Curcumin inhibits activation of Vγ9Vδ2 T cells by phosphoantigens and induces apoptosis involving apoptosis-inducing factor and large scale DNA fragmentation

Journal of Immunology

Volumn 167, Issue 6, 2001, Pages 3454-3462

  Cipriani, B ^a   Borsellino, G ^a   Knowles, H ^a   Tramonti, D ^a   Cavaliere, F ^a   Bernardi, G ^a   Battistini, L ^a   Brosnan, C F ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; CHEMOKINE; CURCUMIN; DNA FRAGMENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 15; INTERLEUKIN 2; LIPOCORTIN 5; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RANTES; TRANSCRIPTION FACTOR AP 1;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL WALL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG INHIBITION; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULSED FIELD GEL ELECTROPHORESIS;

EID: 0035884995     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.6.3454     Document Type: Article

References (43)

1. Stimulation of γδ T cells by phosphoantigens
2. Human γδ T cells recognize alkylamines derived from microbes, edible plants, and tea: Implications for innate immunity
3. Sentinel function of broadly reactive human γδ T cells
4. Multiple sclerosis: Limited diversity of the Vδ2-Jδ3 T-cell receptor in chronic active lesions
5. Activation of γδ T cells by mycobacterial antigens in rheumatoid arthritis
6. Natural and synthetic non-peptide antigens recognized by human gamma delta T cells
7. Crucial role of TCR γ-chain junctional region in prenyl pyrophosphate antigen recognition by γδ T cells
8. CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive Vγ9Vδ2 T lymphocytes
9. Activation of C-C β-chemokines in human peripheral blood γδ T cells by isopentenyl pyrophosphate and regulation by cytokines
10. Transcriptional regulation of T lymphocyte development and function
11. C/EBP, NF-κB, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1α immediate-early gene
12. Regulation of RANTES chemokine gene expression requires cooperativity between NF-κB and IFN-regulatory factor transcription factors
13. NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules
14. Curcumin blocks cytokine-mediated NF-κB activation and proinflammatory gene expression by inhibiting inhibitory factor I-κB kinase activity
15. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(κ)B kinase-β
16. Traditional Indian systems of medicine
17. Activation of transcription factor NF-κB is suppressed by curcumin
18. L, NF-κB, and p53
19. L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis
20. A novel apoptosis-like pathway, independent of mitochondria and caspases, induced by curcumin in human lymphoblastoid T (Jurkat) cells
21. Phytochemicals as modulators of cancer risk
22. Progress in cancer chemoprevention: Development of diet-derived chemopreventive agents
23. Modulation of interleukin-1β and tumor necrosis factor α signaling by P2 purinergic receptors in human fetal astrocytes
24. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
25. IL-15 enhances the response of human γδ T cells to non-peptide
26. A novel assay for apoptosis: Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V
27. Annexin V binds to viable B cells and colocalizes with a marker of lipid rafts upon B cell receptor activation
28. Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies
29. Roles of poly ADP-ribosylation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1
30. Apoptosis of a fibrosarcoma induced by protein-free culture involves DNA cleavage to large fragments but not internucleosomal fragmentation
31. Two distinct pathways leading to nuclear apoptosis
32. Molecular characterization of mitochondrial apoptosis-inducing factor
33. Mitochondrionuclear translocation of AIF in apoptosis and necrosis
34. Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells
35. Apoptosis-independent alterations in membrane dynamics induced by curcumin
36. Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin
37. Enhanced apoptosis mediates inhibition of EBV-transformed lymphoblastoid cell line proliferation by curcumin
38. Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines
39. Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution
40. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
41. Apoptosis: Death of a monopoly?
42. Tumor necrosis factor-α production is differently regulated in γδ and αβ human T lymphocytes
43. Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells