Genetic influence on disease course and cytokine response in relapsing experimental allergic encephalomyelitis

International Immunology

Volumn 10, Issue 3, 1998, Pages 333-340

  Kjellén, Peter ^a   Issazadeh, Shohreh ^a   Olsson, Tomas ^b   Holmdahl, Rikard ^a  

^a LUND UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Autoimmunity; MHC; Myelin basic protein; Spinal cord homogenate

Indexed keywords

CYTOKINE; FREUND ADJUVANT; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; IMMUNE RESPONSE; IMMUNIZATION; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; SPLEEN CELL;

AMINO ACID SEQUENCE; ANIMALS; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENETIC PREDISPOSITION TO DISEASE; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; RATS; RATS, INBRED LEW; RNA, MESSENGER; SPINAL CORD;

EID: 0031915079     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.3.333     Document Type: Article

References (25)

1. Sundvall, M., Jirholt, J., Yang, H.-T., Jansson, L., Engström, Å., Pettersson, U. and Holmdahl, R. 1995. Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis. Nat. Genet. 10:313.
2. Baker, D., Rosenwasser, O. A., O'Neill, J. K. and Turk, J. L. 1995. Genetic analysis of experimental allergic encephalomyelitis in mice. J. Immunol. 155:4046.
3. Encinas, J. A., Lees, M. B., Sobel, R. A., Symonowicz, C., Greer, J. M., Shovlin, C. L., Weiner, H. L., Seidman, C. E., Seidman, J. G. and Kuchroo, V. K, 1996. Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10. S mice. J. Immunol. 157:2186.
4. Kuokkanen, S., Sundvall, M., Terwilliger, J. D., Tienari, P. J., Wikström, J., Holmdahl, R., Pettersson, U. and Peltonen, L. 1996. A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2. Nat. Genet. 13:477.
5. Haines, J. L., Ter-Minassian, M., Bazyk, A., Gusella, J. F., Kim, D. J., Terwedow, H., Pericak-Vance, M. A., Rimmler, J. B., Haynes, C. S., Roses, A. D., Lee, A., Shaner, B., Menold, M., Seboun, E., Fitoussi, R. P., Gartioux, C., Reyes, C., Ribierre, F., Gyapay, G., Weissenbach, J., Hauser, S. L., Goodkin, D. E., Lincoln, R., Usuku, K. Oksenberg, J. R., et al. 1996. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. The Multiple Sclerosis Genetics Group. Nat. Genet. 13:469.
6. Horack, H. M. 1930. Allergy as a factor in the development of reactions to anti-rabic treatment. Am. J. Med. Sci. 197:672.
7. Paterson, P. Y. 1966. Experimental allergic encephalomyelitis and autoimmune disease. Adv. Immunol. 5:131.
8. Gasser, D. L., Palm, J. and Gonatas, N. K. 1975. Genetic control of susceptibility to experimental allergic encephalomyelitis and the Ag-B locus of rats. J. Immunol. 115:431.
9. Günther, E., Odenthal, H. and Wechsler, W. 1978. Association between susceptibility to experimental allergic encephalomyelitis and the major histocompatibility system in congenic rat strains. Clin. Exp Immunol. 32:429.
10. Chluba, J., Steeg, C., Becker, A., Wekerle, H. and Epplen, J. T. 1989. T cell receptor beta chain usage in myelin basic protein-specific rat T lymphocytes. Eur. J. Immunol. 19:279.
11. Javed, N. H., Gienapp, I. E., Cox, K. L. and Whitacre, C. C. 1995. Exquisite peptide specificity of oral tolerance in experimental autoimmune encephalomyelitis. J. Immunol. 155:1599.
12. Happ, M. P. and Heber, K. E. 1988. Differences in the repertoire of the Lewis rat T cell response to self and non-self myelin basic proteins. J. Exp. Med. 167:502.
13. Lorentzen, J. C., Issazadeh, S., Storch, M., Mustafa, M. I., Lassman, H., Linington, C., Klareskog, L. and Olsson, T. 1995. Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant. J. Neuroimmunol. 63:193.
14. Holmdahl, R., Vingsbo, C., Hedrich, H., Karlsson, M., Kvick, C. Goldschmidt, T. J. and Gustafsson, K. 1992. Homologous collagen-induced arthritis in rats and mice are associated with structurally different major histocompatibility complex DQ-like molecules. Eur. J. Immunol. 22:419.
15. Holmdahl, R., Goldschmidt, T. J., Kleinau, S., Kvick, C. and Jonsson, R. 1992. Arthritis induced in rats with adjuvant oil is a genetically restricted, alpha beta T-cell dependent autoimmune disease. Immunology 76:197.
16. Issazadeh, S., Lorentzen, J. C., Mustafa, M. I., Höjeberg, B., Mussener, Å. and Olsson, T. 1996. Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-beta. J. Neuroimmunol. 69:103.
17. Hedrich, H. J., ed. 1990. Genetic Monitoring of Inbred Strains of Rats. Gustaf Fischer Verlag, Stuttgart.
18. Issazadeh, S., Kjellen, P., Olsson, T., Mustafa, M. and Holmdahl, R. 1997. The genetic association of a protective influence on the development of EAE in rats is dependent on both the specific MHC class Il molecule and the myelin basic protein peptide. Eur. J. Immunol. 27:1584.
19. Mustafa, M., Vingsbo, C., Olsson, T., Issazadeh, S., Ljungdahl, A. and Holmdahl, R. 1994. Protective influences on experimental autoimmune encephalomyelitis by MHC class I and class II alleles. J. Immunol. 153:3337.
20. Holmdahl, R., Vingsbo, C., Mo, J., Michaelsson, E., Malmström, V., Jansson, L. and Brunsberg, U. 1995. Chronicity of tissue-specific experimental autoimmune disease. A role for B cells? Immunol. Rev. 144:109.
21. Jansson, L., Diener, P., Engström, Å., Olsson, T. and Holmdahl, R. 1995. Spreading of the immune response to different myelin basic protein peptides in chronic experimental autoimmune encephalomyelitis in B10.RIII mice. Eur. J. Immunol. 25:2195.
22. Miller, A., al Sabbagh, A., Santos, L. M. B., Das, M. P. and Weiner, H. L. 1993. Epitopes of myelin basic protein that trigger TGF-β release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression. J. Immunol. 151:7307.
23. Mustafa, M., Vingsbo, C., Olsson, T., Ljungdahl, A., Höjeberg, B. and Holmdahl, R. 1993. The major histocompatibility complex influences myelin basic protein 63-88- induced T cell cytokine profile and experimental autoimmune encephalomyelitis. Eur. J. Immunol. 23:3089.
24. Stepaniak, J. A., Gould, K. E., Sun, D. and Swanborg, R. H. 1995. A comparative study of experimental autoimmune encephalomyelitis in Lewis and DA rats. J. Immunol. 155:2762.
25. Vingsbo, C., Sahlstrand, P., Brun, J. G., Jonsson, R., Saxne, T. and Holmdahl, R. 1996. Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes. Am. J Pathol. 149:1675.