Mitochondrial transmembrane potential and free radical production in excitotoxic neurodegeneration

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 357, Issue 3, 1998, Pages 316-322

  Prehn, Jochen H M ^a,b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Cell death; Digital videomicroscopy; Glutamate; Hydroethidine; Rat hippocampal neurons; Rhodamine 123; Superoxide

Indexed keywords

EXCITOTOXIN; FREE RADICAL; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; RHODAMINE 123; SUPEROXIDE;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; HIPPOCAMPUS; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; RAT; VIDEORECORDING;

ANIMALS; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; KAINIC ACID; MEMBRANE POTENTIALS; MITOCHONDRIA; N-METHYLASPARTATE; NEURONS; RATS; RATS, INBRED F344; SUPEROXIDES;

EID: 0031891837     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005173     Document Type: Article

References (45)

1. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15: 961-973
2. Ankarcrona M, Dypbukt JM, Orrenius S, Nicotera P (1996) Calcineurin and mitochondrial function in glutamate-induced neuronal cell death. FEBS Lett 394: 321-324
3. Bindokas VP, Miller RJ (1995) Excitotoxic degeneration is initialed at non-random sites in cultured rat cerebellar neurons. J Neurosci 15: 6999-7011
4. Bindokas VP, Jordan J, Lee CC, Miller RJ (1996) Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J Neurosci 16: 1324-1336
5. 2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells. J Neurosci 15: 187-197
6. Brorson JR, Manzolillo PA, Gibbons SJ, Miller RJ (1995) AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity. J Neurosci 15: 4515-4524
7. Bucana C, Saiki I, Nayar R (1986) Uptake and accumulation of the vital dye hydroethidine in neoplastic cells. J Histochem Cytochem 34: 1109-1155
8. Budd SL, Nicholls DG (1996) Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells. J Neurochem 67: 2282-2291
9. 2+: an alternate mechanism for the cardiotoxicity of doxirubicin. Toxicol Appl Pharmacol 107: 117-128
10. Choi DW (1985) Glutamate neurotoxicity in cortical cell culture is calcium dependent. Neurosci Lett 58: 293-297
11. Choi DW, Koh JY, Peters S (1988) Pharmacology of glutamate neurotoxicity in cortical cell cultures. J Neurosci 8: 185-196
12. Dubinsky JM, Rothman SM (1991) Intracellular calcium concentration during "chemical hypoxia" and excitotoxic neuronal injury. J Neurosci 11 : 2545-2551
13. 2+ dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons. Biochem J 283:41-50
14. Dugan LL, Sensi SL, Canzoniero LMT, Handran SD, Rothman SM. Lin T-S, Goldberg MP, Choi DW (1995) Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. J Neurosci 15:6377-6388
15. +: implications for neurodegeneration. J Neurochem 63: 584-591
16. Ehrenberg B, Montana V, Wie MD, Wuskell JP. Loew LM (1988) Membrane potential can be determined in individual cells from the nernstian distribution of cationic dyes. Biophys J 53: 785-794
17. Emaus RK, Grunwald R, Lemasters JJ (1986) Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochem Biophys Acta 850: 436-448
18. Garthwaite G, Garthwaite J (1986) Neurotoxicity of excitatory amino acid agonists in rat cerebellar slices: dependence on calcium concentration. Neurosci Lett 66: 193-198
19. 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J Neurosci 13: 1993-2000
20. Hyrc K, Handran SD, Rothman SM, Goldberg MP (1997) Ionized intracellular calcium concentration predicts excitotoxic neuronal death: observations with low-affinity fluorescent calcium indicators. J Neurosci 17: 6669-6677
