Sexual dimorphism of hypertension

Current Opinion in Nephrology and Hypertension

Volumn 5, Issue 2, 1996, Pages 181-185

  Chen, Yiu Fai ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEX HORMONE;

ANIMAL MODEL; BLOOD PRESSURE REGULATION; GENETICS; HUMAN; HYPERTENSION; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SEX DIFFERENCE; VASCULAR DISEASE;

ANIMALS; BLOOD PRESSURE; FEMALE; HUMANS; HYPERTENSION; MALE; SEX CHARACTERISTICS;

EID: 0029896586     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199603000-00015     Document Type: Review

References (33)

1. Stamler J, Stamler R, Riedlinger WF, Algera G, Roberts RH: Hypertension screening of 1 million Americans. Community Hypertension Evaluation Clinic (CHEC) program, 1973-1975. JAMA 1976, 235:2299-2306.
2. Hypertension Detection and Follow-up Program Cooperative Group. Blood pressure studies in 14 communities: a two-stage screen for hypertension. JAMA 1977, 237:2385-2391.
3. Cornoni-Huntley J, LaCroix AZ, Havlik RJ: Race and sex differentials in the impact of hypertension in the United States. The National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. Arch Intern Med 1989, 149:780-788.
4. Rowland M, Roberts J: Blood pressure levels and hypertension in persons aged 6-74 years: United States, 1976-80. NCHS Advance Data from Vital and Health Statistics of the National Center of Health Statistics 84. Washington D.C: USA Government Publication; 1982.
5. Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, Horan MJ, Labarthe D: Prevalence of Hypertension in the US adult population: results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension 1995, 25:305-313. Data from phase 1 of the Third National Health and Nutrition Examination Survey (NHANES III), collected from 9901 participants aged 18 years and older from 1988-1991, indicate that 24% or an estimated 43 million of the adult population of the USA had hypertension. In all age and racial groups surveyed, men had average SBP and DBP that were 6-7 and 3-5 mmHg higher, respectively, than the average values in women. Men started to have hypertension from early adulthood; however, the rise of blood pressure with age was steeper for women than for men. As a result, average SBP for women was as high as or higher than the corresponding value for men during and after the seventh decade. Theee data indicate a sexually dimorphic pattern of hypertension in the human population.
6. Vokonas PS, Kannel WB, Cupples LA: Epidemiology and risk of hypertension in the elderly: the Framingham Study. J Hypertens 1988, 6(supple 1):3-9.
7. Hjortland MC, McNamara PM, Kannel WB: Some atherogenic concomitants of menopause: the Framingham Study. Am J Epidemiol 1976, 103:304-311.
8. Matthews KA, Meilahn E, Kuller LH: Menopause and risk factors for coronary heart disease. N Engl J Med 1989, 321:641-646.
9. Van Berensteyn ECH, Van 'T Hof MA, De Waard H: Contributions of ovarian failure and aging to blood pressure in normotensive perimenopausal women: a mixed longitudinal study. Am J Epidemiol 1989, 129:947-955.
10. Staessen J, Bulpitt CJ, Fagard R, Lijnen P, Amery A: The influence of menopause on blood pressure. J Hum Hypertens 1989, 3:427-433.
11. Schlager G: Genetic and physiological studies of blood pressure in mice. I. Crosses between A/J. SWR/J, and their hybrids. Can J Genet Cytol 1968, 10:833-864.
12. Dahl LK, Knudsen KD, Ohanian EV, Muirhead M, Tuthill R: Role of the gonads in hypertension-prone rats. J Exp Med 1975, 142:748-759.
13. Iam SG, Wexler BC: Inhibition of the development of spontaneous hypertension in SH rats by gonadectomy or estradiol. J Lab Clin Med 1979, 94:608-616.
14. Cambotti LJ, Cole FE, Gerall AA, Frohlich ED, MacPhee AA: Neonatal gonadal hormones and blood pressure in the spontaneously hypertensive rat. Am J Physiol 1986, 247:E258-E264.
