PMA-induced megakaryocytic differentiation of HEL cells is accompanied by striking modifications of protein kinase C catalytic activity and isoform composition at the nuclear level

British Journal of Haematology

Volumn 92, Issue 3, 1996, Pages 530-536

  Zauli, Giorgio ^a,c   Bassini, Alessandra ^b   Catani, Lucia ^b   Gibellini, Davide ^b   Celeghini, Claudio ^a   Borgatti, Paola ^a   Caramelli, Elisabetta ^b   Guidotti, Lia ^b   Capitani, Silvano ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c Institute of Human Anatomy   (Italy)

Author keywords

HEL; Megakaryocyte differentiation; Nucleus; PKC; PMA

Indexed keywords

HEMIN; ISOENZYME; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ARTICLE; CELL DIFFERENTIATION; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MEGAKARYOCYTE; PRIORITY JOURNAL;

EID: 0030004864     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.00384.x     Document Type: Article

References (33)

1. Alitalo, R., Partanen, J., Pertovaara, L., Holtta, E., Sistonen, L., Anderson, L. & Alifalo, K. (1990) Increased erythroid potentiating activity/tissue inhibitor of metalloproteinases and jun/fos transcription factor complex characterize tumor promoter-induced megakaryoblastic differentiation of K562 leukaemia cells. Blood, 75, 1974-1982.
2. Cambier, J.C., Newell, M.K., Justement, L.B., McGuire, J.C., Leach, K.L. & Chen, Z.Z. (1987) Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes. Nature, 327, 629-632.
3. Capitani, S., Girard, P.R., Mazzei, G.J., Kuo, J.F., Berezney, R. & Manzoli, F.A. (1987) Immunochemical characterization of protein kinase C in rat liver nuclei and subnuclear fractions. Biochemical and Biophysical Research Communications, 142, 367-375.
4. Dai, W. & Murphy, M.J. (1993) Downregulation of GATA-1 expression during phorbol myristate acetate-induced megakaryocytic differentiation of human erythroleukemia cells. Blood, 81, 1214-1221.
5. Dekker, L.V. & Parker, P.J. (1994) Protein kinase C: a question of specificity. Trends in Biochemical Sciences 19, 73-77.
6. Drexler, H.G., Gaedicke, G. & Minowada, J. (1986) Erythroleukemia cell lines HEL and K-562: changes in isoenzyme profiles and morphology during induction of differentiation. Hematology/Oncology, 4, 163-169.
7. Fields, A.P., Tyler, G., Kraft, A.S. & May, W.S. (1990) Role of nuclear protein kinase C in the mitogenic response to platelet-derived growth factor. Journal of Cell Science, 96, 107-114.
8. Grabarek, J., Raychowdhury, M., Ravid, K., Kent, C., Newman, P. & Ware, J.A. (1992) Identification and functional characterization of protein kinase C isoenzymes in platelets and HEL cells. Journal of Biological Chemistry, 267, 10011-10017.
9. Hocevar, B.A. & Fields, A.P. (1991) Selective translocation of βII-protein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells. Journal of Biological Chemistry, 266, 28-33.
10. Hoffman, R. (1989) Regulation of megakaryocytopoiesis. Blood, 74, 1196-1212.
11. Hug, H. & Sarre, T.F. (1993) Protein kinase C isoenzymes: divergence in signal tranduction? Biochemical Journal, 291, 329-345.
12. Kiley, S.C. & Jaken, S. (1994) Protein kinase C: interactions and consequences. Trends in Cell Biology, 4, 223-227.
13. Kiley, S.C. & Parker, P.J. (1998) Differential localization of protein kinase C isoenzymes in U937 cells: evidence for distinct isoenzyme functions during monocyte differentiation. Journal of Cell Science, 108, 1003-1016.
14. Leach, K.L., Powers, E.A., Ruff, V.A., Jaken, S. & Kaufmann, S. (1989) Type 3 protein kinase C localization to the nuclear envelope of phorbol ester-treated N1H 3T3 cells. Journal of Cell Biology, 109, 685-695.
15. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 277, 680-85.
