Nonproliferating bystander CD4+ T cells lacking activation markers support HIV replication during immune activation

Journal of Immunology

Volumn 166, Issue 10, 2001, Pages 6437-6443

  Scales, David ^a   Ni, Houping ^a   Shaheen, Farida ^a   Capodici, John ^a   Cannon, Georgetta ^a   Weissman, Drew ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; LYMPHOCYTE SURFACE MARKER;

ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; LYMPHOID ORGAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS REPLICATION;

EID: 0035873713     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.10.6437     Document Type: Article

References (71)

1. Spina, C. A., J. C. Guatelli, and D. D. Richman. 1995. Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro. J. Virol. 69:2977.
2. Stevenson, M., T. L. Stanwick, M. P. Dempsey, and C. A. Lamonica. 1990. HIV-1 replication is controlled at the level of T cell activation and proviral integration. EMBO J. 9:1551.
3. Zack, J. A., A. M. Haislip, P. Krogstad, and I. S. Chen. 1992. Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle. J. Virol. 66:1717.
4. Bukrinsky, M. I., T. L. Stanwick, M. P. Dempsey, and M. Stevenson. 1991. Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection. Science 254:423.
5. Zack, J. A., S. J. Arrigo, S. R. Weitsman, A. S. Go, A. Haislip, and I. S. Chen. 1990. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61:213.
6. Embretson, J., M. Zupancic, J. L. Ribas, A. Burke, P. Racz, K. Tenner-Racz, and A. T. Haase. 1993. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362:359.
7. Pantaleo, G., C. Graziosi, J. F. Demarest, L. Butini, M. Montroni, C. H. Fox, J. M. Orenstein, D. P. Kotler, and A. S. Fauci. 1993. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362:355.
8. Weissman, D., A. Rubbert, C. Combadiere, P. M. Murphy, and A. S. Fauci. 1997. Dendritic cells express and use multiple HIV coreceptors. Adv. Exp. Med Biol. 417:401.
9. + T cell suppressor activities: dichotomy between infected and uninfected individuals, evolution with progression of disease, and sensitivity to γ irradiation. J. Immunol. 156:4476.
10. Pope, M., M. G. Betjes, N. Romani, H. Hirmand, P. U. Cameron, L. Hoffman, S. Gezelter, G. Schuler, and R. M. Steinman. 1994. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell 78:389.
11. Pope, M., M. G. Betjes, H. Hirmand, L. Huffman, and R. M. Steinman. 1995. Both dendritic cells and memory T lymphocytes emigrate from organ cultures of human skin and form distinctive dendritic-T-cell conjugates. J. Invest. Dermatol. 104:11.
12. + T cells. J. Immunol. 155:4111.
13. + T cells is markedly enhanced in the setting of antigen-specific immune activation. J. Exp. Med. 183:687.
14. Weissman, D., J. Daucher, T. Barker, J. Adelsberger, M. Baseler, and A. S. Fauci. 1996. Cytokine regulation of HIV replication induced by dendritic cell-CD4-positive T cell interactions. AIDS Res. Hum. Retroviruses 12:759.
15. Tsunetsugu-Yokota, Y., T. Kato, S. Yasuda, Z. Matsuda, Y. Suzuki, Y. Koyanagi, N. Yamamoto, K. Akagawa, M. W. Cho, and T. Takemori. 2000. Transcriptional regulation of HIV-1 LTR during antigen-dependent activation of primary T cells by dendritic cells. J. Leukocyte Biol. 67:432.
16. Claydon, E. J., J. Bennett, D. Gor, and S. M. Forster. 1991. Transient elevation of serum HIV antigen levels associated with intercurrent infection. AIDS 5:113.
17. Fultz, P. N., J. C. Gluckman, E. Muchmore, and M. Girard. 1992. Transient increases in numbers of infectious cells in an HIV-infected chimpanzee following immune stimulation. AIDS Res. Hum. Retroviruses 8:313.
18. Goletti, D., D. Weissman, R. W. Jackson, N. M. Graham, D. Vlahov, R. S. Klein, S. S. Munsiff, L. Ortona, R. Cauda, and A. S. Fauci. 1996. Effect of Mycobacterium tuberculosis on HIV replication: role of immune activation. J. Immunol. 157:1271.
19. O'Brien, W. A., K. Grovit-Ferbas, A Namazi, S. Ovcak-Derzic, H. J. Wang, J. Park, C. Yeramian, S. H. Mao, and J. A. Zack. 1995. Human immunodeficiency virus-type 1 replication can be increased in peripheral blood of seropositive patients after influenza vaccination. Blood 86:1082.
