The common I172N mutation causes conformational change of cytochrome P450c21 revealed by systematic mutation, kinetic, and structural studies

Journal of Biological Chemistry

Volumn 271, Issue 6, 1996, Pages 3306-3310

  Hsu, Li Chung ^a   Hsu, Nai Chi ^a   Guzova, Julia A ^a   Guzov, Victor M ^a,c,d   Chang, Shwu Fen ^a,b   Chung, Bon Chu ^a  

^a INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c INSTITUTE FOR MATHEMATICS   (Belarus)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450; HYDROXYPROGESTERONE; PROGESTERONE; STEROID 21 MONOOXYGENASE;

AMINO ACID SUBSTITUTION; ARTICLE; CELLULAR DISTRIBUTION; ENDOPLASMIC RETICULUM; ENZYME KINETICS; ENZYME STRUCTURE; GENE EXPRESSION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROGESTERONE METABOLISM; PROTEIN LOCALIZATION; SITE DIRECTED MUTAGENESIS; YEAST;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; CONSERVED SEQUENCE; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; ISOLEUCINE; KINETICS; MICE; MICROSOMES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN CONFORMATION; RATS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; STEROID 21-HYDROXYLASE;

EID: 0030020703     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.6.3306     Document Type: Article

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