Induction of Alzheimer-specific tau epitope AT100 in apoptotic human fetal astrocytes

Cell Motility and the Cytoskeleton

Volumn 47, Issue 3, 2000, Pages 236-252

  Ksiezak Reding, Hanna ^a   He, Deke ^a   Gordon Krajcer, Wanda ^a   Kress, Yvonne ^a   Lee, Sunhee ^a   Dickson, Dennis W ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Alzheimer's disease; Apoptosis; Okadaic acid; Primary cultures; Tau phosphorylation; Tau protein

Indexed keywords

ANTIBODY; EPITOPE; OKADAIC ACID; PROTEIN KINASE B; TAU PROTEIN;

ALZHEIMER DISEASE; ANTIGEN BINDING; APOPTOSIS; ARTICLE; ASTROCYTE; CELL CULTURE; CHROMATIN CONDENSATION; CONTROLLED STUDY; FETUS; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

ALTERNATIVE SPLICING; ALZHEIMER DISEASE; ANTIBODIES; APOPTOSIS; ASTROCYTES; BRAIN; CDC2 PROTEIN KINASE; CELL FRACTIONATION; CELL MEMBRANE; CELL NUCLEUS; CELLS, CULTURED; CHROMATIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA FRAGMENTATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITOPES; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICROSCOPY, ELECTRON; OKADAIC ACID; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TAU PROTEINS; TIME FACTORS; UP-REGULATION;

EID: 0033744467     PISSN: 08861544     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0169(200011)47:3<236::AID-CM6>3.0.CO;2-K     Document Type: Article

References (89)

1. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase
2. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors
3. Okadaic acid induces early changes in microtubule-associated protein 2 and tau phosphorylation prior to neurodegeneration in cultured cortical neurons
4. Stable expression of heterologous microtubule-associated proteins (MAPs) in chinese hamster ovary cells: Evidence for differentiating roles of MAPs in microtubule organization
5. The development of cell processes induced by tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains
6. Production of paired helical filament, tau-like proteins by PC12 cells: A model of neurofibrillary degeneration
7. Presence of tau in isolated nuclei from human brain
8. The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology
9. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
10. Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies
11. Reversible heat-stress-related loss of phosphorylated Alzheimer-type epitopes in tau proteins of human neuroblastoma cells
12. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
13. Microtubule-associated proteins and in vitro astrocyte differentiation
14. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
15. Energy metabolism and protein phosphorylation during apoptosis: A phosphorylation study of tau and high-molecular-weight tau in differentiated PC12 cells
16. Select alterations in protein kinases and phosphatases during apoptosis of differentiated PC12 cells
17. Establishment of human adult astrocyte cultures derived from multiple sclerosis and control brain and spinal cord regions: Immunophenotypical and functional characterization
18. Corticobasal degeneration: Neuropathologic and molecular considerations
19. Tau protein function in living cells
20. Regulation of neuronal survival by the serine-threonine protein kinase Akt
21. Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: Implications for Alzheimer's disease
22. Intermediate filament protein partnership in astrocytes
23. Neuronal apoptosis is associated with a decrease in tau mRNA expression
24. Postmortem changes in the phosphorylation state of tau-protein in the rat brain
25. Protein phosphorylation in apoptosis
26. Neurofibrillary pathology of Alzheimer's disease and other tauopathies
27. Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205
28. Localization and in situ phosphorylation state of nuclear tau
29. 5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10
30. Energy metabolism
31. Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase
32. Akt signaling-linking membrane events to life and death decisions
33. Okadaic acid induces hyperphosphorylation of tau independently of mitogen-activated protein kinase activation
34. Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites
35. Modulation of the glycogen synthase kinase 3-family by tyrosine phosphorylation
36. Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau
37. cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease
38. The extent of phosphorylation of fetal tau is comparable to that of PHF-tau from Alzheimer paired helical filaments
39. Sequence of neurodegeneration and accumulation of phosphorylated tau in cultured neurons after okadaic acid treatment
40. A novel direct interaction of endoplasmic reticulum with microtubules
41. Epitopes that span the tau molecule are shared with paired helical filaments
42. Mass and physical dimensions differ in two distinct populations of paired helical filaments
43. Binding of Alz 50 depends on Phe8 in tau synthetic peptides and varies between native and denatured tau proteins
44. Ultrastructural instability of paired helical filaments from corticobasal degeneration as examined by scanning transmission electron microscopy
45. A distinct subset of tau isoforms is expressed in bovine brain oligodendrocytes
46. Expression of tau protein in non-neuronal cells: Microtubule binding and stabilization
47. Tau interacts with src-family non-receptor tyrosine kinases
48. Characterization of primary human fetal dissociated central nervous system cultures with an emphasis on microglia
49. Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356
50. Cytoskeletal alterations in human fetal astrocytes induced by interleukin-1β
51. Detection of a Cdc2-related kinase associated with Alzheimer paired helical filaments
52. Functional implications for the microtubule-associated protein tau: Localization in oligodendrocytes
53. The phosphorylation of tau: A critical stage in neurodevelopment and neurodegenerative processes
54. Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
55. Alzheimer-specific epitope of AT100 in transfected cell lines with tau: Toward an efficient cell model of tau abnormal phosphorylation
56. Phosphorylation of specific sets of tau isoforms reflects different neurofibrillary degeneration processes
57. Tau domains, phosphorylation, and interactions with microtubules
58. Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
59. Activation of a PP2A-like phosphatase and dephosphorylation of tau protein characterize onset of the execution phase of apoptosis
60. Expression of microtubule-associated proteins MAP2 and tau in cultured rat brain oligodendrocytes
61. Sodium butyrate induces aberrant tau phosphorylation and programmed cell death in human neuroblastoma cells
62. Aberrant phosphorylation and neurite retraction during NGF deprivation in PC12 cells
63. Okadaic acid-induced apoptosis in neuronal cells: Evidence for an abortive mitotic attempt
64. Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396-404
65. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
66. Cloning, localization and induction of mouse brain glycogen synthase
67. Fibrous and protoplasmic astrocytes
68. The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells
69. Microtubule-associated proteins regulate microtubule function as the track for intracellular membrane organelle transports
70. Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for β-structureq
71. Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly
72. Different distribution of phosphorylated tau protein isoforms in Alzheimer's and Pick's diseases
73. Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau
74. A 26-30 kDa developmentally-regulated tau isoform localized within nuclei of mitotic human neuroblastoma cells
75. Phosphatase inhibition in human neuroblastoma cells alters tau antigenicity and renders it incompetent to associate with exogenous microtubules
76. Expression of cell cycle-related genes during neuronal apoptosis: Is there a distinct pattern?
77. The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: The role of protein phosphatases
78. Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB
79. Increased production of paired helical filament epitopes in a cell culture system reduces the turnover of tau
80. Mitotic mechanisms in Alzheimer's disease?
81. Aberrant expression of mitotic Cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain
82. Endoplasmic reticulum membrane tubules are distributed by microtubules in living cells using three distinct mechanisms
83. GSK3: A SHAGGY frog story
84. Metabolic pathways for glucose in astrocytes
85. Roles of glycogen synthase kinase-3 in signal transduction
86. The interrelationship between selective tau phosphorylation and microtubule association
87. Tau released from paired helical filaments with formic acid or guanidine is susceptible to calpain-mediated proteolysis
88. Sequential phosphorylation of tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation