The production of two Th2 cytokines interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively

Immunogenetics

Volumn 49, Issue 2, 1999, Pages 134-141

  Kosařová, Marcela ^a   Havelková, Helena ^a   Krulová, Magdaléna ^a   Demant, Peter ^b   Lipoldová, Marie ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Gene; Interleukin 10; Interleukin 4; Production; Regulation

Indexed keywords

CONCANAVALIN A; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 4;

ANIMAL CELL; ARTICLE; CHROMOSOME 1; CHROMOSOME 16; CHROMOSOME 5; CYTOKINE PRODUCTION; GENOTYPE; HELPER CELL; IMMUNOGENETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; CHROMOSOME MAPPING; CROSSES, GENETIC; FEMALE; GENE EXPRESSION REGULATION; GENETIC MARKERS; GENOTYPE; INTERLEUKIN-10; INTERLEUKIN-4; LINKAGE (GENETICS); MALE; MICE; MICE, CONGENIC; MICE, INBRED BALB C; TH2 CELLS;

ANIMALIA; ANTHOZOA;

EID: 0032927522     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002510050472     Document Type: Article

References (38)

1. Allen, J.E. and Maizels, R.M. Th1-Th2: reliable paradigm or dangerous dogma? Immunol Today 18: 387-392, 1997
2. Almawi, W.Y., Beyhum, H.N., Rahme, A.A., and Rieder, M.J. Regulation of cytokine and cytokine receptor expression by glukokorticoids. J Leukoc Biol 60: 563-572, 1996
3. Biron, C. A. Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr Opin Immunol 6: 530-538, 1994
4. Bonomo, A., Kehn, P.J., Payer, E., Rizzo, L., Cheever, A.W., and Shevach, E.M. Pathogenesis of post-thymectomy autoimmunity. Role of syngeneic MLR-reactive T cells. J Immunol 154: 6602-6611, 1995
5. Bucy, R.P., Panoskaltis-Mortari, A., Huang, G.-q., Li, J., Karr, L., Ross, M., Russell, J.H., Murphy, K.M., Weaver, C.T. Heterogeneity of single cell cytokine gene expression in clonal T cell populations. J Exp Med 180: 1251-1262, 1994
6. Charlton, B. and Lafferty, K.J. The Th1/Th2 balance in autoimmunity. Curr Opin Immunol 7: 793-798, 1995
7. Demant, P. Genetic resolution of susceptibility to cancer - new perspectives. Sem Cancer Biol 3: 159-166, 1992
8. Demant, P. and Hart, A.A.M. Recombinant congenic strains: a new tool for analyzing genetic traits determined by more than one gene. Immunogenetics 24: 416-422, 1986
9. Demant, P. Lipoldová, M., and Svobodová, M. Resistance to Leishmania major in mice. (Technical comment) Science 274: 1392, 1996
10. Dietrich, W., Katz, H., Lincoln, S.E., Shin, H.-S., Friedman, J., Dracopoli, N.C., and Lander, E.S. A genetic map of the mouse suitable for typing interspecific crosses. Genetics 131: 423-447, 1992
11. Exley, M., Varticovski, L., Peter, M., Sancho, J., and Terhorst, C. Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation. J Biol Chem 269: 15140-15146, 1994
12. Fijneman, R.J.A., de Vries, S.S., Jansen, R.C., and Demant, P. Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3 and Sluc4, that influence susceptibility to lung cancer in the mouse. Nature Genet 14: 465-467, 1996
13. Gorham J.D., Güler M.L., Steen R.G., Mackey R.J., Daly M.I., Frederick K., Dietrich W.F., Murphy K.M. Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses. Proc Natl Acad Sci USA 93: 12467-12472, 1996
14. Havelková, H., Krulová, M., Kosařová, M., Holáň, V., Hart, A.A.M., Demant, P., and Lipoldová, M. Genetic control of T-cell proliferative response in mice linked to chromosomes 11 and 15. Immuno genetics 44: 475-477, 1996
15. Holáň, V., Lipoldová, M., and Demant, P. Identical genetic control of MLC reactivity to different MHC incompatibilities, independent of production and response to IL-2. Immunogenetics 44: 27-35, 1996
16. Kelso, A. Th1 and Th2 subsets: Paradigms lost? Immunol Today 16: 374-379, 1995
17. Krulová, M., Havelková, H., Kosařová, M., Holáň, V., Hart, A.A.M., Demant, P., and Lipoldová, M. IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12. A distinct control of the response induced by different IL-2 concentrations. Genomics 42: 11-15, 1997
