Design and synthesis of molecular umbrellas

Journal of the American Chemical Society

Volumn 119, Issue 4, 1997, Pages 640-647

  Janout, Vaclav ^a   Lanier, Marion ^a   Regen, Steven L ^a  

^a LEHIGH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLIC ACID DERIVATIVE; SPERMIDINE DERIVATIVE;

ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; FLUORESCENCE; IN VITRO STUDY; REACTION ANALYSIS; SURFACE TENSION;

EID: 0031040423     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja962405i     Document Type: Article

References (19)

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18. max values that were observed at 0.5 and 2.0 μM were 493.5 ± 0.5 and 493.5 ± 0.3 nm, respectively. Although we do not yet understand this phenomenon, we suspect that changes in fluorescent lifetimes and/or aggregation (turbidity) are primary factors that are responsible for this behavior.
19. A widely held view in the drug delivery field is that molecular weight is an important determinant of a molecule's ability to cross a membrane (e.g., Pidgeon, C.; Ong, S.; Liu, H.; Qiu, X.; Pidgeon, M.; Dantzig, A. H.; Munroe, J.; Hornback, W. J.; Kasher, J. S.; Glunz, L.; Szczerba, T. J. Med. Chem. 1995, 38, 590. A comparison of the permeation properties of single-, double-, and tetra-walled umbrellaconjugates should either lend support or dispel this notion.