Subunit H of the V-ATPase involved in endocytosis shows homology to β-adaptins

Molecular Biology of the Cell

Volumn 13, Issue 6, 2002, Pages 2045-2056

  Geyer, Matthias ^a   Fackler, Oliver T ^a   Peterlin, B Matija ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ADENOSINE TRIPHOSPHATASE; BETA ADAPTIN; COAT PROTEIN COMPLEX I; LEUCINE; MEMBRANE PROTEIN; NEF PROTEIN; UNCLASSIFIED DRUG; HYBRID PROTEIN; PROTEIN SUBUNIT; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SACCHAROMYCES CEREVISIAE PROTEIN; VMA13 PROTEIN, S CEREVISIAE;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL VACUOLE; CONSENSUS SEQUENCE; ENDOCYTOSIS; ENZYME SUBUNIT; INTERNALIZATION; MOLECULAR RECOGNITION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT;

ADAPTOR PROTEIN COMPLEX BETA SUBUNITS; AMINO ACID SEQUENCE; CLONING, MOLECULAR; CONSERVED SEQUENCE; ENDOCYTOSIS; GENE PRODUCTS, NEF; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, NON-U.S. GOV'T; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 0035985203     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.02-02-0026     Document Type: Article

References (60)

1. Functional domain mapping of the clathrin-associated adaptor medium chains μ1 and μ2
2. Comparison of ARM and HEAT protein repeats
3. Adaptins. The final recount
4. Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes
5. Molecular bases for the recognition of tyrosine-based sorting signals
6. A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
7. Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis
8. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
9. β-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to β-adaptin
10. A comparison of sequence and structure protein domain families as a basis for structural genomics
11. COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP
12. p21-activated kinase 1 plays a critical role in cellular activation by Nef
13. Leucine-based receptor sorting motifs are dependent on the spacing relative to the plasma membrane
14. Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef
15. Structure-function relationships in HIV-1 Nef
16. A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
17. Topological characteristics of helical repeat proteins
18. The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase
19. Deep-etch visualization of proteins involved in clathrin assembly
20. Clathrin and adaptors
21. +-ATPase subunit required for activity but not assembly of the enzyme complex in Saccharomyces cerevisiae
22. The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains
23. Nef-induced CD4 downregulation, a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP
24. Regulation of V-ATPases by reversible disassembly
25. Linking cargo to vesicle formation-receptor tail interactions with coat proteins
26. Adaptors for clathrin-mediated traffic
27. Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian Importin α
28. A simple method for displaying the hydropathic character of a protein
29. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
30. A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains
31. Mutations in the cytoplasmic domain of the 275 kd Mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis
32. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4
33. Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity
34. Protein targeting by tyrosine- and di-leucine-based signals: Evidence for distinct saturable components
35. The structural era of endocytosis
36. Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction
37. Acidification of the endocytic and exocytic pathways
38. Endocytosis and molecular sorting
39. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
40. The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein
41. +)-ATPases - Nature's most versatile proton pumps
42. Interaction of tyrosine-based sorting signals with clathrin-associated proteins
43. A structural explanation for the recognition of tyrosine-based endocytotic signals
44. Clathrin coat construction in endocytosis
45. Nef-induced CD4 degradation: A di-acidic-based motif in Nef functions as a lysosomal targeting signal through the binding of β-COP in endosomes
46. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
47. Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation
48. Sorting of mannose 6-phosphate receptors mediated by the GGAs
49. Dileucine-based sorting signals bind to the β chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site
50. Crystal structure of the regulatory subunit H of the V-type ATPase of Saccharomyces cerevisiae
51. Clathrin-coated vesicle formation and protein sorting: An integrated process
52. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
53. A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin coated vesicle coat protein β-adaptin
54. A clathrin-binding site in the hinge of the β-2 chain of mammalian AP-2 complexes
55. +)-ATPase
56. Peptide-in-groove interactions link target proteins to the β-propeller of clathrin
57. Protein folds, functions and evolution
58. Clathrin-associated adaptor proteins-putting it all together
59. In vivo phosphorylation of adaptors regulates their interaction with clathrin
60. Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor