Enzymatic activation of endothelial protease-activated receptors is dependent on artery diameter in human and porcine isolated coronary arteries

British Journal of Pharmacology

Volumn 136, Issue 4, 2002, Pages 492-501

  Hamilton, Justin R ^a,b   Moffatt, James D ^a   Tatoulis, James ^b   Cocks, Thomas M ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Endothelium; Human coronary artery; Protease activated receptors; Smooth muscle relaxation; Thrombin; Trypsin

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; BOSENTAN; ICATIBANT; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR ACTIVATING PEPTIDE; SERYLLEUCYLISOLEUCYLGLYCYLLYSYLVALINE; SYNTHETIC PEPTIDE; THREONYLPHENYLALANYLLEUCYLLEUCYLARGININE; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG; OLIGOPEPTIDE; PAR 1 ACTIVATING PEPTIDE; PAR-1-ACTIVATING PEPTIDE; SERYL LEUCYL ISOLEUCYL GLYCYL LYSYL VALINE; SERYL-LEUCYL-ISOLEUCYL--GLYCYL-LYSYL-VALINE; THROMBIN RECEPTOR;

ADULT; AGED; ANIMAL TISSUE; ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; BLOOD VESSEL REACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; ENZYME ACTIVATION; EPICARDIUM; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; ISOLATED ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SWINE; VASCULAR ENDOTHELIUM; VASODILATATION; ANIMAL; CORONARY BLOOD VESSEL; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; HEART CONTRACTION; HEART MUSCLE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; METABOLISM; MIDDLE AGED; MUSCLE ISOMETRIC CONTRACTION; PERICARDIUM; PHYSIOLOGY; SPECIES DIFFERENCE;

ADULT; AGED; ANIMAL; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO; ISOMETRIC CONTRACTION; MALE; MIDDLE AGE; MYOCARDIAL CONTRACTION; MYOCARDIUM; OLIGOPEPTIDES; PERICARDIUM; RECEPTORS, THROMBIN; SPECIES SPECIFICITY; SUPPORT, NON-U.S. GOV'T; SWINE; THROMBIN; TRYPSIN; ANIMALS; HUMANS; MIDDLE AGED; RECEPTOR, PAR-1; RECEPTOR, PAR-2;

EID: 0035984932     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704714     Document Type: Article

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