Modulation of DOI-induced increases in cortical BDNF expression by group II mGlu receptors

Pharmacology Biochemistry and Behavior

Volumn 73, Issue 2, 2002, Pages 317-326

  Gewirtz, Jonathan C ^a   Chen, Andrew C ^b   Terwilliger, Rose ^a   Duman, Ronald C ^b   Marek, Gerard J ^a  

^a Yale University School of Medicine   (United States)

^b PFIZER INC   (United States)

Author keywords

5 HT2A receptor; 5 Hydroxytryptamine2A receptor; Brain derived neurotrophic factor; Glutamate; Hallucinogenic drugs; Medial prefrontal cortex; Metabotropic glutamate2 3 receptors; mGlu2 receptors; Phenethylamine hallucinogens; Serotonin

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; BRAIN DERIVED NEUROTROPHIC FACTOR; EGLUMETAD; MESSENGER RNA; METABOTROPIC GLUTAMATE RECEPTOR II; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG; 4-IODO-2,5-DIMETHOXYPHENYLISOPROPYLAMINE; AMINO ACID; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; AMPHETAMINE DERIVATIVE; BICYCLO COMPOUND; METABOTROPIC RECEPTOR 2; XANTHENE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; GENETIC TRANSCRIPTION; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; BIOSYNTHESIS; BRAIN CORTEX; DRUG ANTAGONISM; DRUG POTENTIATION; GENETICS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

AMINO ACIDS; AMPHETAMINES; ANIMAL; BICYCLO COMPOUNDS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CEREBRAL CORTEX; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; IN SITU HYBRIDIZATION; MALE; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; XANTHENES; ANIMALS;

EID: 0035996477     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(02)00844-4     Document Type: Article

References (80)

1. Visual phenomenology of the LSD flashback
2. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells
3. 2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release
4. Typical and atypical antipsychotic occupancy of D2 and S2 receptors: An autoradiographic analysis in rat brain
5. 1A receptors mediate opposing responses on membrane excitability in rat association cortex
6. Electrophysiological characterization of 5-hydroxytryptamine-2 receptors in rat medial prefrontal cortex
7. Restricted cortical termination fields of the midline and intralaminar thalamic nuclei in the rat
8. Too much of a good thing?
9. 2 receptors and serotonergic axons in rat neocortex
10. The mGlu2/3 receptor agonists, LY354740 and LY379268, selectively attenuate phencyclidine versus d-amphetamine motor behavior in rats
11. The mGlu2/3 receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing
12. Differential effects of MK-801 on brain-derived neurotrophic factor mRNA levels in different regions of the rat brain
13. Local infusion of brain-derived neurotrophic factor modifies the firing pattern of dorsal raphe serotonergic neurons
14. Effect of serotonin antagonism in schizophrenia: A pilot study with setoperone
15. 2A receptor in the central nervous system of the rat
16. The pharmacologic profile of mirtazepine
17. Decrease in the levels of NGF and BDNF in brains of mice fed a tryptophan-deficient diet
18. Nefazodone: Preclinical pharmacology of a new antidepressant
19. Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family
20. 2A/2C-induced c-fos expression and excitatory responses in the prefrontal cortex
21. Behavioral evidence for interactions between a hallucinogenic drug and group II metabotropic glutamate receptors
22. 2A receptor are insensitive to many of the behavioral and physiological effects of hallucinogens
23. 2 agonists or antagonists?
24. 2 receptors in the medial prefrontal cortex: Behavioral studies
25. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain
26. Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor
27. 2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogens in pyramidal cell apical dendrites
28. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus
29. A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity
30. LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors
31. The involvement of brain-derived neurotrophic factor in hippocampal long-term potentiation revealed by gene targeting experiments
32. 2/1C receptor activation causes a localized expression of the immediate-early gene c-fos in rat brain: Evidence for involvement of dorsal raphe nucleus projection fibres
33. Trophic factors, synaptic plasticity, and memory
34. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors
35. Enhancement of neurotransmitter release induced by brain-derived neurotrophic factor in cultured hippocampal neurons
36. Role of brain-derived neurotrophic factor in the circadian regulation of the suprachiasmatic pacemaker by light
37. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
38. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain
39. 2A receptors on neurons in the rat piriform cortex
40. 5-HT-induced EPSCs in neocortical layer V pyramidal cells: Suppression by μ-opiate receptor activation
41. The electrophysiology of prefrontal 5-HT systems: Therapeutic implications for mood and psychosis
42. 1-adrenoceptor activation induces excitatory postsynaptic currents in layer V pyramidal cells of the medial prefrontal cortex
43. A comparison of trazodone and fluoxetine: Implications for a serotonergic mechanism of antidepressant action
44. 2A and group II metabotropic glutamate receptors in prefrontal cortex
45. A major role for thalamocortical afferents in serotonergic hallucinogen receptor function in neocortex
46. TrkB and TrkC signalling are required for maturation and synaptogenesis of hippocampal connections
47. Neurotrophins regulate dendritic growth in developing visual cortex
48. i values
49. Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats
50. Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): A potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties
51. A metabotropic glutamate agonist regulates neurotrophin messenger RNA in rat forebrain
52. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
53. Neurotrophin effects on survival and expression of cholinergic properties in cultured rat septal neurons under normal and stress conditions
54. Distribution of a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat and mouse: An immunohistochemical study with a monoclonal antibody
55. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice
56. Serotonergic regulation of mRNA expression of Arc, an immediate early gene selectively localized at neuronal dendrites
57. Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice
58. 2 binding affinity
59. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors
60. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors
61. 1A agonists
62. 2A heteroceptors on thalamocortical glutamatergic neurons
63. Psychosis: Pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia
64. BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration
65. Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex
66. Neurotrophins and neuronal plasticity
67. 2A/2C receptor activation is differentially regulated in four regions of rat brain
68. 2 receptor as a site of action for LSD and phenethylamine hallucinogens
69. 2A receptor mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex
70. 2A receptors in the stress-induced down-regulation of brain-derived neurotrophic factor expression in rat hippocampus
71. Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action
72. 2 receptors of normal human brain in vitro
73. Localization of brain-derived neurotropic factor mRNA to neurons in the brain by in situ hybridization
74. Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors
75. 2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats
76. 2A receptors are expressed on pyramidal cells and interneurons in the rat cortex
77. Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors
78. Manipulations of brain 5-HT levels affect gene expression for BDNF in rat brain
79. AMPA receptors mediate serotonin-2A receptor-induced EPSCs in layer V pyramidal cells of prefrontal cortex