Monitor: Molecules and profiles

Drug Discovery Today

Volumn 6, Issue 18, 2001, Pages 962-964

  Langston, Steven ^a   Barlocco, Daniela ^b  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ANTIINFLAMMATORY AGENT; AZOLIDINEDIONE DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; DIARYLSULFIDE CYCLOPROPYLAMIDE DERIVATIVE; INTERCELLULAR ADHESION MOLECULE 1; ISOENZYME; ISOQUINOLINE DERIVATIVE; LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; STYRYLBENZENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; BRAIN; CLINICAL TRIAL; DRUG BIOAVAILABILITY; DRUG DEVELOPMENT; DRUG RESEARCH; HUMAN; MOLECULE; NONHUMAN; SHORT SURVEY;

EID: 0035885287     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(01)01946-8     Document Type: Short Survey

References (13)

1. 3,4-Dihydro-1-isoquinolinamines: A novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency
2. Thienopyridines: Nitric oxide synthase inhibitors with potent in vivo activity
3. 3 agonists
4. 3 agonists
5. Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead
6. Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists
7. Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams
8. The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase - GW311616A, a development candidate
9. Imaging Alzheimer's amyloid
10. Small molecule β-amyloid probes which distinguish homogenates of Alzheimer's and control brains
11. Chrysamine G, a lipophilic analogue of Congo red, inhibits Aβ-induced toxicity in PC12 cells
12. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease
13. Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)-styrylbenzene in strong base: probes for Amyloid plaques in the brain