Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF- α production

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 9, 1999, Pages 1279-1284

  Cherney, Robert J ^a   Wang, Li ^a   Meyer, Dayton T ^a   Chu Biao, Xue ^a   Arner, Elizabeth C ^a   Copeland, Robert A ^b   Covington, Maryanne B ^a   Hardman, Karl D ^b   Wasserman, Zelda R ^a   Jaffee, Bruce D ^b   Decicco, Carl P ^a  

^a DUPONT COMPANY   (United States)

^b Building 400 3255   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE; SUCCINIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BINDING AFFINITY; CYCLIZATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

COLLAGENASES; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; KINETICS; LIPOPOLYSACCHARIDES; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MODELS, CHEMICAL; MODELS, MOLECULAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033519308     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00178-X     Document Type: Article

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