Requirements for bone marrow-derived antigen-presenting cells in priming cytotoxic T cell responses to intracellular pathogens

Journal of Experimental Medicine

Volumn 192, Issue 8, 2000, Pages 1135-1142

  Lenz, Laurel L ^a,b   Butz, Eric A ^a,c   Bevan, Michael J ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c AMGEN INC   (United States)

Author keywords

Bacterial immunity; Cross presentation; Cytotoxic T cell; Radiation chimera; Viral immunity

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; BACTERIAL IMMUNITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; IMMUNE RESPONSE; INFECTION; LISTERIA MONOCYTOGENES; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION CHIMERA; VACCINIA VIRUS; VIRUS IMMUNITY;

ANIMALS; ANTIGEN-PRESENTING CELLS; BONE MARROW CELLS; CHIMERA; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NUCLEOPROTEINS; T-LYMPHOCYTES, CYTOTOXIC; VACCINIA; VACCINIA VIRUS;

EID: 0034675955     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.8.1135     Document Type: Article

References (37)

1. Dendritic cells and the control of immunity
2. DC-SIGN: A guide to some mysteries of dendritic cells
3. CD28/B7 system of T cell costimulation
4. + T-helper and a T-killer cell
5. Help for cytotoxic-T-cell responses is mediated by CD40 signalling
6. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
7. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay
8. Minor H antigens introduced on H-2 different stimulating cells cross-react at the cytotoxic T cell level during in vivo priming
9. Cross-presentation: A general mechanism for CTL immunity and tolerance
10. Cytotoxic T lymphocyte activation by cross-priming
11. Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells
12. The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites
13. Gene vaccination with naked plasmid DNA: Mechanism of CTL priming
14. In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter
15. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
16. - tumour cells
17. + T cells by semiprofessional antigen-presenting cells in vivo
18. Fibroblasts as efficient antigen-presenting cells in lymphoid organs
19. Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity
20. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence
21. Presentation of exogenous protein antigens on major histocompatibility complex class I molecules by dendritic cells: Pathway of presentation and regulation by cytokines
22. Identification of an H2-M3-restricted Listeria epitope: Implications for antigen presentation by M3
23. Differential presentation of the same MHC class I epitopes by fibroblasts and dendritic cells
24. Selecting and maintaining a diverse T-cell repertoire
25. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen
26. Macrophages as accessory cells for class I MHC-restricted immune responses
27. + T cells
28. Coordinate regulation of complex T cell populations responding to bacterial infection
29. Compartmentalization of bacterial antigens: Differential effects on priming of CD8 T cells and protective immunity
30. Lymphohemopoietic origin of the immunogenic, virus-antigen-presenting cells triggering anti-viral T-cell responses
31. Bone marrow-derived antigen presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and -independent pathways of antigen presentation
32. Barrier cells in the spleen
33. Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody
34. Differential T cell costimulatory requirements in CD28-deficient mice
35. A comparison of T cell memory against the same antigen induced by virus versus intracellular bacteria
36. + T cells during an acute virus infection
37. Counting antigen-specific CD8 T cells: A reevaluation of by-stander activation during viral infection