Transcriptional regulation of the murine 3' IgH enhancer by OCT-2

Immunity

Volumn 11, Issue 5, 1999, Pages 517-526

  Tang, Hong ^a   Sharp, Phillip A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; DEOXYRIBONUCLEASE I; HOMEODOMAIN PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; INTERLEUKIN 6; OCTAMER TRANSCRIPTION FACTOR 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; BINDING SITE; DNA BINDING; DNA FOOTPRINTING; ENHANCER REGION; GENE DELETION; GENE DISRUPTION; GENE MUTATION; GENE TARGETING; IMMUNOGLOBULIN PRODUCTION; MUTANT; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; REGULATOR GENE; REPORTER GENE; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 0033230355     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80127-2     Document Type: Article

References (65)

1. Annweiler, A., Zwilling, S., Hipskind, R.A., and Wirth, T. (1993). Analysis of transcriptional stimulation by recombinant Oct proteins in a cell-free system. J. Biol. Chem. 268, 2525-2534.
2. Annweiler, A., Zwilling, S., and Wirth, T. (1994). Functional differences between the Oct2 transactivation domains determine the transactivation potential of individual Oct2 isoforms. Nucleic Acids Res. 22, 4250-4258.
3. Arulampalam, V., Grant, P.A., Samuelsson, A., Lendahl, U., and Pettersson, S. (1994). Lipopolysaccharide-dependent transactivation of the temporally regulated immunoglobulin heavy chain 3′ enhancer. Eur. J. Immunol. 24, 1671-1677.
4. Babb, R., Cleary, M.A., and Herr, W. (1997). OCA-B is a functional analog of VP16 but targets a separate surface of the Oct-1 POU domain. Mol. Cell. Biol. 17, 7295-7305.
5. Cepek, K.L., Chasman, D.I., and Sharp, P.A. (1996). Sequence-specific DNA binding of the B cell-specific coactivator OCA-B. Genes Dev. 10, 2079-2088.
6. Chasman, D., Cepek, K., Sharp, P.A., and Pabo, C.O. (1999). Crystal structure of a ternary complex containing an OCA-B peptide, Oct-1, and an octamer element:peptide recognition of a protein-DNA interface. Genes Dev., in press.
7. Chauveau, C., Pinaud, E., and Cogne, M. (1998). Synergy between regulatory elements of the immunoglobulin heavy chain locus and its palindromic 3′ locus control region. Eur. J. Immunol. 28, 3048-3056.
8. Coffman, R.L., Lebman, D.A., and Rothman, P. (1993). Mechanism and regulation of immunoglobulin isotype switching. Adv. Immunol. 54, 229-270.
9. Corcoran, L.M., and Karvelas, M. (1994). Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation. Immunity 1, 635-645.
10. Corcoran, L.M., Karvelas, M., Nossal, G.J., Ye, Z.S., Jacks, T., and Baltimore, D. (1993). Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev. 7, 570-582.
11. Dariavach, P., Williams, G.T., Campbell, K., Pettersson, S., and Neuberger, M.S. (1991). The mouse IgH 3′-enhancer. Eur. J. Immunol. 21, 1499-1504.
12. Dearden-Badet, M.T., and Revillard, J.P. (1993). Requirement for tyrosine phosphorylation in lipopolysaccharide-induced murine B-cell proliferation. Immunology 80, 658-660.
13. Dreyfus, M., Doyen, N., and Rougeon, F. (1987). The conserved decanucleotide from the immunoglobulin heavy chain promoter induces a very high transcriptional activity in B-cells when introduced into an heterologous promoter. EMBO J. 6, 1685-1690.
14. Feldhaus, A.L., Klug, C.A., Arvin, K.L., and Singh, H. (1993). Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation. EMBO J. 12, 2763-2772.
15. Friedl, E.M., and Matthias, P. (1995). Transcriptional activation and repression, two properties of the lymphoid-specific transcription factor Oct-2a. Eur. J. Biochem. 234, 308-316.
16. Grant, P.A., Thompson, C.B., and Pettersson, S. (1995). IgM receptor-mediated transactivation of the IgH 3′ enhancer couples a novel Elf-1-AP-1 protein complex to the developmental control of enhancer function. EMBO J. 14, 4501-4513.
17. Grant, P.A., Andersson, T., Neurath, M.F., Arulampalam, V., Bauch, A., Muller, R., Reth, M., and Pettersson, S. (1996). A T cell controlled molecular pathway regulating the IgH locus: CD40-mediated activation of the IgH 3′ enhancer. EMBO J. 15, 6691-6700.
18. Gregor, P.D., and Morrison, S.L. (1986). Myeloma mutant with a novel 3′ flanking region: loss of normal sequence and insertion of repetitive elements leads to decreased transcription but normal processing of the α heavy chain gene products. Mol. Cell. Biol. 6, 1903-1916.
