Transfection of immature murine bone marrow-derived dendritic cells with the granulocyte-macrophage colony-stimulating factor gene potently enhances their in vivo antigen-presenting capacity

Journal of Immunology

Volumn 163, Issue 1, 1999, Pages 174-183

  Curiel Lewandrowski, Clara ^a   Mahnke, Karsten ^a   Labeur, Marta ^a   Roters, Berthold ^a   Schmidt, Walter ^b   Granstein, Richard D ^c   Luger, Thomas A ^a   Schwarz, Thomas ^a   Grabbe, Stephan ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF VIENNA   (Austria)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; GENETIC TRANSFECTION; IMMUNOSTIMULATION; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; PRIMARY IMMUNE RESPONSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, NEOPLASM; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL MOVEMENT; DENDRITIC CELLS; FEMALE; GENE TRANSFER TECHNIQUES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HAPTENS; HEMOCYANIN; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; MOLLUSCA; NEOPLASMS, EXPERIMENTAL; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033168146     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271.
2. Steinman, R. M., and J. Banchereau. 1998. Dendritic cells and the control of immunity. Nature 392:245.
3. Austyn, J. M., D. F. Hankins, C. P. Larsen, P. J. Morris, A. S. Rao, and J. A. Roake. 1994. Isolation and characterization of dendritic cells from mouse heart and kidney. J. Immunol. 152:2401.
4. Schuler, G., F. Koch, C. Heufler, E. Kämpgen, G. Topar, and N. Romani. 1993. Murine epidermal Langerhans cells as a model to study tissue dendritic cells. Adv. Exp. Med. Biol. 329:243.
5. Schuler, G. 1991. Epidermal Langerhans cells. CRC Press, Boca Raton.
6. Katz, S. I., K. Tamaki, and D. H. Sachs. 1979. Epidermal Langerhans cells are derived from cells originating in bone marrow. Nature 282:324.
7. Cella, M., F. Sallusto, and A. Lanzavecchia. 1997. Origin, maturation and antigen presenting function of dendritic cells. Curr. Opin. Immunol. 9:10.
8. Romani, N., S. Koide, M. Crowley, P. M. Witmer, A. M. Livingstone, C. G. Fathman, K. Inaba, and R. M. Steinman. 1989. Presentation of exogenous protein antigens by dendritic cells to T cell clones: intact protein is presented best by immature, epidermal Langerhans cells. J. Exp. Med. 169:1169.
9. Grabbe, S., S. Beissert, T. Schwarz, and R. D. Granstein. 1995. Dendritic cells as initiators of tumor immune responses: a possible strategy for tumor immunotherapy? Immunol. Today 16:117.
10. Schuler, G., and R. M. Steinman. 1997. Dendritic cells as adjuvants for immunemediated resistance to tumors. J. Exp. Med. 186:1183.
11. Hsu, F. J., C. Benike, F. Fagnoni, T. M. Liles, D. Czerwinski, B. Taidi, E. G. Engleman, and R. Levy R. 1996. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat. Med. 2:52.
12. Nestle, F. O., S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf. 1998. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat. Med. 4:328.
13. Grabbe, S., S. Bruvers, and R. D. Granstein. 1992. Effects of immunomodulatory cytokines on the presentation of tumor-associated antigens by epidermal Langerhans cells. J. Invest. Dermatol. 98:66s.
14. Jonuleit, H., J. Knop, and A. H. Enk. 1996. Cytokines and their effects on maturation, differentiation and migration of dendritic cells. Arch. Dermatol. Res. 289:1.
15. Schuler, G., and R. M. Steinman. 1985. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp. Med. 161:526.
16. Dranoff, G., E. Jaffee, A. Lazenby, P. Golumbek, H. Levitsky, K. Brose, V. Jackson, H. Hamada, D. Pardoll, and R. C. Mulligan. 1993. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA 90:3539.
17. Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R. M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:1693.
18. Mahnke, K., R. S. Bhardwaj, T. A. Luger, T. Schwarz, and S. Grabbe. 1996. Interaction of murine dendritic cells with collagen upregulates allostimulatory capacity, surface expression of heat stable antigen and release of cytokines. J. Leukocyte Biol. 60:465.
19. Wagner, E., K. Zatloukal, M. Gotten, H. Kirlappos, K. Mechtler, D. T. Curiel, and M. Birnstiel. 1992. Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor mediated gene delivery and expression of transfected genes. Proc. Natl. Acad. Sci. USA 89:6099.
20. Schmidt, W., T. Schweighoffer, E. Herbst, G. Maass, M. Berger, F. Schilcher, G. Schaffner, and M. L. Birnstiel. 1995. Cancer vaccines: the interleukin 2 dosage effect. Proc. Natl. Acad. Sci. USA 92:4711.
21. Grabbe, S., R. L. Gallo, A. Lindgren, and R. D. Granstein. 1993. Deficient antigen presentation by Langerhans cells from athymic (nu/nu) mice: restoration with thymic transplantation or administration of cytokines. J. Immunol. 151: 3430.
22. Shimonkevitz, R., S. Colon, J. Kappler, P. Marrack, and H. Grey. 1984. Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen. J. Immunol. 133:2067.
23. Grabbe, S., K. Steinbrink, M. Steinert, T. A. Luger, and T. Schwarz. 1995. Removal of the majority of epidermal Langerhans cells by topical or systemic steroid application enhances the effector phase of murine contact hypersensitivity. J. Immunol. 155:4207.
