Valproic acid for the treatment of pediatric malignant glioma

Klinische Padiatrie

Volumn 211, Issue 4, 1999, Pages 323-328

  Driever, Pablo Hernáiz ^a,d   Knupfer M M ^a   Cinatl, J ^b   Wolff, J E A ^c  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^c ALBERTA CHILDREN'S HOSPITAL   (Canada)

^d GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Consolidation therapy; Cytostasis; Differentiation induction; Malignant glioma; Valproic acid

Indexed keywords

VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSTASIS; GLIOBLASTOMA; HUMAN; HUMAN CELL; HYPOFIBRINOGENEMIA; IMMUNOGENICITY; NONHUMAN; PROGNOSIS; RAT; SKIN DISEASE; STEM CELL; THROMBOCYTOPENIA;

EID: 0032820525     PISSN: 03008630     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1043809     Document Type: Article

References (56)

1. 1 Aulthouse, A. L., D. C. Hitt: The teratogenic effects of valproic acid in human chondrogenesis in vitro. Teratology 49 (1994) 208-217
2. 2 Breslow, R., B. Jursic, Z. F. Yan, E. Friedman, L. Leng, L. Ngo, R. A. Rifkind, P. A. Marks: Potent cytodifferentiating agents related to hexamethylenebisacetamide. Proc. Natl. Acad. Sci. USA 88 (1991) 5542-5546
3. 3 Chen, G., H. K. Manji, D. B. Hawver, C. B. Wright, W. Z. Potter: Chronic sodium valproate selectively decreases protein kinase C alpha and epsilon in vitro. J. Neurochem. 63 (1994) 2361-2364
4. 4 Chen, G., P. Yuan, D. B. Hawver, W. Z. Potter, H. K. Manji: Increase in AP-1 transcription factor DNA binding activity by valproic acid. Neuropsychopharmacology 16 (1997) 238-245
5. 5 Chen, Z. X., T. R. Breitman: Tributyrin: a prodrug of butyric acid for potential clinical application in differentiation therapy. Cancer. Res. 54 (1994) 3494-3499
6. 6 Cheson, B. D., D. M. Jasperse, R. Simon, M. A. Friedman: A critical appraisal of low-dose cytosine arabinoside in patients with acute non-lymphocytic leukemia and myelodysplastic syndromes. J. Clin. Oncol. 4 (1986) 1857-1864
7. 7 Cinatl, J., Jr., J. Cinatl, P. H. Driever, R. Kotchetkov, P. Pouckova, B. Kornhuber, D. Schwabe: Sodium valproate inhibits in vivo growth of human neuroblastoma cells. Anticancer Drugs 8 (1997) 958-963
8. 8 Cinatl, J., Jr., J. Cinatl, M. Scholz, P. H. Driever, D. Henrich, H. Kabickova, J. U. Vogel, H. W. Doerr, B. Kornhuber: Antitumor activity of sodium valproate in cultures of human neuroblastoma cells. Anticancer Drugs 7 (1996) 766-773
9. 9 Cinatl, J., P. Herneiz, H. Rabenau, M. Hovak, R. Benda, H. O. Gumbel, B. Kornhuber, H. W. Doerr: Induction of myogenic differentiation in a human rhabdomyosarcoma cell line by phenylacetate. Cancer Lett. 78 (1994) 41-48
10. 10 Cinatl, J., M. Mainke, A. Weissflog, H. Rabenau, B. Kornhuber, H. W. Doerr: In vitro differentiation of human neuroblastoma cells induced by sodium phenylacetate. Cancer Lett. 70 (1993) 15-24
11. 11 Collins, A. F., G. J. Dover, N. L. Luban: Increased fetal hemoglobin production in patients receiving valproic acid for epilepsy [letter]. Blood 84 (1994) 1690-1691
12. 12 Edvardsen, K., W. Chen, G. Rucklidge, F. S. Walsh, B. Obrink, E. Bock: Transmembrane neural cell-adhesion molecule (NCAM), but not glycosyl-phosphatidylinositol-anchored NCAM, down-regulates secretion of matrix metalloproteinases. Proc. Natl. Acad. Sci. USA 90 (1993) 11463-11467