19. Grosschedl, R., and Baltimore, D. (1985). Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell 41, 885-897.
20. Gupta, S., Gollapudi, S., and Vayuvegula, B. (1988). Lipopolysaccharide-induced murine B cell proliferation: a role of protein kinase C. Cell. Immunol. 117, 425-429.
21. Herr, W., Sturm, R.A., Clerc, R.G., Corcoran, L.M., Baltimore, D., Sharp, P.A., Ingraham, H.A., Rosenfeld, M.G., Finney, M., and Ruvkun, G. (1988). The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev. 2, 1513-1516.
22. Humbert, P.O., and Corcoran, L.M. (1997). oct-2 gene disruption eliminates the peritoneal B-1 lymphocyte lineage and attenuates B-2 cell maturation and function. J. Immunol. 159, 5273-5284.
23. Jenuwein, T., and Grosschedl, R. (1991). Complex pattern of immunoglobulin μ gene expression in normal and transgenic mice: non-overlapping regulatory sequences govern distinct tissue specificity. Genes Dev. 5, 932-943.
24. Kearney, J.F., Cooper, M.D., and Lawton, A.R. (1976). B lymphocyte differentiation induced by lipopolysaccharide. III. Suppression of B cell maturation by anti-mouse immunoglobulin antibodies. J. Immunol. 116, 1664-1668.
25. Kearney, J.F., and Lawton, A.R. (1975). B lymphocyte differentiation induced by lipopolysaccharide. II. Response of fetal lymphocytes. J. Immunol. 115, 677-681.
26. Kim, U., Qin, X.F., Gong, S., Stevens, S., Luo, Y., Nussenzweig, M., and Roeder, R.G. (1996). The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes. Nature 383, 542-547.
27. Klemm, J.D., Rould, M.A., Aurora, R., Herr, W., and Pabo, C.O. (1994). Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. Cell 77, 21-32.
28. Laskov, R., Kim, J.K., Woods, V.L., McKeever, P.E., and Asofsky, R. (1981). Membrane immunoglobulins of spontaneous B lymphomas of aged BALB/c mice. Eur. J. Immunol. 11, 462-468.
29. Leitges, M., Schmedt, C., Guinamard, R., Davoust, J., Schaal, S., Stabel, S., and Tarakhovsky, A. (1996). Immunodeficiency in protein kinase c β-deficient mice. Science 273, 788-791.
30. Li, Y.S., Gimond, C., and Revillard, J.P. (1992). IL-5-induced IgA synthesis by LPS-stimulated mouse B cells is prevented by protein kinase C inhibitors. Eur. Cytokine Netw. 3, 103-107.
31. Lieberson, R., Giannini, S.L., Birshtein, B.K., and Eckhardt, L.A. (1991). An enhancer at the 3′ end of the mouse immunoglobulin heavy chain locus. Nucleic Acids Res. 19, 933-937.
32. Linderson, Y., Cross, D., Neurath, M.F., and Pettersson, S. (1997). NFE, a new transcriptional actiavtor that facilitates p50 and c-Rel-dependent IgH 3′ enhancer activity. Eur. J. Immunol. 27, 468-475.
33. Luo, Y., Fujii, H., Gerster, T., and Roeder, R.G. (1992). A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors. Cell 71, 231-241.
34. Madisen, L., and Groudine, M. (1994). Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. Genes Dev. 8, 2212-2226.
35. Madisen, L., Krumm, A., Hebbes, T.R., and Groudine, M. (1998). The immunoglobulin heavy chain locus control region increases histone acetylation along linked c-myc genes. Mol. Cell. Biol. 18, 6281-6292.
36. Manis, J.P., van der Stoep, N., Tian, M., Ferrini, R., Davidson, L., Bottaro, A., and Alt, F.W. (1998). Class switching in B cells lacking 3′ immunoglobulin heavy chain enhancers. J. Exp. Med. 188, 1421-1431.
37. Matthias, P. (1998). Lymphoid-specific transcription mediated by the conserved octamer site: who is doing what? Semin. Immunol. 10, 155-163.
38. Matthias, P., and Baltimore, D. (1993). The immunoglobulin heavy chain locus contains another B-cell-specific 3′ enhancer close to the α constant region. Mol. Cell. Biol. 13, 1547-1553.
39. Mey, A., and Revillard, J.P. (1998). Mitogenic response of murine B lymphocytes to Salmonella typhimurium LPS requires protein kinase C-dependent late tyrosine phosphorylations. Infect. Immun. 66, 2547-2552.
40. Michaelson, J.S., Giannini, S.L., and Birshtein, B.K. (1995). Identification of 3′ α-hs4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation. Nucleic Acids Res. 23, 975-981.
41. Michaelson, J.S., Singh, M., Snapper, C.M., Sha, W.C., Baltimore, D., and Birshtein, B.K. (1996). Regulation of 3′ enhancers by a common set of factors, including κ B-binding proteins. J. Immunol. 156, 2828-2839.