21. Kinouchi H, Epstein CJ, Mizui T, Carlson E, Chen SF, Chan PH (1991) Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn-superoxide dismutase. Proc Natl Acad Sci USA 88: 11158-11162
22. Koh J-Y, Goldberg MP, Hartley DM, Choi DW (1990) Non-NMDA receptor-mediated neurotoxicity in cortical culture. J Neurosci 10: 693-705
23. Krieglstein J (1989) Excitatory amino acids, adenosine and neuronal calcium homeostasis - an overview. In: Seylaz J, Sercombe R (eds) Neurotransmission and cerebrovascular function II. Elsevier, Amsterdam, pp 441-453
24. Lafon-Cazal M, Pietri S, Culcasi M, Bockaert J (1993) NMDA-dependent Superoxide production and neurotoxicity. Nature 364: 535-537
25. 2+ influx underlies potent induction of injury. J Neurosci 16: 5457-5465
26. Malis CD, Bonventre JV (1985) Mechanism for calcium potentiation of oxygen free radical injury to renal mitochondria. J Biol Chem 261: 14201-14208
27. McCormack JG, Halestrap AP, Denton RM (1990) Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol Rev 70: 391-425
28. Michaels RL, Rothman SM (1990) Glutamate neurotoxicity in vitro, antagonist pharmacology and intracellular calcium concentrations. J Neurosci 10: 283-292
29. Monyer H. Hartley DM, Choi DW (1990) 21-Aminosteroids attenuate excitotoxic neuronal injury in conical cell culture. Neuron 5: 121-126
30. 2a homeostasis in hippocampal neurons in vitro. Mol Pharmacol 35: 671-680
31. Nicholls D, Åkerman K (1982) Mitochondrial calcium transport. Biochim Biophys Acta 683: 57-88
32. Partin KM, Patneau DK, Winters CA, Mayer ML, Buonanno A (1993) Selective modulation of densensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron 11: 1069-1082
33. Patel M, Day BJ, Crapo JD, Fridovich I, McNamara JO (1996) Requirement for superoxide in excitotoxic cell death. Neuron 16: 345-355
34. Prehn JHM, Karkoutly C, Nuglisch J, Peruche B, Krieglstein J (1992) Dihydrolipoate reduces neuronal injury after cerebral ischemia. J Cereb Blood Flow Metab 12: 78-87
35. Prehn JHM. Bindokas VP, Marcuccilli CJ, Krajewski S, Reed JC, Miller RJ (1994) Regulation of neuronal Bc12 protein expression and calcium homeostasis by transforming growth factor type β confers wide-ranging protection on rat hippocampal neurons. Proc Natl Acad Sci USA 91: 12599-12603
36. Prehn JHM, Bindokas VP, Jordan J, Galindo MF, Ghadge GD, Roos RP, Boise LH, Thompson CB, Krajewski S, Reed JC, Miller RJ (1996) Protective effect of transforming growth factor-β1 on β-amyloid neurotoxicity in rat hippocampal neurons. Mol Pharmacol 49: 319-328
37. Randall RD, Thayer SA (1992) Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons. J Neurosci 12: 1882-1895
38. Reynolds IJ, Hastings TG (1995) Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J Neurosci 15: 3318-3327
39. Rothe G, Valet G (1990) Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2′,7′-dichlorofluorescin. J Leukocyte Biol 47: 440-448
40. 2+ concentration. Eur J Pharmacol 294: 469-473
41. Schinder AF, Olson EC, Spitzer NC, Montal M (1996) Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J Neurosci 16: 6125-6133
42. Seeburg PH (1993) The TiPS/TiNS lecture: the molecular biology of mammalian glutamate receptor channels. Trends Pharmacol Sci 14:297-303
43. Tymianski MT, Charlton MP, Carlen PL, Tator TH (1993) Source specifity of early calcium neurotoxicity in cultured embryonic spinal neurons. J Neurosci 13: 2085-2104
44. While RJ, Reynolds IJ (1996) Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure. J Neurosci 16: 5688-5697
45. Zorumski CF, Thio LL, Clark GD. Clifford DB (1990) Blockade of desensitization augments quisqualate excitotoxicity in hippocampal neurons. Neuron 5: 61-66