Binding of paxillin to α4 integrins modifies integrin-dependent biological responses

Nature

Volumn 402, Issue 6762, 1999, Pages 676-681

  Liu, Shouchun ^a   Thomas, Shella M ^b   Woodside, Darren G ^a   Rose, David M ^a   Klosses, William B ^a   Pfaff, Martin ^c   Ginsberg, Mark H ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITÉ DE LYON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; PAXILLIN; ALPHA4 INTEGRIN; CELL ADHESION MOLECULE; CYTOSKELETON PROTEIN; DNA BINDING PROTEIN; HYBRID PROTEIN; LEUKOCYTE ANTIGEN; LPXN PROTEIN, HUMAN; LPXN PROTEIN, MOUSE; PHOSPHOPROTEIN; PXN PROTEIN, HUMAN; PXN PROTEIN, MOUSE; SIGNAL PEPTIDE; TGFB1I1 PROTEIN, HUMAN; TGFB1I1 PROTEIN, MOUSE; TYROSINE;

ARTICLE; CELL FUNCTION; EMBRYO DEVELOPMENT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ANIMAL; CELL ADHESION; CELL MOTION; CHO CELL; HAMSTER; LEUKEMIA CELL LINE; METABOLISM; MOLECULAR MIMICRY; MOUSE; PHOSPHORYLATION; PROTEIN BINDING;

ANIMALS; ANTIGENS, CD; CELL ADHESION; CELL ADHESION MOLECULES; CELL MOVEMENT; CHO CELLS; CRICETINAE; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; HUMANS; INTEGRIN ALPHA4; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JURKAT CELLS; MICE; MOLECULAR MIMICRY; PAXILLIN; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; TYROSINE;

EID: 0033539801     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/45264     Document Type: Article

References (30)

1. Stewart, M., Thiel, M. & Hogg, N. Leukocyte integrins. Curr. Opin. Cell Biol. 7, 690-696 (1995).
2. Shimizu, Y., Rose, D. M. & Ginsberg, M. H. Integrins in the immune system. Adv. Immunol. 72, 325-380 (1999).
3. Hemler, M. E., Kassner, P. D. & Chan, B. M. C. Functional roles for integrin alpha subunit tails. Cold Spring Harbor Symposia on Quant. Biol. 57, 213-220 (1992).
4. Pfaff, M., Liu, S., Erle, D. J. & Ginsberg, M. H. Integrin β tails differentially bind to cytoskeletal proteins. J. Biol. Chem. 273, 6104-6109 (1998).
5. Williams, M. J., Hughes, P. E., O'Toole, T. E. & Ginsberg, M. H. The inner world of cell adhesion: integrin tails. Trends Cell Biol. 4, 109-112 (1994).
6. Sastry, S. K. & Horwitz, A. F. Integrin tails: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling. Curr. Opin. Cell Biol. 5, 819-831 (1993).
7. Shibanuma, M. et al. Induction of senesence-like phenotypes by forced expression of the hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts. Mol. Cell. Biol. 17, 1224-1235 (1994).
8. Lipsky, B. P., Beals, C. R. & Staunton, D. E. Leupaxin is a novel LIM domain protein that forms a complex with PYK2. J. Biol. Chem. 273, 11709-11713 (1998).
9. Hagmann, J., Grob, M., Welman, A., van Willigen, G. & Burger, M. M. Recruitment of the LIM protein hic-5 to focal contacts of human platelets. J. Cell Sci. 11, 2181-2188 (1998).
10. Hughes, P. E. et al. Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell 88, 521-530 (1997).
11. Turner, C. E. Paxillin. Int. J. Biochem. Cell Biol. 30, 955-959 (1998).
12. Ilic, D. et al. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539-544 (1995).
13. Cary, L. A., Chang, J. F. & Guan, J.-L. Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J. Cell Sci. 109, 1787-1794 (1996).
14. 4 tail. Mol. Biol. Cell 6, 661-674 (1995).
15. Hemler, M. E. Integrin associated proteins. Curr. Opin. Cell. Biol. 10, 578-585 (1998).
16. Lauffenburger, D. A. & Horwitz, A. F. Cell migration: a physically integrated molecular process. Cell 84, 359-369 (1996).
17. Parsons, J. T. & Parsons, S. J. Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways. Curr. Opin. Cell Biol. 9, 187-192 (1997).
18. Hanks, S. K. & Polte, T. R. Signaling through focal adhesion kinase. Bioessays 19, 137-145 (1997).
19. Klinghoffer, R. A., Sachsenmaier, C., Cooper, J. A. & Soriano, P. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18, 2459-2471 (1999).
20. Fincham, V. J. & Frame, M. C. The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J. 17, 81-92 (1998).
21. Turner, C. E. et al. Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: a role in cytoskeletal remodeling. J. Cell Biol. 145, 851-863 (1999).
22. Shen, Y., Schneider, G., Cloutier, J. F., Veillette, A. & Schaller, M. D. Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin. J. Biol. Chem. 273, 6474-6481 (1998).
23. Angers-Loustau, A. et al. Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J. Cell Biol. 144, 1019-1031 (1999).
24. Klemke, R. L. et al. CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J. Cell Biol. 140, 961-972 (1998).
25. Thomas, S. M., Soriano, P. & Imamoto, A. Specific and redundant roles of Src and Fyn in organizing the cytoskeleton. Nature 376, 267-271 (1995).
26. Salgia, R. et al. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. J. Biol. Chem. 270, 5039-5047 (1995).
27. Chen, Y.-P., O'Toole, T. E., Ylanne, J., Rosa, J.-P. & Ginsberg, M. H. A point mutation in the integrin β3 tail (S752-P) impairs bidirectional signaling through αIIbβ3 (Platelet glycoprotein IIb-IIIa). Blood 84, 1857-1865 (1994).
28. Ylanne, J. et al. Distinct functions of integrin α and β subunit tails in cell spreading and formation of focal adhesions. J. Cell Biol. 122, 223-233 (1993).
29. Gao, J., Zoller, K. E., Ginsberg, M. H., Brugge, J. S. & Shattil, S. J. Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3. EMBO J. 16, 6414-6425 (1997).
30. Mazaki, Y., Uchida, H., Hino, O., Hashmoto, S. & Sabe, H. Paxillin isoforms in mouse. J. Biol. Chem. 273, 22435-22441 (1998).