A new class of errant DNA polymerases provides candidates for somatic hypermutation

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 355, Issue 1405, 2001, Pages 47-51

  Tippin, B ^a   Goodman, M F ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Error prone DNA polymerase; Somatic hypermutation; UmuC DinB Rad30 Rev1 superfamily

Indexed keywords

DNA DIRECTED DNA POLYMERASE; DNA POLYMERASE IOTA;

BIOCHEMISTRY; BIOLOGICAL MODEL; CLASSIFICATION; HUMAN; METHODOLOGY; MUTATION; PHYSIOLOGY; REVIEW;

BIOCHEMISTRY; DNA-DIRECTED DNA POLYMERASE; HUMANS; MODELS, GENETIC; MUTATION;

EID: 0035966785     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (54)

1. A RecA protein mutant deficient in its interaction with the UmuDC complex
2. Analyzing fidelity of DNA polymerases
3. The dynamic nature of the antibody repertoire
4. Elements regulating somatic hypermutation of an immunoglobulin kappa gene: Critical role for the intron enhancer/matrix attachment region
5. Origin of antibody variation
6. The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation
7. Evolution of somatic hypermutation and gene conversion in adaptive immunity
8. DNA polymerase mu (Pol μ), homologous to TdT, could act as a DNA mutator in eukaryotic cells
9. Mutation induced by DNA damage: A many protein affair
10. Mice reconstituted with DNA polymerase β-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally
11. κ rearrangements: Targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs
12. Targeting of the UmuD, UmuD′, and MucA′ mutagenesis proteins to DNA by RecA protein
13. Clusters of point mutations are found exclusively around rearranged antibody variable genes
14. Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily
15. Patterns of somatic mutations in immunoglobulin variable genes
16. Coping with replication 'train wrecks' in Escherichia coli using pol V, pol II, and RecA proteins
17. Interaction and functional interference of C/EBPβ with octamer factors in immunoglobulin gene transcription
18. Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Pol η
19. The human DINB1 gene encodes the DNA polymerase Pol η
20. Antibody diversity: Somatic hypermutation of rearranged VH genes
21. B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes
22. The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation
23. Boundaries of somatic hypermutation in rearranged immunoglobulin genes: 5′ boundary is near promoter, and 3′ boundary is ∼1 kb from V(D)J gene
24. Genes and antibodies
25. Early onset of somatic hypermutation in immunoglobulin VH genes during the primary immune response
26. The efficiency of antibody affinity maturation: Can the rate of B-cell division be limiting?
27. The absence of the transcription activator TEE3 impairs activation of B cells in vivo
28. Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma
29. Diversity and the genesis of high affinity antibodies
30. Both DNA strands of antibody genes are hypermutation targets
31. Deoxycytidyl transferase activity of yeast REV1 protein
32. Monitoring and interpreting the intrinsic features of somatic hypermutation
33. Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa
34. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
35. Mutation and selection during the secondary response to 2-phenyloxazolone
36. Activity of the purified mutagenesis proteins UmuC, UmuD′, and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III
37. The mutagenic protein UmuC is a DNA polymerase activated by UmuD′, RecA, and SSB and is specialized for translesion replication
38. Transcriptional regulation of B-cell differentiation
39. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
40. Lack of peripheral B cells and severe agammaglobulinemia in mice simultaneously lacking Bruton's tyrosine kinase and the B cell-specific transcriptional coactivator OBF-1
41. Cloning and chromosomal mapping of the human DNA polymerase θ (POLQ), the eighth human DNA polymerase
42. Somatic hypermutation of immunoglobulin kappa may depend on sequences 3′ of C kappa and occurs on passenger transgenes
43. Mechanism of antigen-driven somatic hypermutation of rearranged immunoglobulin V(D)J genes in the mouse
44. The molecular basis of somatic hypermutation of immunoglobulin genes
45. RecA protein of Escherichia coli has a third essential role in SOS mutator activity
46. Transcriptional regulation of the murine 3′ IgH enhancer by OCT-2
47. Biochemical basis of SOS mutagenesis in Escherichia coli reconstitution of in vitro lesion bypass dependent on the UmuD2′C mutagenic complex and RecA protein
48. 2C is an error-prone DNA polymerase, Escherichia coli pol V
49. Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis
50. Pol iota, a remarkably error-prone human DNA polymerase
51. Accumulation of somatic mutants in the B cell compartment after primary immunization with a T-cell dependent antigen
52. The role of promoter-intron interactions in directing hypermutation
53. A plethora of lesion-replicating DNA polymerases
54. Is rapid proliferation in B centroblasts linked to somatic mutation and memory B cell clones?