18. Laird, P., Zijderveld, A., Linders, K., Rudnicky, M. A., Jaenisch, R., and Berns, A. Simplified mammalian DNA isolation procedure. Nucleic Acids Res 19: 4293, 1991
19. Lander, E.S., and Schork, N.J. Genetic dissection of complex traits. Science 265: 2037-2048, 1994
20. Lee, G.H., Benett, L.M., Carabeo, R.A., and Drinkwater, N.R. Identification of hepatocarcinogen resistance genes in DBA/2 mice. Genetics 193: 387-395, 1995
21. Lipoldová, M., Kosařová, M., Zajícová, A., Holáň, V., Hart, A.A.M., Krulová, M., and Demant, P. Separation of multiple genes controlling the T-cell proliferative response to IL-2 and anti-CD3 using recombinant congenic strains. Immunogenetics 41: 301-311, 1995
22. Mobraaten, L.E., Bunker, H.P., DeMaeyer-Guignard, J., DeMaeyer, E., and Bailey, D.W. Location of histocompatibility and Interferon loci on chromosome 3 of the mouse. J Hered 75: 233-234, 1984
23. Moen, C.J.A., Groot, P.C., Hart, A.A.M., Snoek, M. and Demant, P. Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer. Proc Natl Acad Sci USA 93: 1082-1086, 1996
24. Moen, C.J.A., van der Valk M.A., Snoek M., van Zutphen, L.F.M., von Deimling, O., and Demant, P. The recombinant congenic strains: a novel genetic tool applied to the study of colon tumor development in the mouse. Mamm Genome 1: 217-227, 1991
25. Moore, K.W., O'Garra, A., de Waal Malefyt, R., Vieira, P., and Mosmann, T.R. Interleukin-10. Annu Rev Immunol 11: 165-190, 1993
26. Mosmann, T.R., Cherwinski, H., Bond, M.W., Giedlin, M.A., and Coffman, R.L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348-2357, 1986
27. Mosmann, T. R. and Sad, S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17: 138-146, 1996
28. + T cell subset activation. J Exp Med 170: 2135-2140, 1989
29. Paul, W.E. Interleukin-4 : a prototypic immunoregulatory lymphokine. Blood 77: 1859-1890, 1991
30. Piccinni, M. P., Beloni, L., Giannarini, L., Livi, C., Scarselli, G., Romagnani, S., and Maggi, E. Abnormal production of T helper 2 cytokines interleukin-4 and interleukin-5 by T cells from newborns with atopic parents. Eur J Immunol 26: 2293-2298, 1996
31. Preisler, H.D., Bi, S., Venugopal, P., and Raza, A. Cytokines, molecular biological abnormalities, and acute myelogenous leukemia. Leuk Res 21: 299-312, 1997
32. Raj, N.B.K., Cheung, S.C., Rosztoczy, I., and Pitha, P.M. Mouse genotype affects inducible expression of cytokine genes. J Immunol 148: 1934-1940, 1992
33. Sher, A. and Coffman, R.L. Regulation of immunity to parasites by T cell-derived cytokines. Annu Rev Immunol 10: 385-409, 1992
34. Stassen, A.P.M., Groot, P.C., Eppig, J.T., and Demant, P. Genetic composition of the recombinant congenic strains. Mamm Genome 7: 55-58, 1996
35. Strieter, R.M., Polverini, P.J., Arenberg, D.A., Walz, A., Opdenakker, G., Van Damme, J., and Kunkel, S.L. Role of C-X-C chemokines as regulators of angiogenesis in lung cancer. J Leukoc Biol 57: 752-762, 1995
36. Van Wezel, T., Stassen, A. P.M., Moen, C.J.A., Hart, A.A.M., van der Valk, M.A, and Demant, P. Gene interaction and single gene effects in colon tumor susceptibility in mice. Nature Genet 14: 468-470, 1996
37. Wardell, B.B., Michael, S.D., Tung, K.S.K., Todd, J.A., Blenkenhorn, E.P., McEntee, K., Sudweeks, J.D., Hansen, W.K., Meeker, N.D., Griffith, J.S., Livingstone, K.D., and Teuscher, C. Aod1, the immunoregulatory locus controlling abrogation of tolerance in neonatal thymectomy-induced autoimmune ovarian dysgenesis, maps to mouse chromosome 16. Proc Natl Acad Sci USA 92: 4758-4762, 1995
38. Weaver, C.T., Hawrylovicz, C.M., and Unanue, E.R. T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells. Proc Natl Acad Sci USA 85: 8181-8185, 1988