Non-thiol farnesyltransferase inhibitors: The concept of benzophenone- based bisubstrate analogue farnesyltransferase inhibitors

European Journal of Medicinal Chemistry

Volumn 35, Issue 7-8, 2000, Pages 721-726

  Schlitzer, Martin ^a   Sattler, Isabel ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

Author keywords

Benzophenones; Bisubstrate analogues; Farnesyltransferase; Non thiol farnesyltransferase inhibitors

Indexed keywords

ALKYL GROUP; BENZOPHENONE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; THIOL;

ARTICLE; CANCER CHEMOTHERAPY; DRUG BINDING SITE; DRUG POTENCY; DRUG STRUCTURE; NONHUMAN; REACTION ANALYSIS;

EID: 0033929812     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)00162-8     Document Type: Article

References (14)

1. McCormick K.G. Trends Biochem. Sci. 24:1999;M53-M56.
2. Macara I.G., Lounsbury K.M., Richards S.A., McKiernan C., Bar-Sari D. FASEB J. 10:1996;625-630.
3. Gomez J., Martinez A.C., Gonzalez A., Rebollo A. Immunol. Cell Biol. 76:1998;125-134.
4. Zhang F.L., Casey P.J. Annu. Rev. Biochem. 65:1996;241-269.
5. Leonard D.M. J. Med. Chem. 40:1997;2971-2990.
6. Sebti S.M., Hamilton A.D. DDT. 3:1998;26-32.
7. Qian Y., Sebti S.M., Hamilton A.D. Biopolymers. 43:1997;25-41.
8. Cox A.D., Der C.J. Biochim. Biophys. Acta. 1333:1997;F51-F71.
9. Du W., Lebowitz P.F., Prendergast G.C. Mol. Cell. Biol. 19:1999;1831-1840.
10. Schlitzer M., Sattler I., Dahse H.M. Arch. Pharm. Pharm. Med. Chem. 332:1999;124-132.
11. Reynolds J.E.F. Martindale The Extra Pharmacopeia. 31st :1996;821-821 Royal Pharmaceutical Society of Great Britain, London.
12. Pompliano D.L., Gomez R.P., Anthony N.J. J. Am. Chem. Soc. 114:1992;7945-7946.
13. Del Villar K., Mitsuzawa H., Yang W., Sattler I., Tamanoi F. J. Biol. Chem. 272:1997;680-687.
14. Tschantz W.R., Furfine E.S., Casey P.J. J. Biol. Chem. 272:1997;9989-9993.