Enhancing the 'stickiness' of bile acids to cross-linked polymers: A bioconjugate approach to the design of bile acid sequestrants

Bioconjugate Chemistry

Volumn 11, Issue 3, 2000, Pages 397-400

  Zhang, Lan Hui ^a   Janout, Vaclav ^a   Renner, Jodi L ^a   Uragami, Maki ^a   Regen, Steven L ^a  

^a LEHIGH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CROSSLINKING; DIFFUSION IN SOLIDS; PARTICLE SIZE; SODIUM CHLORIDE;

AMINE DERIVATIVES; BILE ACID; BILE ACID SEQUESTRANTS; BIOCONJUGATES; CHLOROMETHYLATED POLYSTYRENE; CHOLIC ACIDS; CROSSLINKED POLYMERS; PARTICLE DIFFUSION; SYNTHESISED; TERTIARY AMINE;

BIOMOLECULES;

EID: 0034071453     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc990151v     Document Type: Article

References (8)

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2. Stedronsky, E. R. (1994) Interaction of bile acids and cholesterol with nonsystemic agents having hypocholesterolemic properties. Biochim. Biophys. Acta 210, 255-287.
3. Johns, W. H., and Bates, T. R. (1970) Quantification of the Binding Tendencies of Cholestyramine II: Mechanism of Interaction with Bile Salt and Fatty Acid Salt Anions. J. Pharm. Sci. 59, 329-333.
4. Regen, S. L., Stedronsky, E. R., Zhang, L. H., and Janout, V. (1998) Kinetics of exchange of a resin-bound bile acid by chloride ion under mild flow conditions. Macromolecules 31, 5542-5545.
5. Hodge, P., and Sherrington, D. C. (1980) Chloromethylation of cross-linked polystyrene. Polymer-Supported Reactions in Organic Synthesis, p 477, John Wiley & Sons, New York.
6. Stewart, J. M., and Young, J. D. (1969) Chloride analysis by the modified Volhard method. Solid-Phase Peptide Synthesis, pp 55-56, W. H. Freeman, San Francisco.
7. Hellferich, F. (1962) Kinetcs. Ion Exchange, pp 250-322, McGraw-Hill, New York.
8. Kressman, T. R. E., and Kitchener, J. A. (1949) Cation exchange with a synthetic phenolsulphonate resin. Discuss. Faraday Soc. 7, 90-104.