Modification of cytokine patterns in subjects bearing the HLA-B8,DR3 phenotype: Implications for autoimmunity

Cytokines, Cellular and Molecular Therapy

Volumn 3, Issue 4, 1997, Pages 217-223

  Lio, Domenico ^a   Candore, Giuseppina ^a   Romano, Giuseppina Colonna ^a   D'Anna, Claudia ^a   Gervasi, Francesco ^b   Di Lorenzo, Gabriele ^a   Modica, Maria Assunta ^a   Potestio, Marcella ^a   Caruso, Calogero ^a,c  

^a UNIVERSITY OF PALERMO   (Italy)

^b M Ascoli

^c Istituto di Patologia Generale   (Italy)

Author keywords

Autoimmunity; HLA B8,DR3; Immune response; Type 1 cytokines; Type 2 cytokines

Indexed keywords

CYTOKINE; GAMMA INTERFERON; HLA DR3 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; PHYTOHEMAGGLUTININ;

ARTICLE; AUTOIMMUNITY; DISEASE PREDISPOSITION; HAPLOTYPE; HLA TYPING; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL;

ANIMALS; AUTOIMMUNITY; CYTOKINES; HLA-B8 ANTIGEN; HLA-DR3 ANTIGEN; HUMANS; PHENOTYPE;