24. Grabbe S., S. Bruvers, R. L. Gallo, T. L. Knisely, R. Nazareno, and R. D. Granstein. 1991. Tumor antigen presentation by murine epidermal cells. J. Immunol. 146:3656.
25. Knight, S. C., R. Hunt, C. Dore, and P. B. Medawar. 1985. Influence of dendritic cells on tumor growth. Proc. Natl. Acad. Sci. USA 82:4495.
26. Romani, N., D. Reider, M. Heuer, S. Ebner, E. Kämpgen, B. Eibl, D. Niederwieser, and G. Schuler. 1996. Generation of mature dendritic cells from human blood: an improved method with special regard to clinical application. J. Immunol Methods 196:137.
27. Czerniecki, B. J., C. Carter, L. Rivoltini, G. K. Koski, H. I. Kim, D. E. Weng, J. G. Roros, Y. M. Hijazi, S. Xu, S. A. Rosenberg, and P. A. Cohen. 1997. Calcium ionophore-treated peripheral blood monocytes and dendritic cells rapidly display characteristics of activated dendritic cells. J. Immunol. 159:3823.
28. Jonuleit, H., U. Kuhn, G. Müller, K. Steinbrink, L. Paragnik, E. Schmitt, J. Knop, and A H. Enk. 1997. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur. J. Immunol. 27:3135.
29. Celluzzi, C. M., J. I. Mayordomo, W. J. Storkus, M. T. Lotze, and L. D. Falo jr. 1996. Peptide pulsed dendritic cells induce antigen-specific, CTL-mediated protective tumor immunity. J. Exp. Med. 183:283.
30. Mayordomo, J. I., T. Zorina, W. J. Storkus, L. Zitvogel, C. Celluzzi, L. D. Falo, C. J. Melief, S. T. Ilstad, W. M. Kast, A. B. Deleo, and M. T. Lotze. 1995. Bone marrow-derived dendritic cells pulsed with synthetic tumor peptides elicit protective and therapeutic antitumor immunity. Nat. Med. 1:1297.
31. Paglia, P., C. Chiodoni, M. Rodolfo, and M. P. Colombo. 1996. Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo. J. Exp. Med. 183:317.
32. Zitvogel, L., J. I. Mayordomo, T. Tjandrawan, A. B. Deleo, M. R. Clarke, M. T. Lotze, and W. J. Storkus. 1996. Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J. Exp. Med. 183:87.
33. Pogador, A., D. Snyder, and E. Gilboa. 1996. Induction of antitumor immunity using bone marrow-generated dendritic cells. J. Immunol. 156:2918.
34. Labeur, M., B. Roters, B. Pers, A. Mehling, T. A. Luger, T. Schwarz, and S. Grabbe. 1999. Tumor antigen presenting capacity of bone marrow-derived dendritic cells correlates with maturation stage and migratory capacity. J. Immunol. 162:168.
35. Brossart, P., A.W. Goldrath, E. A. Butz, S. Martin, and M. J. Bevan. 1997. Virus-mediated gene delivery of antigenic epitopes into dendritic cells as a means to induce CTL. J. Immunol. 158:3270.
36. Wan, Y., J. Bramson, R. Carter, F. Graham, and J. Gauldie. 1997. Dendritic cells transduced with an adenoviral vector encoding a model tumor-associated antigen for tumor vaccination. Hum. Gene Ther. 8:1355.
37. Song, W., H. L. Kong, H. Carpenter, H. Torii, R. D. Granstein, S. Rafii, M. A. Moore, and R. G. Crystal. 1997. Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity. J. Exp. Med. 186:1247.
38. Gong, J., L. Chen, D. Chen, M. Kashiwaba, Y. Manome, T. Tanaka, and D. Kufe. 1997. Induction of antigen-specific antitumor immunity with adenovirus-transduced dendritic cells. Gene Ther. 4:1023.
39. Dietz, A. B, and S. Vuk-Pavlovic. 1998. High efficiency adenovirus-mediated gene transfer to human dendritic cells. Blood 91:392.
40. Specht, J.M., G. Wang, M. T. Do, J. S. Lam, R. E. Royal, M. E. Reeves, S. A. Rosenberg, and P. Hwu. 1997. Dendritic cells retrovirally transduced with a model antigen are therapeutically effective against established pulmonary metastases. J. Exp. Med. 186:1213.
41. Mulders, P., S. Pang, J. Dannull, R. Kaboo, A. Hinkel, K. Michel, C. L. Tso, M. Roth, and A. Belldegrun. 1998. Highly efficient and consistent gene transfer into dendritic cells utilizing a combination of ultraviolet-irradiated adenovirus and poly(L-lysine) conjugates. Cancer Res. 58:956.
42. Golumbek P. T., R. Azhari, E. M. Jaffee, H. I. Levitsky, A. Lazenby, K. Leong, and D. M. Pardoll. 1993. Controlled release, biodegradable cytokine depots: a new approach in cancer vaccine design. Cancer Res. 53:5841.
43. Qin, Z., G. Noffz, M. Mohaupt, and T. Blankenstein. 1997. Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte-macrophage colony stimulating factor gene-modified tumor cells. J. Immunol. 159:770.
44. Tazi, A., F. Bouchonnet, M. Grandsaigne, L. Boumsell, A. J. Hance, and P. Soler. 1993. Evidence that granulocyte macrophage-colony-stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers. J. Clin. Invest. 91:566.
45. Kaplan, G., G. Walsh, L. S. Guido, P. Meyn, R. A. Burkhardt, R. M. Abalos, J. Barker, P. A. Frindt, T. T. Fajardo, R. Celona, and Z. A. Cohn. 1992. Novel responses of human skin to intradermal recombinant granulocyte/macrophage-colony-stimulating factor Langerhans cell recruitment, keratinocyte growth, and enhanced wound healing. J. Exp. Med. 175:1717.
46. Cella, M., A. Engering, V. Pinet, J. Pieters, and A. Lanzavecchia. 1997. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 388:724.