42. Natkunam, Y., Zhang, X., Liu, Z., and Chen, K.S. (1994). Simultaneous activation of Ig and Oct-2 synthesis and reduction of surface MHC class II expression by IL-6. J. Immunol. 153, 3476-3484.
43. Nielsen, P.J., Georgiev, O., Lorenz, B., and Schaffner, W. (1996). B lymphocytes are impaired in mice lacking the transcriptional co-activator Bob1/OCA-B/OBF1. Eur. J. Immunol. 26, 3214-3218.
44. Nishikawa, K., Toker, A., Johannes, F.J., Songyang, Z., and Cantley, L.C. (1997). Determination of the specific substrate sequence motifs of protein kinase C isozymes. J. Biol. Chem. 272, 952-960.
45. Ong, J., Stevens, S., Roeder, R.G., and Eckhardt, L.A. (1998). 3′ IgH enhancer elements shift synergistic interactions during B cell development. J. Immunol. 160, 4896-4903.
46. Pettersson, S., Cook, G.P., Bruggmann, M., Williams, G.T., and Neuberger, M.S. (1990). A second B cell-specific enhancer 3′ of the immunoglobulin heavy-chain locus. Nature 344, 165-168.
47. Pfisterer, P., Annweiler, A., Ullmer, C., Corcoran, L.M., and Wirth, T. (1994). Differential transactivation potential of Oct1 and Oct2 is determined by additional B cell-specific activities. EMBO J. 13, 1655-1663.
48. Pierani, A., Heguy, A., Fujii, H., and Roeder, R.G. (1990). Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters. Mol. Cell. Biol. 10, 6204-6215.
49. Pomerantz, J.L., and Sharp, P.A. (1994). Homeodomain determinants of major groove recognition. Biochemistry 33, 10851-10858.
50. Qin, X.F., Reichlin, A., Luo, Y., Roeder, R.G., and Nussenzweig, M.C. (1998). OCA-B integrates B cell antigen receptor-, CD40L-and IL 4-mediated signals for the germinal center pathway of B cell development. EMBO J. 17, 5066-5075.
51. Rush, J.S., and Waechter, C.J. (1987). Inhibitors of protein kinase C block activation of B lymphocytes by LPS. Biochem. Biophys. Res. Commun. 145, 1315-1320.
52. Saleque, S., Singh, M., and Birshtein, B.K. (1999). Ig heavy chain expression and class switching in vitro from an allele lacking the 3′ enhancers DNase l-hypersensitive hs3A and hs1,2. J. Immunol. 162, 2791-2803.
53. Scheidereit, C., Heguy, A., and Roeder, R.G. (1987). Identification and purification of a human lymphoid-specific octamer-binding protein (OTF-2) that activates transcription of an Ig promoter in vitro. Cell 51, 783-793.
54. Schreiber, E., Matthias, P., Muller, M.M., and Schaffner, W. (1989). Rapid detection of octamer binding proteins with "mini-extracts," prepared from a small number of cells. Nucleic Acids Res. 17, 6419.
55. Schubart, D.B., Rolink, A., Kosco, V.M., Botteri, F., and Matthias, P. (1996). B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. Nature 383, 538-542.
56. Segil, N., Roberts, S.B., and Heintz, N. (1991). Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. Science 254, 1814-1816.
57. Shah, P.C., Bertolino, E., and Singh, H. (1997). Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription. EMBO J. 16, 7105-7117.
58. Tanaka, M., Clouston, W.M., and Herr, W. (1994). The Oct-2 glutamine-rich and proline-rich activation domains can synergize with each other or duplicates of themselves to activate transcription. Mol. Cell. Biol. 14, 6046-6055.
59. Tanaka, M., and Herr, W. (1990). Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. Cell 60, 375-386.
60. Tang, H., Sun, X., Reinberg, D., and Ebright, R.H. (1996). Protein-protein interactions in eukaryotic transcription initiation: structure of the preinitiation complex. Proc. Natl. Acad. Sci. USA 93, 1119-1124.
61. Turner, C.A., Jr., Mack, D.H., and Davis, M.M. (1994). Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 77, 297-306.
62. van der Geer, P., and Hunter, T. (1994). Phosphopeptide mapping and phosphoamino acid analysis by electrophoresis and chromatography on thin-layer cellulose plates. Electrophoresis 15, 544-554.
63. Wirth, T., Staudt, L., and Baltimore, D. (1987). An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity. Nature 329, 174-177.
64. Xie, H., and Rothstein, T.L. (1995). Protein kinase C mediates activation of nuclear cAMP response element-binding protein (CREB) in B lymphocytes stimulated through surface Ig. J. Immunol. 154, 1717-1723.
65. Yuan, D., Wilder, J.A., Moore, B.B., and Dang, T. (1992). Mechanism of lipopolysaccharide-mediated transcriptional enhancement of the μ gene. J. Immunol. 48, 3652-3657.