20. Nakata, K., W. N. Rom, Y. Honda, R. Condos, S. Kanegasaki, Y. Cao, and M. Weiden. 1997. Mycobacterium tuberculosis enhances human immunodeficiency virus-1 replication in the lung. Am. J. Respir. Crit. Care Med. 155:996.
21. Ostrowski, M. A., S. K. Stanley, J. S. Justement, K. Gantt, D. Goletti, and A. S. Fauci. 1997. Increased in vitro tetanus-induced production of HIV type 1 following in vivo immunization of HIV type 1-infected individuals with tetanus toxoid. AIDS Res. Hum. Retroviruses 13:473.
22. Pierson, T., J. McArthur, and R. F. Siliciano. 2000. Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy. Annu. Rev. Immunol. 18:665.
23. Tough, D. F., P. Borrow, and J. Sprent. 1996. Induction of bystander T cell proliferation by viruses and type 1 interferon in vivo. Science 272:1947.
24. + T cells in respiratory virus infections. J. Immunol. 154:6013.
25. + T cells in vivo. J. Immunol. 154:5684.
26. Zarozinski, C. C., and R. M. Welsh. 1997. Minimal bystander activation of CD8 T cells during the virus-induced polyclonal T cell response. J. Exp. Med. 185: 1629.
27. + T cells during an acute virus infection. Immunity 8:167.
28. Murali-Krishna, K., J. D. Altman, M. Suresh, D. Sourdive, A. Zajac, and R. Ahmed. 1998. In vivo dynamics of anti-viral CD8 T cell responses to different epitopes: an evaluation of bystander activation in primary and secondary responses to viral infection. Adv. Exp. Med. Biol. 452:123.
29. Armant, M., R. Armitage, N. Boiani, G. Delespesse, and M. Sarfati. 1996. Functional CD40 ligand expression on T lymphocytes in the absence of T cell receptor engagement: involvement in interleukin-2-induced interleukin-12 and interferon-γ production. Eur. J. Immunol. 26:1430.
30. Rott, O., K. Mignon-Godefroy, B. Fleischer, J. Charreire, and E. Cash. 1995. Superantigens induce primary T cell responses to soluble autoantigens by a non-Vβ-specific mechanism of bystander activation. Cell. Immunol. 161:158.
31. + T cells accounts for herpetic ocular lesions. Invest. Ophthalmot Vis. Sci. 41:453.
32. Abrignani, S. 1997. Bystander activation by cytokines of intrahepatic T cells in chronic viral hepatitis. Semin. Liver Dis. 17:319.
33. Horwitz, M. S., L. M. Bradley, J. Harbertson, T. Krahl, J. Lee, and N. Sarvetnick. 1998. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat. Med. 4:781.
34. Kurane, I., A. L. Rothman, P. G. Livingston, S. Green, S. J. Gagnon, J. Janus, B. L. Innis, S. Nimmannitya, A. Nisalak, and F. A. Ennis. 1994. Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock syndrome. Arch. Virol. 9(Suppl.):59.
35. Fleischer, B. 1994. Superantigens. Apmis 102:3.
36. Blackman, M. A., and D. L. Woodland. 1995. In vivo effects of superantigens. Life Sci. 57:1717.
37. Florquin, S., and M. Goldman. 1996. Immunoregulatory mechanisms of T-cell-dependent shock induced by a bacterial superantigen in mice. Infect. Immun. 64:3443.
38. Shoukry, N. H., P. M. Lavoie, J. Thibodeau, S. D'Souza, and R. P. Sekaly. 1997. MHC class II-dependent peptide antigen versus superantigen presentation to T cells. Hum. Immunol. 54:194.
39. lck with CD4 in antigen-specific signal transduction in T cells. Cell 64:511.
40. Heeg, K., and H. Wagner. 1995. Induction of responsiveness in superantigen-induced anergic T cells: role of ligand density and costimulatory signals. J. Immunol. 155:83.
41. Muraille, E., S. Devos, K. Thielemans, J. Urbain, M. Moser, and O. Leo. 1996. Costimulation regulates the kinetics of interleukin-2 response to bacterial superantigens. Immunology 89:245.
42. Gonzalo, J. A., C. Martinez, T. A. Springer, and J. C. Gutierrez-Ramos. 1995. ICAM-1 is required for T cell proliferation but not for anergy or apoptosis induced by Staphylococcus aureus enterotoxin B in vivo. Int. Immunol. 7:1691.
43. + T cells. J. Immunol. 158:637.
