Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold

Journal of Medicinal Chemistry

Volumn 44, Issue 20, 2001, Pages 3231-3243

  Schroder J ^a   Henke, A ^a   Wenzel, H ^a   Brandstetter, H ^b   Stammler, H G ^a   Stammler, A ^a   Pfeiffer, W D ^c   Tschesche, H ^a  

^a BIELEFELD UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,3,4 THIADIAZINE DERIVATIVE; MATRIX METALLOPROTEINASE INHIBITOR;

ARTHRITIS; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; KINETICS; MODELS, MOLECULAR; PROTEASE INHIBITORS; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIADIAZINES;

EID: 0035959994     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010887p     Document Type: Article

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