Contextual effects of transforming growth factor β on the tumorigenicity of human colon carcinoma cells

Cancer Research

Volumn 59, Issue 18, 1999, Pages 4725-4731

  Ye, Sheng Chun ^a   Foster, Jason M ^b   Li, WenHui ^a,c   Liang, JiuRong ^a   Zborowska, Elizabeth ^b   Venkateswarlu, Srinivas ^a,c   Gong, JianGen ^a   Brattain, Michael G ^a,c   Willson, James K V ^b  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ISOPROTEIN; RECEPTOR SUBTYPE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CARCINOGENICITY; COLON CARCINOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; DNA TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0033568528     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Lyons, R. M., and Moses, H. L. Transforming growth factors and the regulation of cell proliferation. Eur. J. Biochem., 187: 467-473, 1990.
2. Massagué, J. The transforming growth factor-β family. Annu. Rev. Cell Biol., 6: 597-641, 1990.
3. Roberts, A. B., and Sporn, M. B. The transforming growth factor-βs. In: M. B. Sporn and A. B. Roberts (eds.), Peptide Growth Factors and Their Receptors, pp. 421-472. Heidelberg: Springer-Verlag, 1990.
4. Massagué, J., Cheifetz, S., Boyd, F. T., and Andres, J. L. TGFβ receptors and TGFβ binding proteoglycans: recent progress in identifying their functional properties. Ann. NY Acad. Sci., 593: 59-72, 1990.
5. Bassing, C. H., Yingling, J. M., Howe, D. J., Wang, T., He, W. W., Gustafson, M. L., Shah, P., Donahoe, K., and Wang, X. F. A transforming growth factor-β type I receptor that signals to activate gene expression. Science (Washington DC), 263: 87-89, 1994.
6. Franzen, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schulz, P., Heldin, C. H., and Miyazono, K. Cloning of a TGFβ type 1 receptor that forms a heteromeric complex with the TGFβ type II receptor. 75: 681-692, 1993.
7. Vivien, D., Attisano, L., Wrana, J. L., and Massagué, J. Signaling activity of homologous and heterologous transforming growth factor-β receptor kinase complexes. J. Biol. Chem., 270: 7134-7141, 1995.
8. Wrana, J. L., Attisano, L., Carcamo, J., Zentella, A., Doody, J., Laiho, M., Wang, X. F., and Massagué, J. TGFβ signals through a heteromeric protein kinase receptor complex. Cell, 71: 1003-1014, 1992.
9. Derynck, R., Goeddel, D. V., Ullrich, A., Gutterman, J. U., Williams, R. D., Bringman, T. S., and Berger, W. H. Synthesis of messenger RNAs for transforming growth factors-α and β and the epidermal growth factor receptor by human tumors and β1 in renal cell carcinoma. Cancer Res., 47: 707-712, 1987.
10. Gomella, L. G., Sargent, E. R., Wade, T. P., Anglard, P., Linehan, W. M., and Kasid, A. Expression of transforming growth factor-α in normal human adult kidney and enhanced expression of transforming growth factors-α and β1 in renal cell carcinoma. Cancer Res., 49: 6972-6975, 1989.
11. Ito, N., Kawata, S., Tamura, S., Takaishi, K., Shirai, Y., Kiso, S., Yabuuchi, I., Matsuda, Y., Nishioka, M., and Tarui, S. Elevated levels of transforming growth factor-β messenger RNA and its polypeptide in human hepatocellular carcinoma. Cancer Res., 51: 4080-4083, 1991.
12. Mon, H., Maki, M., Oishi, K., Jaye, M., Igarashi, K., Yoshida, O., and Hatanaka, M. Increased expression of genes for basic fibroblast growth factor and transforming growth factor type-β2 in human benign prostatic hyperplasia. Prostate, 16: 71-80, 1990.
13. Murphy, C. S., Pietenpol, J. A., Munger, K., Howley, P. M., and Moses, H. L. c-myc and pRb: role in TGFβ1 inhibition of keratinocyte proliferation. Cold Spring Harbor Symp. Quant. Biol., 56: 129-135, 1991.
14. Niitsu, Y., Urushizaki, Y., Koshida, Y., Terui, K., Mahara, K., Kohgo, Y., and Urushizaki, I. Expression of TGFβ gene in adult T cell leukemia. Blood, 71: 263-266, 1988.
