The role of promoter-intron interactions in directing hypermutation

Current Topics in Microbiology and Immunology

Volumn 229, Issue , 1997, Pages 1-10

  Winter, D B ^a   Sattar, N ^b   Gearhart, P J ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b National Institute of Transplantation Los Angeles   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOPHAGE DNA; IMMUNOGLOBULIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; B LYMPHOCYTE; DNA SEQUENCE; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; INTRON; MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; SOMATIC MUTATION; TRANSGENIC MOUSE;

ANIMALS; DNA; GENES, IMMUNOGLOBULIN; HUMANS; INTRONS; MUTATION; PROMOTER REGIONS (GENETICS);

ANIMALIA; MUS MUSCULUS;

EID: 0031455504     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (12)

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4. Dianda L, Gulbranson-Judge A, Pao W, Hayday AC, MacLennan ICM, Owen MJ (1996) Germinal center formation in mice lacking αβ T cells. Eur J Immunol 26:1603-1607
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8. Giusti AM, Manser T (1993) Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-DNA elements required for somatic mutation. J Exp Med 177:797-809
9. Golding GB, Gearhart PJ, Glickman BW (1987) Patterns of somatic mutations in immunoglobulin variable genes. Genetics 115:169-176
10. Green NS, Sack SZ (1997) Effect of the Bloom's syndrome DNA helicase on Ig hypermutation. Keystone Symposium on B Lymphocytes in Health and Disease. Abstract 420
11. Hackett J, Rogerson BJ, O'Brien RL, Storb U (1990) Analysis of mutations in κ transgenes. J Exp Med 172:131-137
12. Lebecque SG, Gearhart PJ (1990) Boundries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is ∼1 kb from V(D)J gene. J Exp Med 172:1717-1727