The D136A mutation of the V2 vasopressin receptor induces a constitutive activity which permits discrimination between antagonists with partial agonist and inverse agonist activities

FEBS Letters

Volumn 441, Issue 3, 1998, Pages 470-475

  Morin, Denis ^a,b   Cotte, Nathalie ^a   Balestre, Marie Noëlle ^a   Mouillac, Bernard ^a   Manning, Maurice ^c   Breton, Christophe ^a   Barberis, Claude ^a  

^a CCIPE   (France)

^b Service de Pédiatrie I   (France)

^c MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Constitutively active mutant V2 receptor; V2 antagonist

Indexed keywords

MOZAVAPTAN; N TERT BUTYL 4 [5' ETHOXY 4 (2 MORPHOLINOETHOXY) 2' OXOSPIRO[CYCLOHEXANE 1,3' INDOLE] 1' SULFONYL] 3 METHOXYBENZAMIDE; PARTIAL AGONIST; UNCLASSIFIED DRUG; VASOPRESSIN ANTAGONIST; VASOPRESSIN DERIVATIVE; VASOPRESSIN V2 RECEPTOR; CYCLIC AMP; VASOPRESSIN RECEPTOR;

ANIMAL CELL; ARTICLE; CELL STRAIN; HUMAN; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; CELL STRAIN COS1; DRUG ANTAGONISM; DRUG POTENTIATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTAGENESIS; PROTEIN BINDING;

AMINO ACID SEQUENCE; ANIMALS; COS CELLS; CYCLIC AMP; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN BINDING; RECEPTORS, VASOPRESSIN;

EID: 0032217226     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(98)01585-3     Document Type: Article

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