Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 9, 1996, Pages 4480-4485

  Malmström, Vivianne ^a   Michaëlsson, Erik ^a   Burkhardt, Harald ^b   Mattsson, Ragnar ^c   Vuorio, Eero ^d   Holmdahl, Rikard ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UPPSALA UNIVERSITY   (Sweden)

^d UNIVERSITY OF TURKU   (Finland)

Author keywords

Autoimmunity; Collagen induced arthritis; Rheumatoid arthritis; T cell tolerance; Transgenic mice

Indexed keywords

COLLAGEN TYPE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; AUTOIMMUNITY; CARTILAGE; CELL SPECIFICITY; CONTROLLED STUDY; CROSS REACTION; GENE EXPRESSION; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; ARTHRITIS, EXPERIMENTAL; ASPARTIC ACID; CARTILAGE; CELLS, CULTURED; COLLAGEN; DISEASE SUSCEPTIBILITY; EPITOPES; GLUTAMIC ACID; IMMUNE TOLERANCE; INTERFERON TYPE II; LYMPH NODES; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C3H; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; ORGAN SPECIFICITY; POINT MUTATION; POLYMERASE CHAIN REACTION; RATS; T-LYMPHOCYTES; TIME FACTORS;

ANIMALIA; MUS MUSCULUS;

EID: 0030006224     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.9.4480     Document Type: Article

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