Effects of tyrosine kinase inhibitors on tyrosine phosphorylations and the insulin-like effects in response to human growth hormone in isolated rat adipocytes

Endocrinology

Volumn 137, Issue 11, 1996, Pages 4650-4656

  Ridderstråle, Martin ^a,b   Tornqvist, Hans ^b,c  

^a Section for Molecular Signalling   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c HAGEDORN RESEARCH INSTITUTE   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CALPHOSTIN C; CINNAMIC ACID; HERBIMYCIN A; HUMAN GROWTH HORMONE; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; STAUROSPORINE; TYRPHOSTIN;

ADIPOCYTE; ADOLESCENT; ANIMAL CELL; ARTICLE; HORMONE ACTION; INSULIN LIKE ACTIVITY; LIPOGENESIS; LIPOLYSIS; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

EID: 0029827091     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.11.8895329     Document Type: Article

References (39)

1. Roupas P, Herington AC 1994 Postreceptor signaling mechanisms for growth hormone. Trends Endocrinol Metab 5:114-118
2. Goodman HM 1968 Growth hormone and the metabolism of carbohydrate and lipid in adipose tissue. Ann NY Acad Sci 148:441
3. Ailhaud G, Grimaldi P, Negrel R 1994 Hormonal regulation of adipose differentiation. Trends Endocrinol Metab 5:132-136
4. Wabitsch M, Heinze E, Hauner H, Shymko RM, Teller WM, De Meyts P, Ilondo MM 1996 Biological effects of human growth hormone in rat adipocyte precursor cells and newly differentiated adipocytes in primary culture. Metabolism 45:34-42
5. Davidson M 1987 Effect of growth hormone on carbohydrate and lipid metabolism. Endocr Rev 8:115-131
6. Goodman HM 1981 Separation of early and late responses of adipose tissue to growth hormone. Endocrinology 109:120-129
7. Edén S, Schwartz J, Kostyo JL 1982 Effects of preincubation on the ability of rat adipocytes to bind and respond to growth hormone. Endocrinology 111:1505-1512
8. Goodman HM, Coiro V 1981 Induction of sensitivity to the insulin-like action of growth hormone in normal rat adipose tissue. Endocrinology 108:113-118
9. Fain JN 1967 Studies on the role of RNA and protein synthesis in the lipolytic action of growth hormone in isolated fat cells. In: Weber G (ed) Advances in Enzyme Regulation. Pergamon Press, Oxford, pp 39-51
10. Cunningham BC, Ultsch M, Devos AM, Mulkerrin MG, Clauser KR, Wells JA 1991 Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science 254:821-825
11. Ilondo MM, Damholt AB, Cunningham BA, Wells JA, De Meyts P, Shymko RM 1994 Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes. Endocrinology 134:2397-2403
12. Argetsinger LS, Campbell GS, Yang X, Silvennoinen O, Ihle JN, Carter-Su C 1993 Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 74:237-244
13. Eriksson H, Ridderstråle M, Tornqvist H 1995 Tyrosine phosphorylation of the growth hormone (GH) receptor and Janus tyrosine kinase 2 is involved in the insulin-like actions of GH in primary rat adipocytes. Endocrinology 136:5093-5101
14. Meyer DJ, Campbell GS, Cochran BH, Argetsinger LS, Lamer AC, Finbloom DS, Carter-Su C, Schwartz J 1994 Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factor. J Biol Chem 269:4701-4704
15. Campbell GS, Pang L, Miyasaka T, Saltiel AR, Carter-Su C 1992 Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblasts. J Biol Chem 267:6074-6080
16. Ridderstrale M, Degerman E, Tomqvist H 1995 Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phospharidylinositol 3-kinase in primary adipocytes. J Biol Chem 270:3471-3474
17. Souza SC, Frick GP, Yip R, Lobo RB, Tai LR, Goodman HM 1994 Growth hormone stimulates tyrosine phosphorylation of insulin receptor substrate-1. J Biol Chem 269:30085-30088