15. Travers, M. T., Barrett-Lee, P. J., Burger, U., Luqmani, Y. A., Gazet, J. C., Powles, T. J., and Coombes, R. C. Growth factor expression in normal, benign, and malignant breast tissue. Br. Med. J. Clin. Res. Ed., 296: 1621-1624, 1988.
16. Arrik, B., Lopez, A., Elfman, F., Ebner, R., Damsky, C., and Derynck, R. Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor-β1. J. Cell Biol., 118: 715-726, 1992.
17. Chang, H., Gillett, N., Figari, I., Lopez, A., Palladino, M., and Derynck, R. Increased transforming growth factor-β expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells. Cancer Res., 53: 4391-4398, 1993.
18. Steiner, M., and Barrak, E. Transforming growth factor-β1 overproduction in prostate cancer: effects on growth in vivo and in vitro. Mol. Endocrinol., 6: 15-25, 1992.
19. Wu, S. P., Sun, L. Z., Willson, J. K., Humphrey, L., Kerbel, K., and Bratlain, M. G. Repression of autocrine transforming growth factor-β1 and β2 in quiescent CBS colon carcinoma cells leads to progression of tumorigenic properties. Cell Growth Differ., 4: 115-123, 1993.
20. Wu, S. P., Theodorescu, D., Kerbel, R. S., Willson, J. K., Mulder, K. M., Humphrey, L. E., and Brattain, M. G. TGFβ1 is an autocrine-negative growth regulator of human colon carcinoma FET cells in vivo as revealed by transfection of an antisense expression vector. J. Cell Biol., 116: 187-196, 1992.
21. Kadin, M. E., Cavaille-Coll, M. W., Gertz, R., Massagué, J., Cheifetz, S., and George, D. Loss of receptors for transforming growth factor β in human T-cell malignancies. Proc. Natl. Acad. Sci. USA, 91: 6002-6006, 1994.
22. Knaus, P. I., Lindemann, D., DeCoteau, J. F., Perlman, R., Yankelev, H., Hille, M., Kadin, M. E., and Lodish, H. F. A dominant inhibitory mutant of the type II transforming growth factor-β receptor in the malignant progression of a cutaneous T-cell lymphoma. Mol. Cell. Biol., 16: 3480-3489, 1996.
23. Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., Brattain, M. G., and Willson, J. K. V. Inactivation of the type II TGFβ receptor in colon cancer cells with microsatellite instability. Science (Washington DC), 268: 1336-1338, 1995.
24. Sun, L., Wu, S., Coleman, K., Fields, K. C., Humphrey, L. E., and Brattain, M. G. Autocrine transforming growth factor-β1 and β2 expression is increased by cell crowding and quiescence in colon carcinoma cells. Exp. Cell Res., 214: 215-224, 1994.
25. Park, K., Kim, S. J., Bang, Y. J., Park, J. G., Kim, N. K., Roberts, A. B., and Sporn, M. B. Genetic changes in the transforming growth factor-β (TGFβ) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGFβ. Proc. Natl. Acad. Sci. USA, 91: 8772-8776, 1994.
26. Arteaga, C. L., Tandon, A. K., Von Hoff, D. D., and Osborne, C. K. Transforming growth factor-β: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells. Cancer Res., 48: 3898-3904, 1988.
27. Hoosein, N. M., McKnight, M. K., Levine, A. E., Mulder, K. M., Childress, K. E., Brattain, D. E., and Brattain, M. G. Differential sensitivity of subclasses of human colon carcinoma cell lines to the growth inhibitory effects of transforming growth factor-β1. Exp. Cell Res., 181: 442-453, 1989.
28. Manning, A. M., Williams, A. C., Game, S. M., and Paraskeva, C. Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor-β (TGFβ): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGFβ. Oncogene, 6: 1471-1476, 1991.
29. Sun, L-Z., Wu, G., Willson, J. K. V., Yang, J-H., Rajakarunanyke, I., Wang, J., Gentry, L. E., Wang, X. F., and Brattain, M. G. Expression of transforming growth factor-β type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. J. Biol. Chem., 269: 26449-26455, 1994.
