Characteristics of ATP-induced current through P2X7 receptor in NG108-15 cells: Unique antagonist sensitivity and lack of pore formation

Japanese Journal of Pharmacology

Volumn 88, Issue 4, 2002, Pages 428-435

  Watano, Tomokazu ^a   Matsuoka, Isao ^a   Kimura, Junko ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Antagonist; ATP; NG108 15 cell; P2X7 receptor; Pore formation

Indexed keywords

ADENOSINE TRIPHOSPHATE; CATION; CIBACRON BLUE F3GA; MEGLUMINE; N [1 [4 (5 ISOQUINOLINESULFONYL) ALPHA METHYLBENZYL] 2 (4 PHENYL 1 PIPERAZINYL)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PURINE P2 RECEPTOR BLOCKING AGENT; PURINE P2X RECEPTOR; PURINE P2X7 RECEPTOR; PURINE P2X7 RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SURAMIN; UNCLASSIFIED DRUG; [N 1 [N METHYL 4 (5 ISOQUINOLINESULFONYL)BENZYL] 2 (4 PHENYLPIPERAZINE)ETHYL] 5 ISOQUINOLINE SULFONAMIDE; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2',3' DIALDEHYDE ATP; 2',3'-DIALDEHYDE ATP; BENZOXAZOLE DERIVATIVE; CIBACRON BLUE F 3GA; DRUG DERIVATIVE; FLUORESCENT DYE; PURINE P2 RECEPTOR; PYRIDOXAL 5 PHOSPHATE; PYRIDOXAL PHOSPHATE-6-AZOPHENYL-2',4'-DISULFONIC ACID; QUINOLINE DERIVATIVE; TRIAZINE DERIVATIVE; YO PRO 1; YO-PRO 1;

ANIMAL CELL; ARTICLE; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL TYPE; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; IC 50; INHIBITION KINETICS; ION CURRENT; MOUSE; NONHUMAN; RAT; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; METABOLISM; PATCH CLAMP; PHYSIOLOGY;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ADENOSINE TRIPHOSPHATE; ANIMALS; BENZOXAZOLES; CATIONS; CELL MEMBRANE PERMEABILITY; FLUORESCENT DYES; MICE; PATCH-CLAMP TECHNIQUES; PYRIDOXAL PHOSPHATE; QUINOLINIUM COMPOUNDS; RATS; RECEPTORS, PURINERGIC P2; SURAMIN; TRIAZINES; TUMOR CELLS, CULTURED;

EID: 0035985277     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.88.428     Document Type: Article

References (41)

1. A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP
2. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
3. 7, receptor
4. 7 purinoceptor: Flow cytometry as a promising practical, reliable tool
5. Nucleotide receptors
6. The ATP4-receptor of rat mast cells
7. ATP-activated nonselective cation current in NG108-15 cells
8. The past, present and future of purine nucleotides as signalling molecules
9. 7)
10. 7. Cloning and expression of a human cDNA
11. Role of the purinergic P2Z receptor in spontaneous cell death in J774 macrophage cultures
12. The P2Z purinoceptor: An intriguing role in immunity, inflammation and cell death
13. Extracellular ATP stimulates adenylyl cyclase and phospholipase C through distinct purinoceptors in NG108-15 cells
14. 7 (P2Z) receptor in N18TG-2 cells and NG108-15 cells
15. Extracellular ATP stimulates calcium influx in neuroblastoma × glioma hybrid NG108-15 cells
16. Two distinct ATP signaling mechanisms in differentiated neuroblastoma × glioma hybrid NG108-15 cells
17. + uptake: Inhibition of fluxes by suramin
18. 7 receptor
19. Two distinct cytosolic calcium responses to extracellular ATP in rat parotid acinar cells
20. The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes
21. 7 nucleotide receptor: High selectivity for the human versus rat receptor homologues
22. The P2Z-purinoceptor of human lymphocytes: Actions of nucleotide agonists and irreversible inhibition by oxidized ATP
23. The role of a purinergic P2Z receptor in calcium-dependent cell killing of isolated rat hepatocytes by extracellular adenosine triphosphate
24. Correlation between adenine nucleotide-induced cyclic AMP elevation and extracellular adenosine formation in NG108-15 cells
25. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
26. Effects of anions on ATP-activated nonselective cation current in NG108-15 cells
27. Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor
28. P2Z adenosine triphosphate receptor activity in cultured human monocyte-derived macrophages
29. 7 purinoceptor in mouse NTW8 microglial cells
30. 7 nucleotide receptor and associated phospholipase D activity by lipopolysaccharide and IFN-gamma in the human THP-1 monocytic cell line
31. Transendothelial migration of lymphocytes in chronic lymphocytic leukaemia is impaired and involved down-regulation of both L-selectin and CD23
32. The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role
33. 7 receptor
34. 7 receptor
35. Differential activation of cation channels and non-selective pores by macrophage P2Z purinergic receptors expressed in Xenopus oocytes
36. Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds
37. Pore dilation of neuronal P2X receptor channels
38. 3 receptors
39. 3 receptors, and P2X receptors in rat nodose neurones
40. 5 receptor subunits reveals a novel ATP-gated ion channel
41. 6 channel subunits coassemble into a novel heteromeric ATP receptor