13. 13 Edvardsen, K., P. H. Pedersen, R. Bjerkvig, G. G. Hermann, J. Zeuthen, O. D. Laerum, F. S. Walsh, E. Bock: Transfection of glioma cells with the neural-cell adhesion molecule NCAM: effect on glioma-cell invasion and growth in vivo. Int. J. Cancer 58 (1994) 116-122
14. 14 Ehlers, K., H. Sturje, H. J. Merker, H. Nau: Spina bifida aperta induced by valproic acid and by all-trans-retinoic acid in the mouse: distinct differences in morphology and periods of sensitivity. Teratology 46 (1992) 117-130
15. 15 Engelhard, H. H., H. A. Duncan, M. Dal Canto: Molecular characterization of glioblastoma cell differentiation. Neurosurgery 41 (1997) 886-896; discussion 896-887
16. 16 Fenaux, P., M. C. Le Deley, S. Castaigne, E. Archimbaud, C. Chomienne, H. Link, A. Guerci, M. Duarte, M. T. Daniel, D. Bowen, et al.: Effect of all transretinoic acid in newly diagnosed acute promyelocytic leukemia. Results of a multicenter randomized trial. European APL 91 Group. Blood 82 (1993) 3241-3249
17. 17 Ge, L., N. M. Resnick, L. K. Ernst, L. A. Salvucci, D. C. Asman, D. L. Cooper: Gene therapeutic approaches to primary and metastatic brain tumors: II. ribozyme-mediated suppression of CD44 expression. J. Neurooncol. 26 (1995) 251-257
18. 18 Grunwald, S., P. H. Driever, D. Hoelzer, D. Drahovsky: Reduced methyl group acceptance of 1-beta-D-arabinofuranosylcytosine-containing DNA polymers. Biochim. Biophys. Acta 950 (1988) 366-373
19. 19 Knüpfer, M. M., P. Hernáiz Driever, H. Poppenborg, J. E. A. Wolff: Valproic acid inhibits proliferation and changes expression of CD44 and CD56 of malignant glioma cells in vitro. Anticancer Res in press (1998)
20. 20 Kokunai, T., A. Kawamura, N. Tamaki: Induction of differentiation by wild-type p53 gene in a human glioma cell line. J. Neurooncol. 32 (1997) 125-133
21. 21 Lenox, R. H., R. K. McNamara, J. M. Watterson, D. G. Watson: Myristoylated alanine-rich C kinase substrate (MARCKS): a molecular target for the therapeutic action of mood stabilizers in the brain? J. Clin. Psychiatry 57 (1996) 23-31; discussion 32-23
22. 22 Li, X. N., Z. W. Du, Q. Huang: Modulation effects of hexamethylene bisacetamide on growth and differentiation of cultured human malignant glioma cells. J. Neurosurg. 84 (1996) 831-838
23. 23 Liakopoulou, E., C. A. Blau, Q. Li, B. Josephson, J. A. Wolf, B. Fournarakis, V. Raisys, G. Dover, T. Papayannopoulou, G. Stamatoyannopoulous: Stimulation of fetal hemoglobin production by short fatty acids. Blood 86 (1995) 3227-3235
24. 24 Linskey, M. E., M. R. Gilbert: Glial differentiation: a review with implications for new directions in neuro-oncology. Neurosurgery 36 (1995) 1-21; discussion 21-22
25. 25 Liu, L., W. R. Hudgins, A. C. Miller, L. C. Chen, D. Samid: Transcriptional upregulation of TGF-alpha by phenylacetate and phenylbutyrate is associated with differentiation of human melanoma cells. Cytokine 7 (1995) 449-456
26. 26 Liu, L., W. R. Hudgins, S. Shack, M. Q. Yin, D. Samid: Cinnamic acid: a natural product with potential use in cancer intervention. Int. J. Cancer 62 (1995) 345-350