18. Ridderatråle M, Tomqvist H 1994 PI-3-kinase inhibitor wortmannin blocks the insulin-like effects of growth hormone in isolated rat adipocytes. Biochem Biophys Res Commun 203:306-310
19. Rahn T, Ridderstråle M, Tornqvist H, Manganiello V, Fredrikson G, Belfrage P, Degerman E 1994 Essential role of phosphatidylinositol 3-kinase in insulin-induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes-studies using the selective inhibitor wortmannin. FEBS Lett 350:314-318
20. Gazit A, Yaish P, Gilon C, Levitzki A 1989 Tyrphostins. I. Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 2344-2352
21. Levitzki A, Gazit A 1995 Tyrosine kinase inhibition: an approach to drug development. Science 267:1782-1788
22. Rodbell M 1964 Metabolism of isolated fat cells. 1. Effects of hormones on glucose metabolism and lipolysis. J Biol Chem 239:375-380
23. Moody AJ, Stan MA, Stan M, Glieman J 1974 A simple free fat cell bioassay for insulin. Horm Metab Res 6:12-16
24. Hansen BF, Danielsen GM, Drejer K, Sørensen AR, Wiberg FC, Klein HH, Lundemose AG 1996 Sustained signaling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency. Biochem J 315:271-279
25. Honnor RC, Dhillon GS, Londos C 1985 cAMP-dependent protein kinase and lipolysis in rat adipocytes. J Biol Chem 260:15122-15129
26. Garland PB, Randle PJ 1962 A rapid enzymatic assay for glycerol. Nature 196:987-988
27. Grichting G, Levy LK, Goodman HM 1983 Relationship between binding and biological effects of human growth hormone in rat adipocytes. Endocrinology 113:1111-1120
28. Kobayashi E, Nakano H, Morimoto M, Tamaoki T 1989 Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 159:548-553
29. Young SW, Poole RC, Hudson AT, Halestrap AP, Denton RM, Tavaré JM 1993 Effects of tyrosine kinase inhibitors on protein kinase-independent systems. FEBS Lett 316:278-282
30. Wang X, Bixiong X, Souza SC, Kopchick JJ 1991 Growth hormone (GH) induces ryrosine-phosphorylated proteins in mouse L cells that express recombinanat GH receptors. Proc Natl Acad Sci USA 91:1391-1395
31. Anderson NG 1992 Growth hormone activates mitogen-activated protein ki-nase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes. Biochem J 284:649-652
32. ++ -dependent protein kinase. Biochem Biophys Res Commun 135:397-402
33. Smal J, De Meyts P 1989 Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes. Proc Natl Acad Sci USA 86:4705-4709
34. Eriksson H, Sundler R, Donnér J 1990 Growth hormone increases phosphoinositide turnover in rat adipocytes that are sensitive to the insulin-like action of the hormone. Mol Cell Biochem 97:181-186
35. Halestrap AP, Denton RM 1975 The specificity and metabolic implications of the inhibition of pyruvate transport in isolated mitochondria and intact tissue preparations by alfa-cyano-4-hydroxycinnamate and related compounds. Biochem J 148:97-106
36. Campbell GS, Christian LJ, Carter-Su C 1993 Evidence for involvement of the growth hormone receptor-associated tyrosine kinase in actions of growth hormone. J Biol Chem 286:7427-7434
37. Shechter Y, Yaish P, Chorev M, Gilon C, Braun S, Levitzki A 1989 Inhibition of insulin-dependent lipogenesis and anti-lipolysis by protein tyrosine kinase inhibitors. EMBO J 8:1617-1676
38. Lyall RM, Zilberstein A, Gazit A, Gilon C, Levitzki A, Schlessinger J 1989 Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J Biol Chem 264:14503-14509
39. June CH, Fletcher MC, Ledbetter JA, Schieven GL, Siegel JN, Phillips AF, Samelson LE 1990 Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction. Proc Natl Acad Sci USA 87:7722-7726