Bombesin may stimulate proliferation of human pancreatic cancer cells through an autocrine pathway

International Journal of Cancer

Volumn 68, Issue 4, 1996, Pages 528-534

  Wang, Qiming J ^a   Knezetic, Joseph A ^a   Schally, Andrew V ^b   Pour, Parviz M ^c   Adrian, Thomas E ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOMBESIN; GROWTH FACTOR;

ARTICLE; AUTOCRINE EFFECT; CONTROLLED STUDY; GROWTH STIMULATION; HUMAN; HUMAN CELL; PANCREAS CARCINOMA; PRIORITY JOURNAL; TUMOR CELL LINE;

EID: 0029808418     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0215(19961115)68:4<528::aid-ijc20>3.0.co;2-%23     Document Type: Article

References (26)

1. ALEXANDER, R.W., UPP, J.R., POSTON, G.J., TOWNSEND, C.M., SINGH, P. and THOMPSON, J.C., Bombesin inhibits growth of human pancreatic adenocarcinoma in nude mice. Pancreas, 3, 297-302 (1988).
2. AVIS, F.P., MANECKJEE, R., CUTTITTA, F., NAKANISHI, Y., MULSHINE, J. and AVIS, I., The role of gastrin releasing peptide in a pancreatic tumor cell line (CAPAN). Proc. Amer. Ass. Cancer Res., 29, 54-59 (1988).
3. BUNNETT, N.W., KOBAYASHl, R., ORLOFF, M.S., REEVE, J.R., TURNER, A.J. and WALSH, J.H., Catabolism of gastrin releasing peptide and substance P by gastric membrane-bound peptides. Peptides. 6, 277-283 (1985).
4. CORJAY, M.H., DOBRANSKl, D.J., WAY, J.M., VIALLET, J., SHAPIRA, H., WORLAND, P., SAUSVILEE, E.A. and BATTEY, J.F., Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. J. biol. Chem., 266, 18771-18779 (1991).
5. CUTTITTA, F., CARNEY, N., MULSHINE, J., MOODY, T.W., FEDORKO, J., FISCHLER, A. and MINNA, J.D., Bombesin-like peptides can function as autocrine growth factors in human small cell lung cancer. Nature (Lond.), 318, 823-826 (1985).
6. GHATEI, M.A., Bombesin. In: S.R. Bloom and R.G. Long (eds.), Radioimmunoassay of gut regulatory peptides, pp. 131-137, W.B. Saunders, London (1982).
7. HAJRI, A., BALBONI, G., KOENIG, M., GARAUD, J.C. and DAMGE, C., Gastrin-releasing peptide: in vivo and in vitro growth effects on an acinar pancreatic carcinoma. Cancer Res., 52, 3726-3732 (1991).
8. LHOSTE, E.F., APRAHAMIAN, M., BALBONI, G. and DAMGE, C., Evidence for a direct trophic effect of bombesin on the mouse pancreas: in vivo and cell culture studies. Regul. Peptides, 24, 45-54 (1989).
9. LIEHR, R.M., MELNYKOVYCH, G. and SOLOMON, T.E., Growth effects of regulatory peptides on human pancreatic cancer cell lines PANC-1 and MIA PaCa-2. Gastroenterology, 98, 1666-1674 (1990).
10. MANGINO, M.M., HUBCHAK, S. and SCARPELLI, D.G., Stimulation of DNA synthesis in pancreatic duct cells by gastrointestinal hormones: interaction with other growth factors. Pancreas, 7, 271-279 (1992).
11. MILLER, J.B. and ROZENGURT, E., Chronic desensitization to bombesin by progressive down-regulation of bombesin receptors in Swiss 3T3 cells. J. biol. Chem., 265, 12052-12058 (1990).
12. MOODY, T.W., PERT, C.B., GAZDAR, A.F., CARNEY, D.M. and MINA, J.D., High levels of intracellular bombesin characterize human small cell lung carcinoma. Science, 214, 1246-1248 (1981).
13. MOSMANN, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63 (1983).
14. QIN, Y., ERTL, T., CAI, R.-Z., HALMOS, G. and SCHALLY, A.V., Inhibitory effect of bombesin receptor antagonist RC-3095 on the growth of human pancreatic cancer cells in vivo and in vitro. Cancer Res., 54, 1035-1041 (1994).
15. RADULOVIC, S., COMARU-SCHALLY, A.M., MILOVANOVIC, S. and SCHALLY, A.V., Somatostatin analogue RC-160 and LH-RH antagonist SB-75 inhibit growth of MIA PaCa-2 human pancreatic cancer xenografts in nude mice. Pancreas, 8, 88-97 (1991).
16. SINGH, P., DRAVIAM, E., GUO, Y.S. and KUROSKY, A., Molecular characterization of bombesin receptors on rat pancreatic acinar AR42J cells. Amer. J. Physiol., 258, G803-G809 (1990).
17. SPINDEL, E.R., CHIN, W.W., PRICE, J., REES, L.H., BESSER, G.M. and HABENER, J.F., Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleolides. Proc. nat. Acad. Sci. (Wash.), 83, 19-23 (1986).
18. SUNDAY, M.E., KAPLAN, L.M., MOTOYAMA, E., CHIN, W.W. and SPINDEL, E.R., Gastrin-releasing peptide (mammalian bombesin) gene expression in health and disease. Lab. Invest., 59, 5-24 (1988).
19. SZEPESHAZI, K., SCHALLY, A.V., CAI, R.Z., RADULOVIC, S., MILOVANOVIC, S. and SZOKE, B., Inhibitory effect of bombesin/gastrin-releasing peptide antagonist RC-3095 and high dose of somatostatin analogue RC-160 on nitrosamine-induced pancreatic cancers in hamsters. Cancer Res., 51, 5980-5986 (1991).
20. THOMPSON, J.C. and MARX, M., Gastrointestinal hormones. In: M.M. Ravitch and F.M. Steichen (eds.), Current problems in surgery, vol. 21, pp. 1-80, Year Book Medical Publisher, Chicago (1984).
21. UPP, L.R., MACLELLAN, D.G., POSTON, G.J., TOWNSEND, C.M., JR. and THOMPSON, J.C., Mechanism of trophic actions of bombesin on the pancreas. Pancreas, 3, 193-198 (1988).
22. WANG, L.H., MANTEY, S.A., LIN, J.T., FRUCHT, H. and JENSEN, R.T., Ligand binding, internalization, degradation and regulation by guanine nucleotides of bombesin receptor subtypes: a comparative study. Biochim. Biophys. Acta, 1175, 232-242 (1993).
23. WEBER, S., ZUCKERMAN, J.E., BOSTWICK, D.G., BENSCH, K.G., SIKIC, B.I. and RAFFIN, T., Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro. J. clin. Invest., 75, 306-309 (1985).
24. YANO, T., PINSKI, J., GROOT, K. and SCHALLY, A.V., Stimulation by bombesin and inhibition bybombesin/gastrin releasing peptide antagonist RC-3095 of growth of human breast cancer cell lines. Cancer Res., 52, 4545-4547 (1992).
25. ZACHARY, L. and ROZENGURT, E., High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells. Proc. nat. Acad. Sci. (Wash.), 82, 7616-7622 (1985).
26. ZHU, W.Y., GOKE, B. and WILLIAMS, J.A., Binding, internalization and processing of bombesin by rat pancreatic acini. Amer. J. Physiol., 261, G57-G64 (1991).