Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes

Blood

Volumn 87, Issue 11, 1996, Pages 4678-4685

  Deveaux, Sophie ^b   Filipe, Anne ^b   Lemarchandel, Valérie ^b   Ghysdael, Jacques ^b   Roméo, Paul Henri ^b   Mignotte, Vincent ^a  

^a HENRI MONDOR HOSPITAL   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; ONCOPROTEIN; THROMBOPOIETIN;

ARTICLE; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; GROWTH REGULATION; HUMAN; MEGAKARYOPOIESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION;

EID: 0029944191     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.11.4678.bloodjournal87114678     Document Type: Article

References (43)

1. Souyri M, Vigon I, Penciolelli J-F, Heard J-M, Tambourin P, Wendling F: A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63:1137, 1990
2. Methia N, Louache F, Vainchenker W, Wendling F: Oligodeoxynucleotide antisense to c-mpl protooncogene inhibit human megakaryopoiesis in vitro. Blood 82:1395, 1993
3. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang W-J, Oles KJ, Hultgren B, Solberg LA Jr, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533, 1994
4. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Dort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC: Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369:568, 1994
5. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
6. Bartley TD, Bogenberger J, Hunt P, Li Y-S, Lu HS, Martin F, Chang MS, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu R-Y, Parker VP, Suggs S, Skrine JD: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117, 1994
7. Wendling F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W: c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571, 1994
8. Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265:1445, 1994
9. Wall L, deBoer E, Grosveld F: The human beta-globin gene 3′ enhancer contains multiple binding sites for an erythroid-specific protein. Genes Dev 2:1089, 1988
10. Roméo P-H, Prandini M-H, Joulin V, Mignotte V, Prenant M, Vainchenker W, Marguerie G, Uzan G: Megakaryocytic and erythrocytic lineages share specific transcription factors. Nature 344:447, 1990
11. Martin DIK, Zon LI, Mutter G, Orkin SH: Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature 344:444, 1990
12. Pevny L, Simon MC, Robertson E, Klein WH, Tsai SF, D'Agati V, Orkin SH, Costantini F: Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349:257, 1991
13. Pevny L, Lin CS, D'Agati V, Simon MC, Orkin SH, Costantini F: Development of hematopoietic cells lacking transcription factor GATA-1. Development 121:163, 1995
14. Lemarchandel V, Ghysdael J, Mignotte V, Rahuel C, Roméo P-H: GATA and Ets cis-acting sequences mediate megakaryocyte-specific expression. Mol Cell Biol 13:668, 1993
15. Mignotte V, Lemarchandel V, Roméo PH: GATA et Ets: Deux familles de déterminants majeurs de la différenciation hématopoïetique. Hématologie 1:19, 1995
16. Merika M, Orkin SH: Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol Cell Biol 15:2437, 1995
17. Pahl HL, Scheibe RJ, Zhang D-E, Chen H-M, Galson DL, Maki RA, Tenen DG: The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter. J Biol Chem 268:5014, 1993
18. Zhang D-E, Hetherington CJ, Chen H-M, Tenen DG: The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor. Mol Cell Biol 14:373, 1994
19. Wang C-Y, Petryniak B, Ho I-C, Thompson CB, Leiden JM: Evolutionarily conserved Ets family members display distinct DNA binding specificities. J Exp Med 175:1391, 1992
20. Mignotte V, Vigor I, Boucher de Crèvecoeur E, Roméo P-H, Lemarchandel V, Chrétien S: Structure and transcription of the human c-mpl gene (MPL). Genomics 20:5, 1994
21. Luckow B, Schütz G: CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res 15:5490, 1987
22. Rahuel C, Vinit M-A, Lemarchandel V, Cartron J-P, Roméo P-H: Erythroid-specific activity of the glycophorin B promoter requires GATA-1 mediated displacement of a repressor. EMBO J 11:4095, 1992
23. Dignam J, Lebowitz R, Roeder R: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475, 1983
24. deBoer E, Antoniou M, Mignotte V, Wall L, Grosveld F: The human β-globin promoter; nuclear protein factors and erythroid specific induction of transcription. EMBO J 7:4203, 1988
25. Bailly R-A, Bosselut R, Zucman J, Cormier F, Delattre O, Roussel M, Thomas G, Ghysdael J: DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. Mol Cell Biol 14:3230, 1994
26. Bosselut R, Duvall JF, Gégonne A, Bailly M, Hémar A, Brady J, Ghysdaël J: The product of the c-ets-1 proto-oncogene and the related Ets 2 protein act as transcriptional activators of the long terminal repeat of human T-cell leukaemia virus HTLV-1. EMBO J 9:3137, 1990
27. Mignotte V, Wall L, deBoer E, Grosveld F, Roméo P-H: Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene. Nucleic Acids Res 17:37, 1989
28. Merika M, Orkin S: DNA-binding specificity of GATA family transcription factors. Mol Cell Biol 13:3999, 1993
29. Hickey MJ, Roth GJ: Characterization of the gene encoding human platelet glycoprotein IX. J Biol Chem 268:3438, 1993
30. Lanza F, Morales M, de la Salle C, Cazenave J-P, Clemetson KJ, Shimomura T, Phillips DR: Cloning and characterization of the gene encoding the human platelet glycoprotein V. J Biol Chem 268:20801, 1993
31. Prandini M-H, Uzan G, Martin F, Thevenon D, Marguerie G: Characterization of a specific erythromegakaryocytic enhancer within the glycoprotein IIb promoter. J Biol Chem 267:10370, 1992
32. Ravid K, Doi T, Beeler DL, Kuter DJ, Rosenberg RD: Transcriptional regulation of the rat platelet factor 4 gene: Interaction between and enhancer/silencer domain and the GATA site. Mol Cell Biol 11:6116, 1991
33. Block KL, Ravid K, Phung QH, Poncz M: Characterization of regulatory elements in the 5′-flanking region of the rat GpIIb gene by studies in a primary rat marrow culture system. Blood 84:3385, 1994
34. Zhang L, Lemarchandel V, Roméo P-H, Ben-David Y, Greer P, Bernstein A: The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing's sarcoma, encodes a transcriptional activator with DNA-binding specificities distinct from other Ets family members. Oncogene 8:1621, 1993
35. Wasylyk B, Hahn SL, Giovane A: The Ets family of transcription factors. Eur J Biochem 211:7, 1993
36. McDonald TP, Sullivan PS: Megakaryocytic and erythrocytic cell lines share a common precursor cell. Exp Hematol 21:1316, 1993
37. - mouse embryonic stem cells. Nature Genet 1:92, 1992
38. - embryonic stem cells. Genes Devel 8:1184, 1994
39. Debili N, Wendling F, Cosman D, Titeux M, Florindo C, Dusanter-Fourt I, Schooley K, Methia N, Charon M, Nador R, Bettaieb A, Vainchenker W: The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets. Blood 85:391, 1995
40. Scott EW, Simon MC, Anastasi J, Singh H: Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265:1573, 1994
41. Monté D, Baert JL, Defossez PA, de Launoit Y, Stéhelin D: Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors. Oncogene 9:1397, 1994
42. Breton-Gorius J, Favier R, Guichard J, Cherif D, Berger R, Debili N, Vainchenker W, Douay L: A new congenital dysmegakaryopoietic thrombocytopenia (Paris-Trousseau) associated with giant platelet α-granules and chromosome 11 deletion at 11q23. Blood 85:1805, 1994
43. Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJM, Orkin SH: Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell 81:695, 1995