Bystander activation of CD4+ T cells accounts for herpetic ocular lesions

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 2, 2000, Pages 453-459

  Gangappa, Shivaprakash ^a,b   Deshpande, Shilpa P ^a   Rouse, Barry T ^a,c  

^a UNIVERSITY OF TENNESSEE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; VIRUS ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN RECOGNITION; ARTICLE; EYE INJURY; HELPER CELL; HERPES SIMPLEX; HERPES SIMPLEX KERATITIS; IMMUNOPATHOLOGY; INFECTION RISK; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRANSGENE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CORNEAL STROMA; ENZYME-LINKED IMMUNOSORBENT ASSAY; HERPESVIRUS 1, HUMAN; IMMUNOENZYME TECHNIQUES; IMMUNOGLOBULIN G; INTERFERON TYPE II; KERATITIS, HERPETIC; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MOLECULAR MIMICRY; OVALBUMIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 0033952879     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Pepose JS, Leib DA, Smart PM, Easty DL. Herpes simplex virus disease. Anterior segment of the eye. In: Pepose JS, Holland GN, Wilhelmus KR, eds. Ocular Infection and Immunity. St. Louis, MO: Moshy; 1996:905-929.
2. Russell RG, Nasisse MP, Larsen HS, Rouse BT. Role of T lymphocytes in the pathogenesis of herpetic stromal keratitis. Invest Ophthalmol Vis Sci. 1984;25:938-944.
3. Niemialtowski MG, Rouse BT. Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis. J Immunol. 1992;149: 3035-3039.
4. Hendricks RL, Tumpey TM, Finnegan A. IFN-γ and IL-2 are protective in the skin hut pathologic in the corneas of HSV-1 infected mice. J Immunol. 1992;149:3023-3028.
5. Kanangat S, Thomas J, Gangappa S, Babu JS, Rouse BT. Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. J Immunol. 1996;156:1110-1016.
6. Metcalf J, Hamilton D, Riechart R. Herpetic keratitis in athymic (nude mice). Infect Immun. 1979;26:1164-1171.
7. Mercadel C, Bouley D, DeStephano D, Rouse BT. Herpetic stromal keratitis in the reconstituted SCID mouse model. J Virol. 1993;67: 3404-3408.
8. Avery A, Zhao ZS, Rodriguez E, et al. Resistance to herpes stromal keratitis conferred by an IgG2a derived peptide. Nature, 1995;376: 431-434.
9. Zhao Z, Granucci F, Yeh L, Schaffer P, Cantor H. Molecular mimicry by Herpes simplex virus-type 1: autoimmune disease after viral infection. Science. 1998;279:1344-1347.
10. Hayashi RJ, Loh DY, Kanagawa O, Wang F. Differences between responses of naive and activated T cells to anergy induction. J Immunol. 1998;160:33-38.
11. Newwell CK, Martin S, Sendele D, Mercadel CM, Rouse BT. Herpes simplex virus-induced stromal keratitis: role of T lymphocyte subsets in immunopathology. J Virol. 1989;63:769-775.
12. + T lymphocytes. Invest Ophthalmol Vis Sci. 1992;33:2165-2173.
13. Manickan E, Rouse RJD, Yu Z, Wire WS, Rouse BT. Genetic immunization against herpes simplex virus proliferation is mediated by CD4+ T lymphocytes. J Immunol. 1995;155:259-265.
14. Banks TA, Jenkins FA, Kanangat S, et al. Vaccination with the immediate-early protein ICP47 of herpes virus-specific lymphoproliferation, but fails to protect against lethal challenge. Virology. 1994;200:236-245.
15. Kanangat S, Soloman A, Rouse BT. Use of quantitative polymerase chain reaction to quantitate cytokine messenger RNA molecules. Mol Immunol 1992;29:1229-1235.
16. Spear PG, Roizman B. Proteins specified by herpes simplex virus. V. Purification and structural proteins of the herpes virion. J Virol. 1972;9:143-149.
17. Strelein JW, Reza Dana M, Ksander BR. Immunity causing blindness: five different paths to herpes stromal keratitis. Immunol Today. 1997;9:443-449.
18. Gangappa S, Babu JS, Thomas J, Daheshia M, Rouse BT. Virus-induced immunoinflammatory lesions in the absence of viral antigen recognition. J Immunol. 1998;161:4289-4300.
19. Horwitz MS, Bradley LM, Harbertson J, Krahl T, Lee J, Sarvetnick N. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat Med. 1998;4:781-785.