27. 27 Löscher, W.: Valproinsäure: Pharmakodynamische Wirkungen und biochemische Wirkungsmechanismen. In: Krämer, G., Laub, M. (Hrsg.): Valproinsäure. Springer-Verlag, Berlin, Heidelberg, New York (1992), pp. 3-23
28. 28 Martin, M. L., C. M. Regan: The anticonvulsant sodium valproate specifically induces the expression of a rat glial heat shock protein which is identified as the collagen type IV receptor. Brain Res 459 (1988) 131-137
29. 29 Martin, M. L., C. M. Regan: The anticonvulsant valproate teratogen restricts the glial cell cycle at a defined point in the mid-G1 phase. Brain Res. 554 (1991) 223-228
30. 30 McCarthy, D. M., J. F. San Miguel, H. C. Freake, P. M. Green, H. Zola, D. Catovsky, J. M. Goldman: 1,25-dihydroxyvitamin D3 inhibits proliferation of human promyelocytic leukaemia (HL60) cells and induces monocyte-macrophage differentiation in HL60 and normal human bone marrow cells. Leuk. Res. 7 (1983) 51-55
31. 31 Muller, W., D. Afra, R. Schroder: Supratentorial recurrences of gliomas. Morphological studies in relation to time intervals with astrocytomas. Acta Neurochir. 37 (1977) 75-91
32. 32 Nicolai, S., J. Willems, A. Zwijsen, E. Van Mechelen, H. Slegers: Cyclic AMP-induced differentiation increases the synthesis of extracellular superoxide dismutase in rat C6 glioma. Free Radic. Biol. Med. 21 (1996) 481-486
33. 33 Okada, H., J. Yoshida, M. Sokabe, T. Wakabayashi, M. Hagiwara: Suppression of CD44 expression decreases migration and invasion of human glioma cells. Int. J. Cancer 66 (1996) 255-260
34. 34 Prasanna, P., A. Thibault, L. Liu, D. Samid: Lipid metabolism as a target for brain cancer therapy: synergistic activity of lovastatin and sodium phenylacetate against human glioma cells. J. Neurochem. 66 (1996) 710-716
35. 35 Ram, Z., D. Santid, S. Walbridge, E. M. Oshiro, J. J. Viola, J. H. Tao-Cheng, S. Shack, A. Thibault, C. E. Myers, E. H. Oldfield: Growth inhibition, tumor maturation, and extended survival in experimental brain tumors in rats treated with phenylacetate. Cancer Res. 54 (1994) 2923-2927
36. 36 Regan, C. M.: Therapeutic levels of sodium valproate inhibit mitotic indices in cells of neural origin. Brain Res. 347 (1985) 394-398
37. 37 Reuben, R. C., P. L. Khanna, Y. Gazitt, R. Breslow, R. A. Rifkind, P. A. Marks: Inducers of erythroleukemic differentiation. Relationship of structure to activity among planar-polar compounds. J. Biol. Chem. 253 (1978) 4214-4218
38. 38 Rogiers, V., M. Akrawi, A. Vercruysse, I. R. Phillips, E. A. Shephard: Effects of the anticonvulsant, valproate, on the expression of components of the cytochrome-P-450-mediated monooxygenase system and glutathione S-transferases. Eur. J. Biochem. 231 (1995) 337-343
39. 39 Sakai, H., S. Nakashima, S. Yoshimura, K. Nakatani, J. Shinoda, N. Sakai, H. Yamada, Y. Nozawa: Suppressed expression of CD44 variant isoforms during human glioma A172 cell differentiation induced by cyclic AMP. Neurosci. Lett. 210 (1996) 189-192
40. 40 Samid, D., W. R. Hudgins, S. Shack, L. Liu, P. Prasanna, C. E. Myers: Phenylacetate and phenylbutyrate as novel, nontoxic differentiation inducers. Adv. Exp. Med. Biol. (1997) 501-505