EID: 0030665314     PISSN: 13684736     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Dausset J, Contu L, The MHC and the immune response in man. In: Immunology 80. Progress in Immunology IV (ed M Fogerau, J Dausset) 513-29. Academic Press, London, 1980.
2. Nepom GT, The effect of variations in human immune response genes. N Engl J Med (1989) 321 751-2.
3. Benacerraf B, When all is said and done. . . Annu Rev Immunol (1991) 9 1-26.
4. Murray JS, Pfeiffer C, Madri J, Bottomly K, Major histocompatibility complex control of CD4 T cells subset activation. II. A single peptide induces either humoral or cell mediated responses in mice of distinct MHC genotype. Eur J Immunol (1992) 48: 559-64.
5. Kruskall MS, The major histocompatibility complex: the value of the extended haplotypes in the analysis of associated immune disease and disorders. Yale J Biol Med (1990) 63: 477-86.
6. Nepom GT, Erlich, H, MHC class II molecules and autoimmunity. Annu Rev Immunol (1991) 9: 493-525.
7. D'Alfonso S, Colombo G, Della Bella S et al, Association between polymorphisms in the TNF region and sytemic lupus erythematosus in the Italian population. Tissue Antigens (1996) 47: 551-5.
8. Modica MA, Colucci AT, Candore G, Caruso C, The HLA-B8,DR3 haplotype and immune response in healthy subjects. Immunol Infect Dis (1993) 3: 119-27.
9. Modica MA, Zambito MA, Candore G, Caruso C, Markers of T lymphocytes activation in HLA-B8,DR3 positive individuals. Immunobiology (1990) 181: 257-266.
10. Candore G, Cigna D, Gervasi F et al, In vitro cytokine production by HLA-B8,DR3 positive subjects. Autoimmunity (1994) 18: 121-32.
11. Candore G, Cigna D, Todaro M et al, T cell activation antigens HLA-B8,DR3 positive subjects: early antigen expression defect in vitro. Hum Immunol (1995) 42: 289-94.
12. Caruso C, Candore G, Modica MA et al, Major histocompatibility complex regulation of cytokine production. J Interferon Cytokine Res (1996) 16: 983-8.
13. Romagnani S, Biology of human Th1 and Th2 cells. J Clin Immunol (1995) 15: 1-15.
14. Modica MA, Cammarata G, Caruso C, HLA-B8,DR3 phenotype and lymphocytes responses to phytohaemagglutinin. J Immunogenet (1990) 17: 101-7.
15. Hashimoto S, McCombs CC, Michalski JP, Mechanism of a lymphocyte abnormality associated with HLA-B8,DR3 in clinically healthy individuals. Clin Exp Immunol (1989) 76: 317-23.
16. Candore G, Colucci AT, Modica MA, Caruso C, HLA-B8,DR3 T cell impairment is completely restored by in vitro treatment with interleukin-2. Immunopharmacol Immunotoxicol (1991) 13: 551-61.
17. Testi R, D'Ambrosio D, De Maria R, Santoni A, The CD69 receptor: a multipurpose cell surface trigger for hematopoietic cells. Immunol Today (1994) 15: 479-83.
18. Seder RA, Kelsall BL, Jankovic D, Differential role for IL-12 in the maintenance of immune response in infectious versus autoimmune disease. J Immunol (1996) 157: 2745-8.
19. Trinchieri G, Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol (1995) 13: 251-76.
20. Candore G, Colombo A, Colonna Romano G et al, In vitro dissociated production of IL-10 and IL-12 by mononuclear cells (MNC) from HLA-B8,DR3 positive individuals. In: Proceedings of II Roche Symposium, Milan, 25-27 October 1996, Abstract book: 185.
21. Lio D, Gervasi F, D'Anna C et al, Interleukin-12 production by mononuclear cells (MNC) from HLA-B8,DR3. Eur J Immunogenet (1996) 24(Suppl 1): 91.
22. Hashimoto S, Michalski JP, Berman MA, McCombs CC, Mechanism of a lymphocyte abnormality associated with IILA-B8,DR3: role of interleukin-1. Clin Exp Immunol (1990) 79: 227-32.
23. Weaver CT, Unanue ER, T cell induction of membrane IL-1 on macrophages. J Immunol (1986) 137: 3868-73.
24. Lio D, D'Anna C, Gervasi F et al, In vitro impairment of interleukin-5 production in HLA-B8,DR3-positive individuals. Implications for immunoglobulin A synthesis dysfunction. Hum Immunol (1995) 44: 170-4.
25. Lio D, D'Anna C, Leone F et al, Hypothesis: interleukin-5 production impairment can be a key point in the pathogenesis of the MHC-linked selective IgA deficiency. Autoimmunity (in press).
26. + T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-γ and granulocyte/macrophage-colony-stimulating factor but not IL-4. J Immunol (1990) 144: 902-7.
27. Jung T, Schauer U, Riegger C et al, Interleukin-4 and interleukin-5 are rarely coexpressed by human T cells. Eur J Immunol (1995) 25: 2413-18.
28. Modica MA, Freddi S, Caruso C, Blood IgA, IgM and IgE levels are influenced by sex and HLA phenotype. Exp Clin Immunogenet (1989) 6: 251-7.
29. Hammarstrom L, Axelsson U, Bjorkander J et al., HLA antigens in selective IgA deficiency: distribution in healthy donors and patients with recurrent respiratory tract infections. Tissue Antigen (1984) 24: 35-42.
30. Morikawa K, Oseko F, Morikawa S et al, Recombinant IL-5 augments immunoglobulin generation by human B lymphocytes in the presence of IL-2. Cell Immunol (1993) 149: 390-401.
31. Huston MM, More JP, Mettes HJ et al, Human B cells express IL-5 receptor messenger ribonucleic acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella catarrhalis. J Immunol (1996) 156: 1392-401.
32. Colona Romano G, Gervasi F, Potestio M et al, Increased serum levels of TNF-α and cortisol in HLA-B8,DR3 positive subjects. Eur J Immunogenet (1996) 24(Suppl 1): 90.
33. D'Alfonso S, Momigliano-Richiardi PA, A polymorphic variation in a putative regulation box of the TNFA promoter region. Immunogenetics (1994) 30: 150-4.
