Antiproliferative effects of compounds derived from plants of Northeast Brazil

Phytotherapy Research

Volumn 14, Issue 3, 2000, Pages 187-191

  Pessoa, C ^a   Silveira, E R ^a   Lemos, T L G ^a   Wetmore, L A ^c   Moraes, M O ^a   Leyva, A ^b,c  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b CHILDREN S MERCY HOSPITAL   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

12 Acetoxy hawtriwaic acid lactone; Auxemma oncalyx; Egletes viscosa; Natural products; Oncocalyxones; Ternatin

Indexed keywords

ANTHRAQUINONE DERIVATIVE; AUXEMMA ONCOCALYX EXTRACT; BREDEMEYRA FLORIBUNDA EXTRACT; BROSIMUM RUBESCENS EXTRACT; CROTON SONDERIANUS EXTRACT; DIPTERYX LACUNIFERA EXTRACT; DITERPENE; DNA; EGLETES VISCOSA EXTRACT; FLAVONE DERIVATIVE; FLAVONOID; LACTONE DERIVATIVE; NATURAL PRODUCT; PLANT EXTRACT; TRIGONIA FASCICULATA EXTRACT; UNCLASSIFIED DRUG; ZANTHOXYLUM GARDNERII EXTRACT;

ARTICLE; CANCER; CELL GROWTH; CELL PROLIFERATION; DNA DAMAGE; DNA SYNTHESIS; DRUG EFFECT; DRUG EXPOSURE; DRUG INHIBITION; DRUG POTENTIATION; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; LUNG TUMOR; NONHUMAN; PHYTOCHEMISTRY; PLANT;

ANTHRAQUINONES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BRAZIL; CELL DIVISION; CELL LINE; CELL SURVIVAL; DITERPENES; FIBROBLASTS; FLAVONOIDS; HUMANS; LEUKEMIA; LUNG NEOPLASMS; PLANTS, MEDICINAL; SKIN; TUMOR CELLS, CULTURED;

ASTERACEAE; AUXEMMA; AUXEMMA ONCOCALYX; BORAGINACEAE; EGLETES VISCOSA;

EID: 0034034172     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1573(200005)14:3<187::AID-PTR572>3.0.CO;2-I     Document Type: Article

References (20)

1. Braga, R. (1953). Plantas do Nordeste, Especialemente do Ceara. Centro de Divulgacao Universitaria, Fortaleza.
2. Hanauske, A. R. (1996). The development of new chemotherapeutic agents. Anticancer Drugs Suppl. 2, 29-32.
3. Kanter, P. M., and Schwartz, H. S. (1983). A fluorescence enhancement assay for cellular DNA damage. Mol. Pharmacol. 22, 145-151.
4. Lima, M. A. S., Silveira, E. R., Marques, M. S. L., Santos, R. H. A., and Gambardela, M. T. P. (1996). Biologically active flavonoids and terpenoids from Egletes viscosa. Phytochemistry 41, 217-223.
5. Magiatis, P., Melliou, E., Skaltsounis, A. L. et al. (1998). Synthesis and cytotoxic activity of pyranocoumarins of the seslin and xanthyletin series. J. Nat. Prod. 61, 982-986.
6. Mendes, F. N. P., and Silveira, E. R. (1994). Fatty acids, sesqui- and diterpenoids from seeds of Dipteryx lacunifera. Phytochemistry 35, 1499-1503.
7. Monks, A., Scudiero, D., Skehan, P. et al. (1991). Feasibility of a high-flux anticancer drug screen utilizing a diverse panel of human tumor cell lines in culture. J. Nat Cancer Inst. 83, 757-766.
8. Moraes, M. O., Fonteles, M. C., Moraes, M. E. A., Machado, M. I. L., and Matos, F. J. A. (1997). Screening for anticancer activity of plants from the Northeast of Brazil. Fitoterapia 68, 234-239.
9. Moran, R., Darzynkiewicz, Z., Staiano-Coico, L., and Melamed, M. R. (1985). Detection of BrdUrd incorporation by monoclonal antibodies: Role of the denaturation step. J. Histochem. Cytochem. 33, 821-827.
10. Pessoa, O. D. L., Lemos, T. L. G., Silveira, E. R., and Braz-Filho, R. (1993). Novel cordiachromes isolated from Auxemma oncocalx. Nat. Prod. Lett. 2, 145-150.
11. Pessoa O. D. L., Lemos, T. L. G., De Carvalho, M. G., and Braz-Filho, R. (1995). Cordiachromes from Auxemma oncocalyx. Phytochemistry 40, 1777-1786.
12. Pezzuto, J. M. (1997). Plant-derived anticancer agents. Biochem. Pharmacol. 53, 121-133.
13. Pieters, R., Huismans, D. R., Leyva, A., and Veerman, A. J. P. (1989). Adaptation of a rapid automated tetrazolium dye based (MTT) assay for chemosensitivity testing in childhood leukemia. Cancer Lett. 41, 323-332.
14. Rao, V. S. N., Santos, F. A., Sobeira, T. T., Souza, M. F., Melo, C. L., and Silveira, E. R. (1997). Investigations on the gastroprotective and antidiarrhoeal properties of ternatin, a tetramethoxyflavone from Egletes viscosa. Planta Med. 63, 146-149.
15. Rao, V. S. N., Figueiredo, E. G., Melo, C. L. et al. (1994). Protective effect of ternatin, a flavonoid isolated from Egletes viscosa Less., in experimental liver injury. Pharmacology 48, 392-397.
16. Silveira, E. R., Falcao, M. F. C., Menezes, Jr., A., Kingston, D. G. I., and Glass, T. E. (1995). Pentaoxygenated xanthones from Bredemeyra floribunda. Phytochemistry 39, 1433-1436.
17. Skehan, P., Storeng, R., Scudiero, D. et al. (1990). New colorimetric cytotoxicity assay for anticancer drug screening. J. Nat. Cancer Inst. 82, 1107-1112.
18. Souza, M. F., Rao, V. S. N., and Silveira, E. R. (1997). Inhibition of lipid peroxidation by ternatin, a tetramethoxyflavone from Egletes viscosa L. Phytomedicine 4, 27-31.
19. Souza Brito, A. R. M., and Souza Brito, A. A. (1993). Forty years of Brazilian medicinal plant research. J. Ethnopharmacol. 39, 53-67.
20. Takeuchi, N., Kasama, T., Aida, Y. et al. (1991). Pharmacological activities of the prenylcoumarins, developed from folk usage as a medicine of Peucedanum japonicum Thunb. Chem. Pharm. Bull. (Tokyo) 39, 1415-1421.