q.1    Guan, Y.2    Cheng, L.3    Radinsky, R.4    Bar-Eli, M.5    Tsan, R.6    Li, L.7    Legerski, R.J.8
  • 26
    • 0030874380 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase (MGMT) CpG island is associated with heterochromatization of the MGMT transcription start site and silencing of the gene
    • 6-methylguanine-DNA methyltransferase (MGMT) CpG island is associated with heterochromatization of the MGMT transcription start site and silencing of the gene. Mol. Cell. Biol., 17: 5612-5619, 1997.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5612-5619
    • Watts, G.S.1    Pieper, R.O.2    Costello, J.F.3    Peng, Y.-M.4    Dalton, W.S.5    Futscher, B.W.6
  • 27
    • 0020644818 scopus 로고
    • 6-methylguanine-DNA methyltransferase of human lymphoid cells:Structural and kinetic properties and absence in repair-deficient cells
    • 6-methylguanine-DNA methyltransferase of human lymphoid cells:structural and kinetic properties and absence in repair-deficient cells. Cancer Res., 43: 3247-3252, 1983.
    • (1983) Cancer Res. , vol.43 , pp. 3247-3252
    • Harris, A.L.1    Karran, P.2    Lindahl, T.3
  • 28
    • 0027502938 scopus 로고
    • Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
    • Branch, P., Aquilina, G., Bignami, M., and Karran, P. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature (Lond.), 362: 652-654, 1993.
    • (1993) Nature (Lond.) , vol.362 , pp. 652-654
    • Branch, P.1    Aquilina, G.2    Bignami, M.3    Karran, P.4
  • 32
    • 0029933660 scopus 로고    scopus 로고
    • Methylation of transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene
    • Pieper, R. O., Patel, S., Ting, S. A., Futscher, B. W., and Costello, J. F. Methylation of transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene. J. Biol. Chem., 271: 13916-13924, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13916-13924
    • Pieper, R.O.1    Patel, S.2    Ting, S.A.3    Futscher, B.W.4    Costello, J.F.5
  • 33
    • 0030879709 scopus 로고    scopus 로고
    • 6-methylguanine DNA methyltransferase gene is associated with the loss of nucleosome-1 like positioning
    • 6-methylguanine DNA methyltransferase gene is associated with the loss of nucleosome-1 like positioning. Mol. Cell. Biol., 17: 5813-5822, 1997.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5813-5822
    • Patel, S.A.1    Graunke, D.M.2    Pieper, R.O.3
  • 37
    • 0032969319 scopus 로고    scopus 로고
    • A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers
    • Herfarth, K. K-F., Brent, T. P., Danam, R. P., Remack, J. S., Kodner, I. J., Wells, S. A., and Goodfellow, P. J. A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers. Mol. Carcinog., 24: 90-98, 1999.
    • (1999) Mol. Carcinog. , vol.24 , pp. 90-98
    • Herfarth, K.K.-F.1    Brent, T.P.2    Danam, R.P.3    Remack, J.S.4    Kodner, I.J.5    Wells, S.A.6    Goodfellow, P.J.7
  • 38
    • 0030472346 scopus 로고    scopus 로고
    • Mismatch repair and cancer
    • Jiricny, J. Mismatch repair and cancer. Cancer Surv., 28: 47-68, 1996.
    • (1996) Cancer Surv. , vol.28 , pp. 47-68
    • Jiricny, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.