Tau and HMW tau phosphorylation and compartmentalization in apoptotic neuronal PC12 cells

Journal of Neuroscience Research

Volumn 66, Issue 2, 2001, Pages 203-213

  Shelton, Shirley B ^a   Johnson, Gail V W ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Alzheimer disease; Caspase 3; Cytoskeleton; Microtubule

Indexed keywords

CASPASE 3; CELL MEMBRANE PROTEIN; LACTATE DEHYDROGENASE; NERVE GROWTH FACTOR; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOSKELETON; DEPHOSPHORYLATION; ENZYME ACTIVITY; ENZYME RELEASE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ALZHEIMER DISEASE; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL COMPARTMENTATION; CELL MEMBRANE; CELL SIZE; CULTURE MEDIA, SERUM-FREE; L-LACTATE DEHYDROGENASE; MICROTUBULES; MOLECULAR WEIGHT; NEURITES; NEURONS; PC12 CELLS; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; SOLUBILITY; TAU PROTEINS;

EID: 0035888286     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.1212     Document Type: Article

References (56)

1. Apoptosis and autophagy in nigral neurons of patients with Parkinson disease
2. Regulation of microtubule dynamics by microtubule-associated protein expression and phosphorylation during neuronal development
3. Regulated phosphorylation and dephosphorylation of tau protein: Effects on microtubule interaction, intracellular trafficking and neurodegeneration
4. The distribution of tau in the mammalian central nervous system
5. Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain
6. Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis
7. Primary structure of high molecular weight tau present in the peripheral nervous system
8. Select alterations in protein kinases and phosphatases during apoptosis of differentiated PC12 cells
9. Energy metabolism and protein phosphorylation during apoptosis: A phosphorylation study of tau and high-molecular-weight tau in differentiated PC12 cells
10. The microtubule binding of Tau and high molecular weight Tau in apoptotic PC12 cells is impaired because of altered phosphorylation
11. In situ evidence for DNA fragmentation in Huntington disease striatum and Alzheimer disease temporal lobes
12. Phosphorylation of tau alters its association with the plasma membrane
13. Expression of high molecular weight tau in the central and peripheral nervous systems
14. Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system
15. Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer disease
16. The central executioners of apoptosis: Caspases or mitochondria?
17. Apoptotic pathways: The roads to ruin
18. Apoptotic pathways: Paper wraps stone blunts scissors
19. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells that respond to nerve growth factor
20. Downregulation of actin genes precedes microfilament network disruption and actin cleavage during p53-mediated apoptosis
21. 14-13-3zeta is an effector of tau protein phosphorylation
22. SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis
23. Tau complexes with phospholipase C-gamma in situ
24. Modulation of tau phosphorylation and intracellular localization by cellular stress
25. Proteolysis of tau by calpain
26. Tau protein in normal and Alzheimer disease brain: An update
27. Transient oxidative stress in SH-SY5Y human neuroblastoma cells results in caspase dependent and independent cell death and tau proteolysis
28. Induction of Alzheimer-specific Tau epitope AT100 in apoptotic human fetal astrocytes
29. Tau interacts with src-family non-receptor tyrosine kinases
30. Identification of tau protein regions required for process formation in PC12 cells
31. Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons
32. Actin polymerization and depolymerization during apoptosis in HL-60 cells
33. Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments
34. A spatial gradient of tau protein phosphorylation in nascent axons
35. Activation of a PP2A-like phosphatase and dephosphorylation of tau protein characterize onset of the execution phase of apoptosis
36. Extranuclear apoptosis. The role of the cytoplasm in the execution phase
37. Histochemical detection of apoptosis in Parkinson disease
38. Caspase structure, proteolytic substrates, and function during apoptotic cell death
39. Aberrant tau phosphorylation and neurite retraction during NGF deprivation in PC12 cells
40. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
41. A system for characterizing cellular and molecular events in programmed neuronal cell death
42. Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models
43. Complementary distribution of tau proteins in different phosphorylation states within growing axons
44. Apoptosis: The biochemistry and molecular biology of programmed cell death
45. Executioner caspases-3, -6 and -7 performs distinct, non-redundant, roles during the demolition phase of apoptosis
46. Evidence for apoptotic cell death in Alzheimer disease
47. Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A
48. Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis
49. Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independendy of caspase-3 (CPP32)- like activity
50. Caspases: Controlling intracellular signals by protease zymogen activation
51. Immunohistochemical evidence for apoptosis in Alzheimer disease
52. Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location
53. Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells
54. Plasma membrane alterations and cytoskeletal changes in apoptosis
55. A protein factor essential for microtubule assembly
56. Tau protein is hyperphosphorylated in a site-specific manner in apoptotic neuronal PC12 cells