Among substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomolar range of daunorubicin in vitro

Anti-Cancer Drugs

Volumn 13, Issue 6, 2002, Pages 567-581

  Perchellet, Elisabeth M ^a   Sperfslage, Bonnie J ^a   Wang, Yang ^a   Huang, Xiaodong ^a   Tamura, Masafumi ^a   Hua, Duy H ^a   Perchellet, Jean Pierre ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; DNA synthesis and fragmentation; L1210 cells; Nucleoside transport; Triptycene bisquinones; Tumor cell viability

Indexed keywords

2 BROMO 3 METHOXY 9,10 DIHYDRO 9,10 [1',2']BENZENOANTHRACENE 1,4,5,8 TETRAONE; 2 METHOXY 9,10 DIHYDRO 9,10 [1',2']BENZENOANTHRACENE 1,4,5,8 TETRAONE; 6 BROMO 7 METHOXY 2 N DIMETHYLAMINO 9,10 DIHYDRO 9,10 [1',2']BENZENOANTHRACENE 1,4,5,8 TETRAONE; 6 BROMO 7 METHOXY 2 N METHYLAMINO 9,10 DIHYDRO 9,10 [1',2']BENZENOANTHRACENE 1,4,5,8 TETRAONE; 7 BROMO 6 METHOXY 2 N DIMETHYLAMINO 9,10 DIHYDRO 9,10 [1',2']BENZENOANTHRACENE 1,4,5,8 TETRAONE; 7 BROMO 6 METHOXY 2 N METHYLAMINO 9,10 DIHYDRO 9,10 [1',2']BENZENOANTHRACENE 1,4,5,8 TETRAONE; 9,10 DIHYDRO 9,10 [1,2]BENZENOANTHRACENE 1,4,5,8 TETRAONE; ANTHRACYCLINE ANTIBIOTIC AGENT; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTIC ACID FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CYCLOHEXIMIDE; DACTINOMYCIN; DAUNORUBICIN; DNA FRAGMENT; ENDONUCLEASE; ETHYL 3 [N (3 BROMO 1,4,5,8 TETRAOXO 9,10 DIHYDRO 9,10 [1',2']BENZENOANTHRACEN 2 YL)]AMINOPROPANOATE; TERT BUTYL 3 [N (3 BROMO 1,4,5,8 TETRAOXO 9,10 DIHYDRO 9,10 [1',2']BENZENOANTHRACEN 2 YL)]AMINOPROPANOATE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TRIPTYCENE DERIVATIVE; UNCLASSIFIED DRUG; ZINC SULFATE; 6 BROMO 7 METHOXY 2 N METHYLAMINO 1H,4H,5H,8H 9,10 DIHYDRO 9,10 (1',2')BENZENOANTHRACENE 1,4,5,8 TETRAONE; 6-BROMO-7-METHOXY-2-N-METHYLAMINO-1H,4H,5H,8H-9,10-DIHYDRO-9,10-(1',2')BENZENOANTHRACENE-1,4,5,8-TETRAONE; 7 BROMO 6 METHOXY 2 N METHYLAMINO 1H,4H,5H,8H 9,10 DIHYDRO 9,10 (1',2')BENZENOANTHRACENE 1,4,5,8 TETRAONE; 7-BROMO-6-METHOXY-2-N-METHYLAMINO-1H,4H,5H,8H-9,10-DIHYDRO-9,10-(1',2')BENZENOANTHRACENE-1,4,5,8-TETRAONE; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; BRIDGED COMPOUND; DNA; NUCLEOSIDE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CHROMATIN CONDENSATION; COMBINATION CHEMOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DNA DAMAGE; DRUG POTENCY; ENZYME ACTIVATION; IN VITRO STUDY; LEUKEMIA L 1210; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOSIDE TRANSPORT; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; CELL SURVIVAL; DRUG EFFECT; HUMAN; METABOLISM;

ANIMAL; ANTHRAQUINONES; ANTIBIOTICS, ANTHRACYCLINE; ANTINEOPLASTIC AGENTS; APOPTOSIS; BRIDGED COMPOUNDS; CELL SURVIVAL; DAUNORUBICIN; DNA FRAGMENTATION; DNA, NEOPLASM; HUMAN; LEUKEMIA L1210; NUCLEOSIDES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; HUMANS;

EID: 0036021016     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200207000-00003     Document Type: Article

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