16. Long, M.W., Heffner, C.H., Williams, J.L., Peters, C. & Prochownik, E.V. (1990) Regulation of megakaryocyte phenotype in human erythroleukemia cells. Journal of Clinical Investigation, 85, 1072-1080, 1990.
17. Lozzio, C.B. & Lozzio, B.B. (1975) Human chronic myelogeneous leukemia cell line with positive Philadelphia chromosome. Blood, 45, 321-333.
18. Lumelsky, N. & Forget, B. (1991) Negative regulation of globin gene expression during megakaryocytic differentiation of a human erythroleukemic cell line. Molecular Cell Biology, 11, 3528-3535.
19. Marks, P.A., Sheffery, M. & Rifkind, R.A. (1987) Induction of transformed cells to terminal differentiation and the modulation of gene expression. Cancer Research, 47, 659-666.
20. Martin, P. & Papayannopoulou, T. (1982) HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin expression. Science, 216, 1233-1235.
21. Mazzoni, M., Bertagnolo, V., Neri, L.M., Carini, C., Marchisio, M., Milani, D., Manzoli, F.A. & Capitani, S. (1992a) Discrete subcellular localization of phosphoinositidase C β, γ and δ in PC 12 rat pheochromocytoma cells. Biochemical and Biophysical Research Communications, 187, 114-20.
22. Mazzoni, M., Carini, C., Matteucci, A., Martelli, A.M., Bertagnolo, V., Previati, M., Rana, R., Cataldi, A. & Capitani, S. (1992b) Increased phosphorylation of nuclear substrates for rat brain protein kinase C in regenerating rat liver nuclei. Cellular Signaling, 4, 313-319.
23. Mischak, H., Goodnight, J., Kolch, W., Martiny-Baron, G., Schaechtle, C., Kazanietz, M.G., Blumberg, P.M., Pierce, J.H. & Mushinski, J.F. (1993a) Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependance, and tumorigenidty. Journal of Biological Chemistry, 268, 20110-20115.
24. Mischak, H., Pierce, J.H., Goodnight, J., Kazanietz, M.G., Blumberg, P.M. & Mushinski, J.F. (1993b) Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-α and -δ and not by protein kinase C-βII, -ε, ζ, and -η Journal of Biological Chemistry, 268, 20110-20115.
25. Murate, T., Saga, S., Hotta, T., Asano, H., Ito, T., Kato, K., Tsushita, K., Kinoshita, T., Ichikawa, A., Yoshida, S. & Saito, H. (1993) The close relationship between DNA replication and the selection of differentiation lineages of human erythroleukemia cell lines K562, HEL and TF-1 into either erythroid or megakaryocytic lineages. Experimental Cell Research, 208, 35-43.
26. Murray, N.R., Baumgardner, G.P., Burns, D.J. & Fields, A.P. (1993) Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Journal of Biological Chemistry, 268, 15847-15853.
27. Murti, G.K., Kuljeet, K. & Goorha, K.M. (1992) Protein kinase C associates with intermediate filaments. Experimental Cell Research, 207, 183-188.
28. Namciu, S., Lieberman, M.A. & Stavnezer, E. (1994) Induction of the c-ski proto-oncogene by phorbol ester correlates with induction of megakaryocyte differentiation. Oncogene, 9, 1407-1416.
29. Nishizuka, Y. (1986) Studies and perspectives of protein kinase C. Science, 233, 305-312.
30. Olson, E.N., Burgess, R. & Staudlinger, J. (1993) Protein kinase C as a tranducer of nuclear signals. Cell Growth and Differentiation, 4, 699-705.
31. Rinaudo, M.S., Su, K., Falk, L.A., Haldar, S. & Mufton, R.A. (1995) Human interleukin-3 receptor modulates bcl-2 mRNA and protein levels through protein kinase C in TF-1 cells. Blood, 86, 80-88.
32. Tabilio, A., Rosa, J.P., Testa, U., Kieffer, N., Nurden, A.T., Del Canizo, M.C., Breton-Gorius, J. & Vainchenker, W. (1984) Expression of platelet membrane glycoproteins and a-granule proteins by a human erythroleukemia cell line (HEL). EMBO Journal, 3, 453-459.
33. Yen, A., Varvayanis, S. & Platko, J.D. (1993) 12-0-Tetradecanoyl-phorbol-13-acetate and staurosporine induce increased retinoblastoma tumor suppressor gene expression with megakaryocytic differentiation of leukemic cells. Cancer Research, 53, 3085-3091.