15. Ouchi Y, Share L, Crofton JT, Iitake K, Brooks DP: Sex difference in the development of deoxycorticosterone-salt hypertension in the rat. Hypertension 1987, 9:172-177.
16. Ganten U, Schroder G, Witt M, Zimmermann F, Ganten D, Stock G: Sexual dimorphism of blood pressure in spontaneously hypertensive rats: effects of anti-androgen treatment. J Hypertens 1989, 7:721-726.
17. Chen YF, Meng QC: Sexual dimorphism of blood pressure in spontaneously hypertensive rats is androgen dependent. Life Sci 1991, 48:85-96.
18. Masubuchi Y, Kumai T, Uematsu A, Komoriyama K, Hirai M: Gonadectomy-induced reduction of blood pressure in adult spontaneously hypertensive rats. Acta Endocrinol (Copenh) 1982, 101:154-160.
19. Crofton JT, Share L, Brooks DP: Gonadectomy abolishes the sexual dimorphism in DOC-salt hypertension in the rat. Clin Exp Hypertens [A] 1989, 11:1249-1261.
20. 2-adrenergic receptor density in the spontaneously hypertensive rat. Hypertension 1994, 23:607-612.
21. 2B-adrenergic receptor mRNA levels. Hypertension 1995, 25:350-355.
22. Harrap SB, Wang BZ, MacLellan DG: Renal transplantation between male and female spontaneously hypertensive rats. Hypertension 1992, 19:431-434.
23. Lee MA, Bohm M, Paul M, Ganten D: Tissue renin-angiotensin systems. Their role in cardiovascular disease. Circulation 1993, 87(suppl V):IV7-IV13.
24. Nielsen AH, Johannessen A, Poulsen K: Inactive plasma renin exhibits sex difference in mice. Clin Sci 1989, 76:439-446.
25. Johannessen A, Nielsen AH, Poulsen K: Sexual dimorphism of inactive renin in rat plasma. Clin Exp Hypertens [A] 1990, 12:1405-1417.
26. Chen YF, Naftilan AJ, Oparil S: Androgen-dependent angiotensinogen and messenger RNA expression in hypertensive rats. Hypertension 1992, 19:456-463.
27. Sealey JE, Atlas SA, Laragh JH: Prorenin and other large molecular weight forms of renin. Endocr Rev 1980, 1:365-391.
28. Wagner D, Metzger R, Paul M, Ludwig G, Suzuki F, Takahashi S, Murakami K, Ganten D: Androgen dependent and tissue specificity of renin messenger RNA expression in mice. J Hypertens 1990, 8:45-52.
29. Ellison KE, Ingelfinger JR, Pivor M, Dzau VJ: Androgen regulation of rat renal angiotensinogen messenger RNA expression. J Clin Invest 1989, 83:1941-1945.
30. Mullins JJ, Peters J, Ganten D: Fulminant hypertension in transgenic rat harboring the mouse Ren 2 gene. Nature 1990, 344:541-544.
31. Bachmann J, Feldmer M, Ganten U, Stock G, Ganten D: Sexual dimorphism of blood pressure: possible role of the renin-angiotensin system. J Steroid Biochem Mol Biol 1991, 40:511-515.
32. Krege JH, John SWM, Langenbach LL, Hodgin JB, Hagaman JR, Bachman ES, Jennette JC, O'Brien DA, Smithies O: Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 1995, 375:146-148. The authors have generated a strain of mice that carries an insertional mutation that inactivates ACE. Male mice having a single copy of the ACE gene have blood pressure significantly lower than males having two copies of the gene, whereas females having one and two copies of the gene appear to have identical blood pressures. This suggests that genetic variation in the somatic ACE gene may account for the sexual dimorphism of blood pressure in the mouse.
33. Calhoun DA, Zhu ST, Chen YF, Oparil S: Gender and dietary NaCl in spontaneously hypertensive and Wistar-Kyoto rats. Hypertension 1995, 26:285-289. The authors used a telemetry monitoring system to evaluate the effects of high dietary NaCl exposure on diurnal variation of blood pressure in male and female SHR and WKY rats. Two-week high dietary NaCl (8%) ingestion significantly increased both day-time and night-time mean arterial pressure in male SHR, and increased night-time mean arterial pressure in male WKY. High dietary NaCl did not increase either day-time or night-time mean arterial pressure in female rats of either strain. These results indicate a sexually dimorphic response to dietary NaCl ingestion.