S(+)-4-(1-phenylethylamino)quinazolines as inhibitors of human immunoglobuline E synthesis: Potency is dictated by stereochemistry and atomic point charges at N-1

Journal of Medicinal Chemistry

Volumn 44, Issue 18, 2001, Pages 3031-3038

  Berger, M ^a,b   Albrecht, B ^a   Berces, A ^a   Ettmayer, P ^a   Neruda, W ^a   Woisetschlager M ^a  

^a Brunnerstra e 59   (Austria)

^b Intervet   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ARALKYLAMINE; IMMUNOGLOBULIN E; INTERLEUKIN 4; PHENETHYLAMINE DERIVATIVE; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE;

ALLERGIC DISEASE; ARTICLE; CELL VIABILITY; DOSE RESPONSE; DRUG POTENCY; DRUG STRUCTURE; ENANTIOMER; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; LIPOPHILICITY; QUANTUM MECHANICS; STEREOCHEMISTRY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; B-LYMPHOCYTES; BLOTTING, NORTHERN; CELL LINE; DEPRESSION, CHEMICAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENES, REPORTER; GERM CELLS; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-4; LUCIFERASES; MICE; MICE, INBRED BALB C; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; REPRODUCIBILITY OF RESULTS; SPLEEN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 0035974653     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010888h     Document Type: Article

References (44)

1. Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals
2. Function and regulation of FcεRI expression on monocytes from non-atopic donors
3. Epidermal langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI
4. Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells prior to isotype switching
5. Human recombinant interleukin-4 induces Fc epsilon R2/CD23 on normal human monocytes
6. Induction of Fc epsilon R2/CD23 on human epidermal Langerhan's cells by recombinant interleukin-4 and gamma-interferon
7. Understanding the inflammatory processes in upper allergic airway disease and asthma
8. Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of FcεRI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation
9. Allergen presentation by epidermal Langerhans' cells from patients with atopic dermatitis is mediated by IgE
10. Effect of Suplatast Tosilate (IPD-1151T) on a mouse model of asthma: Inhibition of eosinophilic inflammation and bronchial hyperresponsiveness
11. Effect of suplatast tosylate, a Th2 cytokine inhibitor, on steroid-dependent asthma: A double-blind randomised study
12. Recombinant soluble murine IL-4 receptor can inhibit or enhance IgE responses in vivo
13. In vivo biological effects of recombinant soluble interleukin-4 receptor
14. Inhibition of allergen-induced IgE and IgG1 production by soluble IL-4 receptor
15. IL-4 induces human B-cell maturation and IgE synthesis in SCID-hu mice: Inhibition of ongoing IgE production by in vivo treatment with an IL-4/IL-13 receptor antagonist
16. The interleukin-4-receptor: From recognition mechanism to pharmacological target structure
17. Prevention of the development of immediate hypersensitivity and airway hyperresponsiveness following in vivo treatment with soluble IL-4 receptor
18. An antagonist IL-4 mutant prevents type I allergy in the mouse: Inhibition of the IL-4/IL-13 receptor system completely abrogates humoral immune response to allergen and development of allergic symptoms in vivo
19. Therapeutic potential of anti-IgE antibodies
20. Injection of anti-IgE antibodies will suppress IgE and allergic symptoms
21. Mechanism and regulation of immunoglobulin isotype switching
22. The immunoglobulin class switch: Beyond "accessibility"
23. Immunoglobulin class switching
24. A bifunctional control element in the human IgE germline promoter involved in repression and interleukin 4 activation
25. Cooperation of binding sites for STAT6 and NFκB/rel in the interleukin-4 induced upregulation of the human IgE germline promoter
26. Functional synergism of STAT6 with either NF-kappaB or PU.1 to mediate IL-4 induced activation of IgE germline gene transcription
27. Modulation of IL-4 induced germline epsilon RNA synthesis in human B cells by tumor necrosis factor-alpha, anti-CD40 monoclonal antibodies or transforming growth factor-beta correlates with levels of IgE production
28. Recent advances in polymer-assisted solution-phase chemical library synthesis and purification
29. Solid-supported reagent strategies for rapid purification of combinatorial synthesis products
30. Combinatorial synthesis of dihydropyridone libraries and their derivatives
31. Enantioselective inhibition of the epidermal growth factor receptor tyrosine kinase by 4-(α-phenethylamino)quinazolines
32. Tyrosine kinase inhibitors. 16. 6,5,6-tricyclic enzothieno[2,3-d]pyrimidines and pyrimido[5,4-b]- and -84,5-b]indoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinase
33. ATP site-directed competitive and irreversible inhibitors of protein kinases
34. Inhibitors of NADH - Ubiquinone reductase: An overview
35. Tyrphostins IV - Highly potent inhibitors of EGF receptor kinase. Structure - Activity relationship study of 4-anilidoquinazolines
36. The Merck force field
37. Accurate spin-dependent electron liquid correlation energies for local spin density calculations: A critical analysis
38. Correlation energy of an inhomogeneous electron gas: A coordinate space model
39. Density-functional approximation for the correlation energy of the inhomogeneous elctron gas
40. Electronic population analysis on LCAO-MO (linear combination of atomic orbitals) wave function (I)