Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains

Journal of the Neurological Sciences

Volumn 165, Issue 1, 1999, Pages 48-55

  Hulet, S W ^a   Powers, S ^b   Connor, J R ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Ferritin; Ferritin receptor; Multiple sclerosis; Myelination; Oligodendrocytes; Transferrin receptor

Indexed keywords

FERRITIN; TRANSFERRIN;

ARTICLE; CONTROLLED STUDY; DEMYELINATION; DISSOCIATION CONSTANT; GRAY MATTER; HUMAN; HUMAN TISSUE; MULTIPLE SCLEROSIS; MYELINATION; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN BINDING;

ADULT; AUTORADIOGRAPHY; BINDING, COMPETITIVE; BRAIN CHEMISTRY; CORPUS CALLOSUM; FERRITINS; HUMANS; IMMUNOHISTOCHEMISTRY; IODINE RADIOISOTOPES; KINETICS; MEMBRANES; MULTIPLE SCLEROSIS; PROTEIN BINDING; TRANSFERRIN;

EID: 0033137124     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(99)00077-5     Document Type: Article

References (22)

1. Rajan K.S., Colburn R.W., Davis J.M. Distribution of metal ions in the subcellular fractions of several rat brain areas. Life Sci. 18:(4):1976;423-432.
2. Connor J.R. Proteins of iron regulation in the brain in Alzheimer's disease. Lauffer R.B. Iron and human disease. 1992;365-393 CRC Press, Ann Arbor, MI.
3. Eccelston P.A., Silberberg D.H. The differentiation of oligodendrocytes in a serum-free, hormone supplemented medium. Dev. Brain Res. 16:1984;1-9.
4. Lin H.H., Connor J.R. The development of the transferrin-transferrin receptor system in relation to astrocytes, MBP and galactocerebroside in normal and myelin-deficient rat optic nerves. Dev. Brain Res. 49:1989;281-293.
5. Espinosa de los Monteros A., Foucaud B. Effect of iron and transferrin on pure oligodendrocytes in culture: Characterization of high affinity transferrin receptor at different ages. Dev. Brain Res. 35:1987;123-130.
6. Connor J.R., Menzies S.L. Relationship of iron to oligodendrocytes and myelination. Glia. 17:1996;83-93.
7. Morris C.M., Candy J.M., Oakley A.E., Taylor G.A., Mountfort S., Bishop H., Ward M.K., Bloxham C.A., Edwardson J.A. Comparison of the regional distribution of transferrin receptors and aluminum in the forebrain of chronic renal dialysis patients. J. Neurol. Sci. 94:1989;295-306.
8. Hill J.M., Ruff M.R., Weber R.J., Pert C.B. Transferrin receptors in rat brain: Neuropeptide-like pattern and relationship to iron distribution. Proc. Natl. Acad. Sci. USA. 82:1985;4553-4557.
9. Mash D.C., Pablo J., Flynn D.D., Efange S.M.N., Weiner W.J. Characterization and distribution of transferrin receptors in the rat brain. J. Neurochem. 55:(6):1990;1972-1979.
10. Addison G.M., Beamish M.R., Hales C.N., Hodgkins M., Jacobs A., Llewellin P. An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. J. Clin. Path. 25:1972;326-329.
11. Hallgren R., Terent A., Wide L., Bergstrom K., Birgegard G. Cerebrospinal fluid ferritin in patients with cerebral infarction or bleeding. Acta Neurol Scandinav. 61:1980;384-392.
12. Mack U., Powell L.W., Halliday J.W. Detection and isolation of a hepatic membrane receptor for ferritin. J. Biol. Chem. 258:(8):1983;4672-4675.
13. Adams P.C., Powell L.W., Halliday J.W. Isolation of a human hepatic ferritin receptor. Hepatology. 8:(4):1988;719-721.
14. Hulet S.W., Hess E.J., Debinski W., Arosio P., Bruce K., Powers S., Connor J.R. Characterization and distribution of ferritin binding sites in the adult mouse brain. J. Neurochem. 72:1999;868-874.
15. Levi S., Cesarini G., Arosio P., Lorenzetti R., Soria M., Sollazo M., Albertini A., Cortese R. Characterization of human ferritin H chain synthesized in Escherichia Coli. Gene. 51:1987;267-272.
16. Hunter W.M., Greenwood F.C. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature. 194:1962;495-496.
17. Covell A.M., Cook J.D. Stability of radioiodinated ferritin. Clinica Chimica Acta. 168:1987;261-272.
18. Taylor E.M., Morgan E.H. Developmental changes in transferrin and iron uptake by the brain in the rat. Dev. Brain Res. 55:1990;35-42.
19. Jacobsen S. Sequence of myelinization in the brain of the albino rat. A. Cerbral cortex, thalamus and related structures. J. Comp. Neurol. 121:1963;5-29.
20. Larkin E.C., Rao G.A. Importance of fetal and neonatal iron: adequacy for normal development of central nervous system. Dobbing J. Brain, behaviour and iron in the infant diet. 1990;43-63 Springer-Verlag, London.
21. Prineas J.W., Connell F. Remyelination in Multiple Sclerosis. Ann. Neurol. 5:1979;22-31.
22. Prineas J.W., Kwon E.E., Goldenberg P.Z., Ilyas A.A., Quarles R.H., Benjamins J.A., Sprinkle T.J. Multiple Sclerosis: oligodendrocyte proliferation and differentiation in fresh lesions. Lab. Invest. 61:1989;489-503.