34. Garcia-Merino A, Alper CA, Usuku K et al, Tumor necrosis factor (TNF) microsatellite haplotypes, susceptibility to diseases associated with the major histocompatibility complex and TNF secretion. Hum Immunol (1996) 50: 11-21.
35. Ramsdell F, Seaman MS, Miller RE et al, Differential ability of Th1 and Th2 cells to express Fas ligand and to undergo activation-induced cell death. Int Immunol (1996) 6: 1545-8.
36. Clerici M, Bevilacqua M, Vago T et al, An immunoendocrinologic hypothesis for HIV infection. Lancet (1994) 343: 1552-3.
37. Reichlin S, Neuroendocrine-immune interactions. N Engl J Med (1993) 329: 1246-53.
38. Chrousos GP, Gold PW, The concepts of stress and stress system disorders. J Am Med Assoc (1992) 267: 1244-52.
39. Gerencer M, Tajic M, Kerhin-Brkljacic V, Kastelan A, An association between serum testosterone level and HLA phenotype. Immunol Lett (1982) 4: 155-6.
40. Candore G, Colonna Romano G, D'Anna C et al, Biological basis of the HLA-B8,DR3 associated progression of acquired immune deficiency virus syndrome. Pathobiology (in press).
41. Caruso C, Bongiardina C, Candore G et al, HLA-B8,DR3 haplotype affects lymphocyte blood levels. Immunol Invest (1997) 26: 333-40.
42. Mosmann TR, Coffman RL, Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol (1989) 7: 145-65.
43. Yewdell JW, Bennick JR, The binary logic of antigen processing and presentation to T cells. Cell (1990) 62: 203-6.
44. Paul WE, Seder RA, Lymphocyte responses and cytokines. Cell (1994) 76: 241-6.
45. Gajewski TF, Schell SR, Fitch FW, Evidence implicating utilization of different T cell receptor-associated signaling pathways by Th1 Th2 clones. J Immunol (1990) 144: 4110-6.
46. Caruso C, Candore G, Cigna D et al, Cytokine production pathway in the elderly. Immunol Res (1996) 15: 84-90.
47. Hashimoto S, McCombs CC, Michalski JP, Evidences for an ongoing role of class I histocompatibility molecules for the production of interleukin-2 in response to suboptimal concentrations of phytohaemoagglutinin. Scand J Immunol (1993) 37: 541-4.
48. Xu X, Beckman I, Dimopulos K et al, Age related changes in the expression of T cell activation antigens following phytohaemoagglutinin stimulation. Exp Clin Immunogenet (1992) 9: 203-11.
49. Colucci AT, Di Lorenzo G, Ingrassia A et al, Blood antiphospholipid antibody levels are influenced by age, sex and HLA-B8,DR3 phenotype. Exp Clin Immunogenet (1992) 9: 72-9.
50. Legrand L, Rivat-Perran L, Hutting C, Daussat J, HLA- and Gm-linked genes affecting the degradation of antigens (sheep red cells) endocytosed by macrophages. Hum Immunol (1982) 4: 1-13.
51. Salmon JE, Kimberly RP, Gibofski A, Fotino M, Altered phagocytosis by monocytes from HLA-B8,DR3 positive healthy adults is Fcg receptor specific. J Immunol (1996) 136: 3625-30.
52. Degli-Esposti MA, Leelayuwat C, Daly LN et al, Updated characterization of the fourth ancestral haplotypes using Asia-Oceania histocompatibility workshop panel. Hum Immunol (1995) 44: 12-18.
53. Romagnani S, Th1 and Th2 in human disease. Clin Immunol Immunopathol (1996) 80: 225-35.
54. Fiorentino DF, Zlotnik A, Vieira P et al, IL-10 acts on the antigen presenting cell to inhibit cytokine production by Th1 cells. J Immunol (1991) 146: 3444-9.
55. Cua DJ, Coffman RL, Stohlman SA, Exposure to T helper 2 cytokines in vivo before encounter with antigen selects for T helper subsets via alterations in antigen-presenting cell function. J Immunol (1996) 157: 2830-6.
56. Caligaris-Cappio F, Bertero MT, Converso M et al, Circulating levels of soluble CD30, a marker of cells producing Th2-type cytokines, are increased in patients with systemic lupus erythematosus and correlate with disease activity. Clin Exp Rheum (1995) 13: 339-43.
57. Yanagi K, Haneji N, Hamano H et al, In vivo role of IL-10 and IL-12 during development of Sjogren syndrome in MLR/1pr mice. Cell Immunol (1996) 168: 243-50.
58. Erb KJ, Ruger B, von Brevern M et al, Constitutive expression of interleukin (IL)-4 in vivo causes autoimmune-type disorders in mice. J Exp Med (1997) 185: 329-39.
59. Erb KJ, Holtschke T, Muth K et al, T cell subset distribution and B cell hyperreactivity in mice expressing interleukin-4 under the control of major hystocompatibility complex class I regulatory sequences. Eur J Immunol (1994) 24: 1143-7.
60. Moller G, Gamma interferon. Immunol Rev (1987) 97: 5-65.
61. Caruso C, Candore G, Colucci AT et al, Natural killer and lymphokine activated killer activity in HLA-B8,DR3 positive subjects. Hum Immunol (1993) 38: 226-30.
62. Rotzschke O, Falk K, Stevanovic S et al, Peptide motifs of closely related HLA class I molecules encompass substantial differences. Eur J Immunol (1992) 22: 2453-9.
63. Malcherek G, Falk K, Rotzschke O et al, Natural peptide ligand motifs of two HLA molecules associated with myasthenia gravis. Int Immunol (1993) 5: 1229-37.
64. Schafer PH, Pierce SK, Jardetzsky TS, The structure of MHC class II: a role for dimer of dimers. Semin Immunol (1995) 7: 389-98.
65. Coffman R, Lebman DA, Rothman P, Mechanism and regulation of immunoglobulin isotype switching. Adv Immunol (1993) 54: 229-70.
66. Bach JF, Caiilat-Zucman, Genetics of autoimmune endocrine disease. Springer Semin Immunopathol (1993) 14: 239-52.
67. Di Lorenzo G, Mansueto P, Melluso M et al, Morphea after silicone gel breast implantation for cosmetic reasons in an HLA-B8,DR3 positive woman. Int Arch Allergy Immunol (1997) 112: 93-5.