Antileukemic activity of synthetic daunomycinone derivatives bearing modifications in the glycosidic moiety

Anticancer Research

Volumn 21, Issue 6 A, 2001, Pages 3957-3967

  Perchellet, Elisabeth M ^a   Sperfslage, Bonnie J ^a   McIlvain, Corbin J ^a   Aligiannis, Nectarios ^a   Pouli, Nicole ^a   Marakos, Panagiotis ^a   Skaltsounis, Alexios Leandros ^a   Perchellet, Jean Pierre ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Daunomycinone derivatives; DNA cleavage; L1210 cells; Macromolecule synthesis; Mitotic index; Nucleoside transport; Tumor cell growth and viability

Indexed keywords

3' CHLORO 3' DEAMINO 4' DEOXY 4' TRIFLUOROACETAMIDODAUNORUBICIN; 4' AZIDO 3' CHLORO 3' DEAMINO 4' DEOXYDAUNORUBICIN; ANTINEOPLASTIC AGENT; DAUNOMYCINONE; DAUNORUBICIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CLEAVAGE; DNA STRAND BREAKAGE; DNA SYNTHESIS; DRUG STRUCTURE; DRUG SYNTHESIS; LEUKEMIA; LEUKEMIA L 1210; MOUSE; NONHUMAN; NUCLEOSIDE TRANSPORT; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TUMOR CELL CULTURE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CARRIER PROTEINS; CELL DIVISION; CELL SURVIVAL; DAUNORUBICIN; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSIDES; GROWTH INHIBITORS; LEUKEMIA L1210; MEMBRANE PROTEINS; MITOSIS; NEOPLASM PROTEINS; NUCLEOSIDE TRANSPORT PROTEINS; RNA, NEOPLASM;

EID: 0035571095     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Bioactivation as a model for drug design bioreductive alkylation
2. Quinone chemistry and toxicity
3. Anthracyclines
4. Quinone toxicity in hepatocytes without oxidative stress
5. Characterization of L5178Y murine lymphoblasts resistant to quinone antitumor agents
6. Anticancer quinones induce pRb-preventable G2/M cell cycle arrest and apoptosis
7. DNA topoisomerase poisons as antitumor drugs
8. Adriamycin-enhanced membrane lipid peroxidation in isolated rat nuclei
9. Modulation of doxorubicin-induced chromosomal damage by calmodulin inhibitors and its relationship to cytotoxicity in progressively doxorubicin-resistant tumor cells
10. Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells
11. Bcl-2 and mdr-1 gene expression during doxorubicin-induced apoptosis in murine leukemic P388 and P388/R84 cells
12. Triptycenes: A novel synthetic class of bifunctional anticancer drugs that inhibit nucleoside transport, induce DNA cleavage and decrease the viability of leukemic cells in the nanomolar range in vitro
13. 1,4-Anthraquinone: An anticancer drug that blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of L1210 leukemic cells in the same nanomolar range as daunorubicin in vitro
14. Quinone isomers of the WS-5995 antibiotics: Synthetic antitumor agents that inhibit macromolecule synthesis, block nucleoside transport, induce DNA fragmentation and decrease the growth and viability of L1210 leukemic cells more effectively than ellagic acid and genistein in vitro
15. Structure-antitumor activity relationships among quinone derivatives
16. Anthraquinone anticancer agents
17. Antineoplastic agents. Structure-activity relationship study of bis (substituted aminoalkylamino) anthraquinones
18. Synthesis and biological activity of 4′-azido- and 4′-trifluoracetamido-3′-chloro-3′-deamino-4′- deoxydaunorubicin
19. Synthesis and biological activity of 3′-deamino-3′-haloanthracyclines
20. Influence of lipophilicity on cytotoxicity of anthracyclines in LoVo and LoVo/Dx human cell lines
21. Further examination of 9-alkyl- and sugar-modified anthracyclines in the circumvention of multidrug resistance
22. Tricyclic pyrone analogs: A new synthetic class of bifunctional anticancer drugs that inhibit nucleoside transport, microtubule assembly, the viability of leukemic cells in vitro and the growth of solid tumors in vivo
23. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture
24. BIBW 22, a dipyridamole analogue, acts as a bifunctional modulator on tumor cells by influencing both P-glycoprotein and nucleoside transport
25. S-phase arrest by nucleoside analogues and abrogation of survival without cell cycle progression by 7-hydroxystaurosporine
26. Cytochalasin B induces cellular DNA fragmentation
27. A simple salting out procedure for extracting DNA from human nucleated cells
28. Induction of apoptosis in human leukemic U937 cells by tetandrine
29. Design, synthesis and biological activity of 7-O-(4-O-acetyl-3-iodo-2,3,6-trideoxy-α-L-arabino-hexopyranosyl) daunomycinone and 7-O-(3-chloro-2,3,6-trideoxy-4-O-propanoyl-α-L-lyhexopyranosyl) daunomycinone
30. Synthesis and study of structure-activity relationships of new classes of anthracyclines
31. Isodoxorubicin: Biological profile of a new doxorubicin derivative
32. Role of the sugar moiety in the pharmacological activity of anthracyclines: Development of a novel series of disaccharide analogs
33. NCI's anticancer drug screening program may not be selecting for clinically active compounds
34. Biochemical pathways of caspase activation during apoptosis
35. Induction of apoptosis by cancer chemotherapy
36. Apoptotic DNA fragmentation