Discovery of potent, achiral matrix metalloproteinase inhibitors [4]

Journal of Medicinal Chemistry

Volumn 41, Issue 19, 1998, Pages 3568-3571

  Pikul, S ^a   Dunham, K L M ^a   Almstead, N G ^a   De, B ^a   Natchus, M G ^a   Anastasio, M V ^a   McPhail, S J ^a   Snider, C E ^a   Taiwo, Y O ^a   Rydel, T ^a   Dunaway, C M ^a   Gu, F ^a   Mieling, G E ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BATIMASTAT; CGS 27023A; CIPEMASTAT; ILOMASTAT; MARIMASTAT; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; N1 [2,2 DIMETHYL 1 [(METHYLAMINO)CARBONYL]PROPYL] N4 HYDROXY 2 (2 METHYLPROPYL)BUTANEDIAMIDE; PRINOMASTAT; UNCLASSIFIED DRUG;

CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; LETTER;

COLLAGENASES; CRYSTALLOGRAPHY, X-RAY; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 7; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPERAZINES; PROTEASE INHIBITORS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032505173     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980253r     Document Type: Letter

References (21)