30. Wang, J., Sun, L., Myeroff, L., Wang, X., Gentry, L. E., Yang, J., Liang, J., Zborowska, E., Markowitz, S., Willson, J. K., and Brattain, M. G. Demonstration that mutation of the type II transforming growth factor-β receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. J. Biol. Chem., 270: 22044-22049, 1995.
31. Jiang, D., Yang, H., Willson, J. K. V., Liang, J., Humphrey, L. E., Zborowska, E., Wang, D., Foster, J., Fan, R., and Brattain, M. G. Autocrine TGFα provides a growth advantage to malignant cells by facilitating re-entry into the cell cycle from suboptimal growth states. J. Biol. Chem., 273: 31471-31479, 1998.
32. Brattain, M. G., Levine, A. E., Chakrabarty, S., Yeoman, L. C., Willson, J. K., and Long, B. Heterogeneity of human colon carcinoma. Cancer Metastasis Rev., 3: 177-197, 1984.
33. Boyd, D. D., Levine, A. E., Brattain, D. E., McKnight, M. K., and Brattain, M. G. Comparison of growth requirements of two human intratumoral colon carcinoma cell lines in monolayer and soft agarose. Cancer Res., 48: 2469-2474, 1988.
34. Mulder, K. M., and Brattain, M. G. Effects of growth stimulatory factors on mitogenicity and c-myc expression in poorly differentiated and well differentiated human colon carcinoma cells. Mol. Endocrinol., 3: 1215-1222, 1989.
35. Gossen, M., and Bujard, H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA, 89: 5547-5551, 1992.
36. Koli, K. M., Ramsey, T. T., Ko, Y., Dugger, T. C., Brattain, M. G., and Arteaga, C. L. Blockade of transforming growth factor-β signaling does not abrogate antiestrogen-induced growth inhibition of human breast carcinoma cells. J. Biol. Chem., 272: 8296-8302, 1997.
37. Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J., and Rutter W. J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry, 18: 5294-5299, 1979.
38. Ruff, E., and Rizzino, A. Preparation and binding of radioactively labeled porcine transforming growth factor type-β. Biochem. Biophys. Res. Commun., 138: 714-719, 1986.
39. Segarini, P., Roberts, A., Rosen, D., and Seyedin, S. Membrane binding characteristics of two forms of transforming growth factor-β. J. Biol. Chem., 262: 14655-14662, 1987.
40. Sambrook, J., Fritsch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
41. Yang, E. Y., and Moses, H. L. Transforming growth factor-β1-induced changes in cell migration, proliferation, and angiogenesis in chicken chorialloantoic membrane. J. Cell Biol., 111: 731-741, 1990.
42. Higashino, K. Potentiation of metastatic capacity by transforming growth factor-β1 gene transfection. Jpn. J. Cancer Res., 84: 589-593, 1993.
43. Mukai, M., Shinkai, K., Komatsu, K., and Akedo, H. Potentiation of invasive capacity of rat ascites hepatoma cells by transforming growth factor-β. Jpn J Cancer Res., 80: 107-110, 1989.
44. Kehrl, J. H., Roberts, A. B., Wakefield, L. M., Jakowlew, S., Sporn, M. B., and Fauci, A. S. Transforming growth factor-β is an important immunomodulatory protein for human B lymphocytes. J. Immunol., 137: 3855-3860, 1986.
45. Ruscetti, F., Varesio, L., Ochoa, A., and Ortaldo, J. Pleiotropic effects of transforming growth factor-β on cells of the immune system. Ann. NY Acad. Sci., 685: 488-500, 1993.
46. Ruscetti, F. W., and Palladino, M. A. Transforming growth factor-β and the immune system. Prog. Growth Factor Res., 3: 159-175, 1991.
47. Sosroseno, W., and Herminajeng, E. The immunoregulatory roles of transforming growth factor-β. Br. J. Biomed. Sci., 52: 142-148, 1995.
48. Wallick, S., Figari, I., Morris, R., Levinson, A., and Palladino, M. Immunoregulatory role of transforming growth factor β(TGFβ) in development of killer cells: comparison of active and latent TGFβ1. J. Exp. Med., 172: 1777-1784, 1990.
49. Chen, C., Wang, X-F., and Sun, L. Expression of transforming growth factor β type III receptor restores autocrine TGFβ1 activity in human breast cancer MCF-7 cells. J. Biol. Chem., 272: 12862-12867, 1997.