44. Chervonsky, A. V., J. Xu, A. K. Barlow, M. Khery, R. A. Flavell, and C. A. Janeway, Jr. 1995. Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV. Immunity 3:139.
45. 7 integrin expression on human activated T lymphocytes. J. Immunol. 156:3668.
46. Maino, V. C., M. A. Suni, and J. J. Ruitenberg. 1995. Rapid flow cytometric method for measuring lymphocyte subset activation. Cytometry 20:127.
47. Kuroda, K., J. Yagi, K. Imanishi, X. J. Yan, X. Y. Li, W. Fujimaki, H. Kato, T. Miyoshi-Akiyuma, Y. Kumazawa, H. Abe, et al. 1996. Implantation of IL-2-containing osmotic pump prolongs the survival of superantigen-reactive T cells expanded in mice injected with bacterial superantigen. J. Immunol. 157:1422.
48. Dannecker, G., U. Mahlknecht, H. Schultz, M. K. Hoffmann, and D. Niethammer. 1994. Activation of human T cells by the superantigen staphylococcus enterotoxin B: analysis on a cellular level. Immunobiology 190:116.
49. Zhou, L. J., R. Schwarting, H. M. Smith, and T. F. Tedder. 1992. A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. J. Immunol. 149:735.
50. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179:1109.
51. Rana, S., G. Besson, D. G. Cook, J. Rucker, R. J. Smyth, Y. Yi, J. D. Turner, H. H. Guo, J. G. Du, S. C Peiper, et al. 1997. Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the δccr5 mutation. J. Virol. 71:3219.
52. Collman, R., J. W. Balliei, S. A. Gregory, H. Friedman, D. L. Kolson, N. Nathanson, and A. Srinivasan. 1992. An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1. J. Virol. 66:7517.
53. Singh, A., G. Besson, A. Mobasher, and R. G. Collman. 1999. Patterns of chemokine receptor fusion cofactor utilization by human immunodeficiency virus type 1 variants from the lungs and blood. J. Virol. 73:6680.
54. Stanley, S., M. A. Ostrowski, J. S. Justement, K. Gantt, S. Hedayati, M. Mannix, K. Roche, D. J. Schwartzentruber, C. H. Fox, and A. S. Fauci. 1996. Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1, N. Engl. J. Med. 334:1222.
55. Chesebro, B., K. Wehrly, J. Nishio, and S. Perryman. 1992. Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism. J. Virol. 66:6547.
56. Gallo, R. C., S. Z. Salahuddin, M. Popovic, G. M. Shearer, M. Kaplan, B. F. Haynes, T. J. Palker, R. Redfield, J. Oleske, B. Safai, et al. 1984. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 224:500.
57. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271.
58. + lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J. Clin. Invest. 103:1391.
59. Andersson, J., T. E. Fehniger, B. K. Patterson, J. Pottage, M. Agnoli, P. Jones, H. Behbahani, and A. Landay. 1998. Early reduction of immune activation in lymphoid tissue following highly active HIV therapy. AIDS 12:F123.
60. Bhardwaj, N., J. W. Young, A. J. Nisanian, J. Baggers, and R. M. Steinman. 1993. Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses. J. Exp. Med. 178:633.
61. Schuler, G., B. Thurner, and N. Romani. 1997. Dendritic cells: from ignored cells to major players in T-cell-mediated immunity. Int. Arch. Allergy Immunol. 112: 317.
62. Weissman, D., and A. S. Fauci. 1997. Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infection. Clin. Microbiol. Rev. 10: 358.
63. Gervois, N., Y. Guilloux, E. Diez, and F. Jotereau. 1996. Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions. J. Exp. Med. 183:2403.
64. + T cells by delivery of the B7 costimulatory signal on bystander antigen-presenting cells (trans-costimulation). Eur. J. Immunol. 24:859.
65. Unutmaz, D., V. N. KewalRamani, S. Marmon, and D. R. Littman. 1999. Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes. J. Exp. Med. 189:1735.
66. + T cells using a combination of cytokines. J. Exp. Med. 188:83.
67. + T cells. Science 286:1353.
68. + T cells. Science 276:273.
69. Bleul, C. C., L. Wu, J. A. Hoxie, T. A. Springer, and C. R. Mackay. 1997. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl. Acad. Sci. USA 94:1925.
70. + lymphocytes in vivo. J. Infect. Dis. 181:933.
71. + T cell proliferation in HIV-positive patients as a result of CD28 costimulation. Science 272:1939.