IL-10-deficient B10.Q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type II collagen antibodies

Journal of Immunology

Volumn 167, Issue 6, 2001, Pages 3505-3512

  Johansson, A C M ^a   Hansson, A S ^a   Nandakumar, K S ^a   Backlund J ^a   Holmdahl, R ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; COLLAGEN; COLLAGEN ANTIBODY; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; T LYMPHOCYTE;

EID: 0035884447     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.6.3505     Document Type: Article

References (60)

1. Type II collagen induced arthritis in mice. I. Major histocompatibility complex (1-region) linkage and antibody correlates
2. Genetics of susceptibility to chronic experimental encephalomyelitis and arthritis
3. Genetic control of collagen-induced arthritis in a cross with NOD and C57BL/10 mice is dependent on gene regions coding for complement factor 5 and FcγRIIb and is not associated with loci controlling diabetes
4. In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis. Sjogren's syndrome, and systemic lupus erythematosus: A potential mechanism of B lymphocyte hyperactivity and autoimmunity
5. Immunoregulatory role of interleukin 10 in rheumatoid arthritis
6. High level of interleukin-10 production by the activated T cell population within the rheumatoid synovial membrane
7. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
8. Interleukin-10
9. IL-10 inhibits cytokine production by activated macrophages
10. IL-10 stimulates monocyte FcγR surface expression and cytotoxic activity: Distinct regulation of antibody-dependent cellular cytotoxicity by IFN-γ, IL-4, and IL-10
11. IL-10: A novel cytotoxic T cell differentiation factor
12. Interleukin 10, a novel B cell stimulatory factor: Unresponsiveness of X chromosome-linked immunodeficiency B cells
13. Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium
14. Interleukin-10 suppresses the development of collagen type II-induced arthritis and ameliorates sustained arthritis in rats
15. Interleukin-10 inhibition of the progression of established collagen-induced arthritis
16. Effect of IL-10 on collagen-induced arthritis in mice
17. Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis
18. Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer
19. Synergistic protection against cartilage destruction by low dose prednisolone and interleukin-10 in established murine collagen arthritis
20. Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis: Protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction
21. Interleukin-10-deficient mice develop chronic enterocolitis
22. Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis
23. Analysis of type II collagen reactive T cells in the mouse. I. Different regulation of autoreactive versus non-autoreactive anti-type II collagen T cells in the DBA/1 mouse
24. Preparation and characterization of the different types of collagen
25. High antibody response to autologous type II collagen is restricted to H-2q
26. B cell-deficient mice do not develop type II collagen-induced arthritis (CIA)
27. IL-10 up-regulates nitric oxide (NO) synthesis by lipopolysaccharide (LPS)-activated macrophages: Improved control of Trypanosoma cruzi infection
28. The mouse Igh-1a and Igh-1b H chain constant regions are derived from two distinct isotypic genes
29. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
30. Collagen-induced arthritis in mice: Synergistic effect of E. coli lipopolysaccharide bypasses epitope specificity in the induction of arthritis with monoclonal antibodies to type II collagen
31. Production of interleukin 10 by islet cells accelerates immune-mediated destruction of β cells in nonobese diabetic mice
32. Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice
33. IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity
34. Th1 to Th2 cytokine shifts in nonobese diabetic mice: Sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation
35. Degradable polymeric carrier for the delivery of IL-10 plasmid DNA to prevent autoimmune insulitis of NOD mice
36. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery
37. Acceleration of experimental autoimmune encephalomyelitis in interleukin-10-deficient mice: Roles of interleukin-10 in disease progression and recovery
38. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice
39. Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis
40. IL-10 fails to abrogate experimental autoimmune encephalomyelitis
41. Genetic control of susceptibility to collagen-induced arthritis in T cell receptor β-chain transgenic mice
42. Genetic linkage analysis of collagen-induced arthritis in the mouse
43. Identification of genes controlling collagen-induced arthritis in mice: Striking homology with susceptibility loci previously identified in the rat
44. Genetic influence on disease course and cytokine response in relapsing experimental allergic encephalomyelitis
45. Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines
46. The production of two Th2 cytokines, interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively
47. Non-major histocompatibility complex dependent variations in lymphocyte activity between inbred mouse strains susceptible to various autoimmune diseases
48. + T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis
49. Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen
50. T lymphocytes are not required for the spontaneous development of entheseal ossification leading to marginal ankylosis in the DBA/1 mouse
51. (+) TH1-like responses
52. Heritable susceptibility for colitis in mice induced by IL-10 deficiency
53. Susceptibility to collagen-induced arthritis: Cytokine-mediated regulation
54. A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia
55. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression
56. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses
57. + CTLs in vivo
58. Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws
59. Amelioration of established collagen induced arthritis by systemic IL-10 gene delivery
60. Viral IL-10 and soluble TNF receptor act synergistically to inhibit collagen-induced arthritis following adenovirus-mediated gene transfer