41. 41 Segovia, J., G. M. Lawless, N. J. Tillakarame, M. Brenner, A. J. Tobin: Cyclic AMP decreases the expression of a neuronal marker (GAD67) and increases the expression of an astroglial marker (GFAP) in C6 cells. J. Neurochem. 63 (1994) 1218-1225
42. 42 Selby, R., E. Nisbet-Brown, R. K. Basran, L. Chang, N. F. Olivieri: Valproic acid and augmentation of fetal hemoglobin in individuals with and without sickle cell disease [letter]. Blood 90 (1997) 891-893
43. 43 Skladchikova, G., V. Berezin, E. Bock: Valproic acid, but not its non-teratogenic analogue 2-isopropylpentanoic acid, affects proliferation, viability and neuronal differentiation of the human teratocarcinoma cell line NTera-2. Neurotoxicology 19 (1998) 357-370
44. 44 Slesinger, P. A., H. S. Singer: Effects of anticonvulsants on cell growth and enzymatic and receptor binding activity in a neuroblastoma x glioma hybrid cell culture. Epilepsia 28 (1987) 214-221
45. 45 Smith, M. A., D. R. Parkinson, B. D. Cheson, M. A. Friedman: Retinoids in cancer therapy. J. Clin. Oncol. 10 (1992) 839-864
46. 46 Soffietti, R., A. Chio, M. T. Giordana, E. Vasario, D. Schiffer: Prognostic factors in well-differentiated cerebral astrocytomas in the adult [see comments]. Neurosurgery 24 (1989) 686-692
47. 1N′ -bis(2-chloroethyl)-N-nitrosourea] by simvastatin. Cancer Res. 55 (1995) 597-602
48. 48 Suda, T., T. Shinki, N. Takahashi: The role of vitamin D in bone and intestinal cell differentiation. Annu. Rev. Nutr. 10 (1990) 195-211
49. 49 Thibault, A., M. R. Cooper, W. D. Figg, D. J. Venzon, A. O. Sartor, A. C. Tompkins, M. S. Weinberger, D. J. Headlee, N. A. McCall, D. Samid, et al.: A phase I and pharmacokinetic study of intravenous phenylacetate in patients with cancer. Cancer Res. 54 (1994) 1690-1694
50. 50 Thibault, A., D. Samid, M. R. Cooper, W. D. Figg, A. C. Tompkins, N. Patronas, D. J. Headlee, D. R. Kohler, D. J. Venzon, C. E. Myers: Phase I study of phenylacetate administered twice daily to patients with cancer. Cancer 75 (1995) 2932-2938
51. 51 Tittle, T. V., B. A. Schaumann: Effect of antiepileptic drugs on growth of murine lymphoid tumor cells in single-cell culture. Epilepsia 33 (1992) 729-735
52. 52 Unkelbach, S.: Pankreas-spezifische Nebenwirkungen unter Valproinsäure. In: Krämer, G., Laub, M. (Hrsg.): Valproinsäure. Springer-Verlag, Berlin, Heidelberg, New York (1992), pp. 241-251
53. 53 Velazquez, O. C., J. L. Rombeau: Butyrate. Potential role in colon cancer prevention and treatment. Adv. Exp. Med. Biol. 427 (1997) 169-181
54. 54 Vertosick, F. T., Jr., R. G. Selker, V. C. Arena: Survival of patients with well-differentiated astrocytomas diagnosed in the era of computed tomography. Neurosurgery 28 (1991) 496-501
55. 55 Yoshimura, S., S. Nakashima, K. Ohguchi, H. Sakai, J. Shinoda, N. Sakai, Y. Nozawa: Differential mRNA expression of phospholipase D (PLD) isozymes during cAMP-induced differentiation in C6 glioma cells. Biochem. Biophys. Res. Commun. 225 (1996) 494-499
56. 56 Young, L. T., C. M. Woods: Mood stabilizers have differential effects on endogenous ADP ribosylation in C6 glioma cells. Eur. J. Pharmacol. 309 (1996) 215-218