A chicken gonadotropin-releasing hormone receptor that confers agonist activity to mammalian antagonists. Identification of D-LYS6 in the ligand and extracellular loop two of the receptor as determinants

Journal of Biological Chemistry

Volumn 276, Issue 11, 2001, Pages 7754-7761

  Sun, Yuh Man ^a,c   Flanagan, Colleen A ^a   Illing, Nicola ^a   Ott, Thomas R ^a,b   Sellar, Robin ^b   Fromme, Bernhard J ^a   Hapgood, Janet ^a,e   Sharp, Peter ^c   Sealfon, Stuart C ^d   Millar, Robert P ^a,b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b MRC Reproductive Biology Unit   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CLONING; DNA SEQUENCES;

EXTRACELLULAR DOMAINS; HUMAN RECEPTORS; MAMMALIAN ANTAGONISTS;

HORMONES;

DEXTRO LYSINE; GONADORELIN RECEPTOR; HISTIDINE; TRYPTOPHAN; TYROSINE; LYSINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHICKEN; HYPOPHYSIS; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BLOCKING; RECEPTOR INTRINSIC ACTIVITY; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; ANIMAL; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG POTENTIATION; MOLECULAR GENETICS; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ANIMALIA; GALLUS GALLUS; MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CHICKENS; CLONING, MOLECULAR; LYSINE; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTORS, LHRH; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035896512     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009020200     Document Type: Article

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